A Comparative Study of Microwave-Assisted and Conventional Heating Approaches for the Multicomponent Synthesis of 4,6-Diarylpyrimidines
A series of 2-amino-4,6-diarylpyrimidines were synthesized using a Biginelli-type three-component strategy optimized in conventional-heated reflux, in contrast to a non-conventional approach using a mono-mode microwave reactor. Conventional heating protocols involved organic solvents and general...
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| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
| Published: |
Pontificia Universidad Javeriana
2023-11-01
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| Series: | Universitas Scientiarum |
| Subjects: | |
| Online Access: | https://revistas.javeriana.edu.co/index.php/scientarium/article/view/37360 |
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| Summary: | A series of 2-amino-4,6-diarylpyrimidines were synthesized using a Biginelli-type three-component
strategy optimized in conventional-heated reflux, in contrast to a non-conventional approach using a
mono-mode microwave reactor. Conventional heating protocols involved organic solvents and general
base catalysis, whereas a microwave-assisted method followed experimental protocols framed within
the principles of green chemistry by using CaCl2 as a catalyst in solvent-free conditions. This study
revealed that although conventional heating led to the main product in higher yields at longer reaction
times, the microwave strategy suceeded in substantially shorter reaction times, with yields ranging
from acceptable to good and efficiencies comparable to conventional heating methodology.
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| ISSN: | 0122-7483 2027-1352 |