A Comparative Study of Microwave-Assisted and Conventional Heating Approaches for the Multicomponent Synthesis of 4,6-Diarylpyrimidines
A series of 2-amino-4,6-diarylpyrimidines were synthesized using a Biginelli-type three-component strategy optimized in conventional-heated reflux, in contrast to a non-conventional approach using a mono-mode microwave reactor. Conventional heating protocols involved organic solvents and general...
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| Language: | English |
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Pontificia Universidad Javeriana
2023-11-01
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| Series: | Universitas Scientiarum |
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| Online Access: | https://revistas.javeriana.edu.co/index.php/scientarium/article/view/37360 |
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| author | Christian A. Becerra-Rivas Paola Andrea Cuervo Prado Fabian Orozco-Lopez |
| author_facet | Christian A. Becerra-Rivas Paola Andrea Cuervo Prado Fabian Orozco-Lopez |
| author_sort | Christian A. Becerra-Rivas |
| collection | DOAJ |
| description | A series of 2-amino-4,6-diarylpyrimidines were synthesized using a Biginelli-type three-component
strategy optimized in conventional-heated reflux, in contrast to a non-conventional approach using a
mono-mode microwave reactor. Conventional heating protocols involved organic solvents and general
base catalysis, whereas a microwave-assisted method followed experimental protocols framed within
the principles of green chemistry by using CaCl2 as a catalyst in solvent-free conditions. This study
revealed that although conventional heating led to the main product in higher yields at longer reaction
times, the microwave strategy suceeded in substantially shorter reaction times, with yields ranging
from acceptable to good and efficiencies comparable to conventional heating methodology.
|
| format | Article |
| id | doaj-art-3eec6feff23041dcba8eb826f19951ec |
| institution | OA Journals |
| issn | 0122-7483 2027-1352 |
| language | English |
| publishDate | 2023-11-01 |
| publisher | Pontificia Universidad Javeriana |
| record_format | Article |
| series | Universitas Scientiarum |
| spelling | doaj-art-3eec6feff23041dcba8eb826f19951ec2025-08-20T01:56:25ZengPontificia Universidad JaverianaUniversitas Scientiarum0122-74832027-13522023-11-0128330031510.11144/Javeriana.SC283.acsoA Comparative Study of Microwave-Assisted and Conventional Heating Approaches for the Multicomponent Synthesis of 4,6-DiarylpyrimidinesChristian A. Becerra-Rivas0https://orcid.org/0000-0002-9662-3813Paola Andrea Cuervo Prado1https://orcid.org/0000-0003-4957-2811Fabian Orozco-Lopez2https://orcid.org/0000-0003-4553-9985Universidad Nacional de Colombia, Facultad de Ciencias, Departamento de Química, Grupo de Estudios en Síntesis y Aplicaciones de Compuestos Heterocíclicos, AA 14490, Bogotá, ColombiaUniversidad Nacional de Colombia, Facultad de Ciencias, Departamento de Química, Grupo de Estudios en Síntesis y Aplicaciones de Compuestos Heterocíclicos, AA 14490, Bogotá, ColombiaUniversidad Nacional de Colombia, Facultad de Ciencias, Departamento de Química, Grupo de Estudios en Síntesis y Aplicaciones de Compuestos Heterocíclicos, AA 14490, Bogotá, ColombiaA series of 2-amino-4,6-diarylpyrimidines were synthesized using a Biginelli-type three-component strategy optimized in conventional-heated reflux, in contrast to a non-conventional approach using a mono-mode microwave reactor. Conventional heating protocols involved organic solvents and general base catalysis, whereas a microwave-assisted method followed experimental protocols framed within the principles of green chemistry by using CaCl2 as a catalyst in solvent-free conditions. This study revealed that although conventional heating led to the main product in higher yields at longer reaction times, the microwave strategy suceeded in substantially shorter reaction times, with yields ranging from acceptable to good and efficiencies comparable to conventional heating methodology. https://revistas.javeriana.edu.co/index.php/scientarium/article/view/3736046-diarylaminopyrimidines; microwave-irradiated synthesis; monomode reactor; biginelli-type reaction. |
| spellingShingle | Christian A. Becerra-Rivas Paola Andrea Cuervo Prado Fabian Orozco-Lopez A Comparative Study of Microwave-Assisted and Conventional Heating Approaches for the Multicomponent Synthesis of 4,6-Diarylpyrimidines Universitas Scientiarum 4 6-diarylaminopyrimidines; microwave-irradiated synthesis; monomode reactor; biginelli-type reaction. |
| title | A Comparative Study of Microwave-Assisted and Conventional Heating Approaches for the Multicomponent Synthesis of 4,6-Diarylpyrimidines |
| title_full | A Comparative Study of Microwave-Assisted and Conventional Heating Approaches for the Multicomponent Synthesis of 4,6-Diarylpyrimidines |
| title_fullStr | A Comparative Study of Microwave-Assisted and Conventional Heating Approaches for the Multicomponent Synthesis of 4,6-Diarylpyrimidines |
| title_full_unstemmed | A Comparative Study of Microwave-Assisted and Conventional Heating Approaches for the Multicomponent Synthesis of 4,6-Diarylpyrimidines |
| title_short | A Comparative Study of Microwave-Assisted and Conventional Heating Approaches for the Multicomponent Synthesis of 4,6-Diarylpyrimidines |
| title_sort | comparative study of microwave assisted and conventional heating approaches for the multicomponent synthesis of 4 6 diarylpyrimidines |
| topic | 4 6-diarylaminopyrimidines; microwave-irradiated synthesis; monomode reactor; biginelli-type reaction. |
| url | https://revistas.javeriana.edu.co/index.php/scientarium/article/view/37360 |
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