An mRNA lipid nanoparticle-incorporated nanofiber-hydrogel composite for cancer immunotherapy

An mRNA lipid nanoparticle-incorporated nanofiber-hydrogel composite for cancer immunotherapy

Abstract Hydrogel materials have emerged as versatile platforms for various biomedical applications. Notably, the engineered nanofiber-hydrogel composite (NHC) has proven effective in mimicking the soft tissue extracellular matrix, facilitating substantial recruitment of host immune cells and the fo...

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Main Authors: Yining Zhu, Zhi-Cheng Yao, Shuyi Li, Jingyao Ma, Christine Wei, Di Yu, Jessica L. Stelzel, Bobby Y. X. Ni, Yang Miao, Kyra Van Batavia, Xiaoya Lu, Jinghan Lin, Yifan Dai, Jiayuan Kong, Ruochen Shen, Kailei D. Goodier, Xiang Liu, Leonardo Cheng, Ivan Vuong, Gregory P. Howard, Natalie K. Livingston, Joseph Choy, Jonathan P. Schneck, Joshua C. Doloff, Sashank K. Reddy, John W. Hickey, Hai-Quan Mao
Format: Article
Language:English
Published: Nature Portfolio 2025-07-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-025-61299-8
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