Assessment of Unexpected (Non-ABO) Red Blood Cell Antibodies and Their Associated Clinical Conditions Among Patients and Blood Donors Attending University Teaching Hospital of Kigali (CHUK) and Rwanda Blood Transfusion Division

Unexpected antibodies can cause hemolytic conditions. Therefore, screening for unexpected antibodies is essential for safe transfusion. The study was conducted at Rwanda Blood Transfusion Division and University Teaching Hospital of Kigali to assess unexpected antibodies with their associated clinic...

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Main Authors: Jean Baptiste Niyibizi, Daniel Seifu, Chelsey Geurkink, Erica Formiller, Thomas Muyombo, Christopher Gashaija, Henri Desire Uwayo, Gilbert Uwizeyimana, Laurie Gillard
Format: Article
Language:English
Published: Wiley 2025-01-01
Series:Advances in Hematology
Online Access:http://dx.doi.org/10.1155/ah/8871102
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author Jean Baptiste Niyibizi
Daniel Seifu
Chelsey Geurkink
Erica Formiller
Thomas Muyombo
Christopher Gashaija
Henri Desire Uwayo
Gilbert Uwizeyimana
Laurie Gillard
author_facet Jean Baptiste Niyibizi
Daniel Seifu
Chelsey Geurkink
Erica Formiller
Thomas Muyombo
Christopher Gashaija
Henri Desire Uwayo
Gilbert Uwizeyimana
Laurie Gillard
author_sort Jean Baptiste Niyibizi
collection DOAJ
description Unexpected antibodies can cause hemolytic conditions. Therefore, screening for unexpected antibodies is essential for safe transfusion. The study was conducted at Rwanda Blood Transfusion Division and University Teaching Hospital of Kigali to assess unexpected antibodies with their associated clinical conditions. 8693 blood donors and 834 patients were screened for unexpected antibodies. Among 834 patients, 23 patients (2.75%) developed alloantibodies among which two of them had mixed alloantibodies. Five patients developed antibodies of uncertain specificities. Among 8693 blood donors, only 4 blood donors (0.046%) had clinically significant alloantibodies, whereas 6 blood donors (0.069%) had antibodies of uncertain specificities. Moreover, 3 patients (0.35%) had autoantibodies in their plasma. Different types of anemia were presented with patients who developed unexpected alloantibodies. History of transfusion and pregnancy were predictors of alloimmunization among patients (p<0.01). Antibody screening and antibody identification are important for safe blood transfusion practices.
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issn 1687-9112
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publishDate 2025-01-01
publisher Wiley
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series Advances in Hematology
spelling doaj-art-3ee7280d9b1147688a744cea2dc2acf42025-08-20T01:50:13ZengWileyAdvances in Hematology1687-91122025-01-01202510.1155/ah/8871102Assessment of Unexpected (Non-ABO) Red Blood Cell Antibodies and Their Associated Clinical Conditions Among Patients and Blood Donors Attending University Teaching Hospital of Kigali (CHUK) and Rwanda Blood Transfusion DivisionJean Baptiste Niyibizi0Daniel Seifu1Chelsey Geurkink2Erica Formiller3Thomas Muyombo4Christopher Gashaija5Henri Desire Uwayo6Gilbert Uwizeyimana7Laurie Gillard8School of MedicineSchool of MedicineCollege of Health SciencesCollege of Health SciencesBlood Transfusion Division (BTD)Blood Transfusion Division (BTD)Blood Transfusion Division (BTD)Department of PathologyCollege of Health SciencesUnexpected antibodies can cause hemolytic conditions. Therefore, screening for unexpected antibodies is essential for safe transfusion. The study was conducted at Rwanda Blood Transfusion Division and University Teaching Hospital of Kigali to assess unexpected antibodies with their associated clinical conditions. 8693 blood donors and 834 patients were screened for unexpected antibodies. Among 834 patients, 23 patients (2.75%) developed alloantibodies among which two of them had mixed alloantibodies. Five patients developed antibodies of uncertain specificities. Among 8693 blood donors, only 4 blood donors (0.046%) had clinically significant alloantibodies, whereas 6 blood donors (0.069%) had antibodies of uncertain specificities. Moreover, 3 patients (0.35%) had autoantibodies in their plasma. Different types of anemia were presented with patients who developed unexpected alloantibodies. History of transfusion and pregnancy were predictors of alloimmunization among patients (p<0.01). Antibody screening and antibody identification are important for safe blood transfusion practices.http://dx.doi.org/10.1155/ah/8871102
spellingShingle Jean Baptiste Niyibizi
Daniel Seifu
Chelsey Geurkink
Erica Formiller
Thomas Muyombo
Christopher Gashaija
Henri Desire Uwayo
Gilbert Uwizeyimana
Laurie Gillard
Assessment of Unexpected (Non-ABO) Red Blood Cell Antibodies and Their Associated Clinical Conditions Among Patients and Blood Donors Attending University Teaching Hospital of Kigali (CHUK) and Rwanda Blood Transfusion Division
Advances in Hematology
title Assessment of Unexpected (Non-ABO) Red Blood Cell Antibodies and Their Associated Clinical Conditions Among Patients and Blood Donors Attending University Teaching Hospital of Kigali (CHUK) and Rwanda Blood Transfusion Division
title_full Assessment of Unexpected (Non-ABO) Red Blood Cell Antibodies and Their Associated Clinical Conditions Among Patients and Blood Donors Attending University Teaching Hospital of Kigali (CHUK) and Rwanda Blood Transfusion Division
title_fullStr Assessment of Unexpected (Non-ABO) Red Blood Cell Antibodies and Their Associated Clinical Conditions Among Patients and Blood Donors Attending University Teaching Hospital of Kigali (CHUK) and Rwanda Blood Transfusion Division
title_full_unstemmed Assessment of Unexpected (Non-ABO) Red Blood Cell Antibodies and Their Associated Clinical Conditions Among Patients and Blood Donors Attending University Teaching Hospital of Kigali (CHUK) and Rwanda Blood Transfusion Division
title_short Assessment of Unexpected (Non-ABO) Red Blood Cell Antibodies and Their Associated Clinical Conditions Among Patients and Blood Donors Attending University Teaching Hospital of Kigali (CHUK) and Rwanda Blood Transfusion Division
title_sort assessment of unexpected non abo red blood cell antibodies and their associated clinical conditions among patients and blood donors attending university teaching hospital of kigali chuk and rwanda blood transfusion division
url http://dx.doi.org/10.1155/ah/8871102
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