PAX8 Distinguishes Diffuse Large B-Cell Lymphoma Mimicking Sarcoma
PAX8 is important for embryogenesis of the thyroid, Müllerian system, and upper urinary/renal tract, and expression of PAX8 has been described in carcinomas from each of these sites. The sensitivity and specificity of the polyclonal PAX8 antibody in a large cohort of epithelial tumors as well as lym...
Saved in:
| Main Authors: | , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2017-01-01
|
| Series: | Case Reports in Pathology |
| Online Access: | http://dx.doi.org/10.1155/2017/6714549 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832551456756989952 |
|---|---|
| author | Michelle S. Hirsch Alessandra F. Nascimento |
| author_facet | Michelle S. Hirsch Alessandra F. Nascimento |
| author_sort | Michelle S. Hirsch |
| collection | DOAJ |
| description | PAX8 is important for embryogenesis of the thyroid, Müllerian system, and upper urinary/renal tract, and expression of PAX8 has been described in carcinomas from each of these sites. The sensitivity and specificity of the polyclonal PAX8 antibody in a large cohort of epithelial tumors as well as lymphomas have been previously determined, the latter because polyclonal PAX8 is known to be immunoreactive in nonneoplastic B-cell lymphocytes which are often used as the positive internal control for immunohistochemistry. In this case report, PAX8 was a diagnostic clue for revising a previous diagnosis of unclassified high grade sarcoma to diffuse large B-cell lymphoma. This case report demonstrates a pitfall for PAX8 immunoreactivity and acts as a reminder that lymphoma should be included in the differential diagnosis of a PAX8 positive, epithelial cell marker negative tumor of unknown primary origin. |
| format | Article |
| id | doaj-art-3ee614ce3a84440083b0e264adb60aad |
| institution | Kabale University |
| issn | 2090-6781 2090-679X |
| language | English |
| publishDate | 2017-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Case Reports in Pathology |
| spelling | doaj-art-3ee614ce3a84440083b0e264adb60aad2025-02-03T06:01:28ZengWileyCase Reports in Pathology2090-67812090-679X2017-01-01201710.1155/2017/67145496714549PAX8 Distinguishes Diffuse Large B-Cell Lymphoma Mimicking SarcomaMichelle S. Hirsch0Alessandra F. Nascimento1Department of Pathology, Brigham and Women’s Hospital and Harvard Medical School, Boston, MA, USADiagnose Anatomia Patologica e Citopatologia, Rio de Janeiro, RJ, BrazilPAX8 is important for embryogenesis of the thyroid, Müllerian system, and upper urinary/renal tract, and expression of PAX8 has been described in carcinomas from each of these sites. The sensitivity and specificity of the polyclonal PAX8 antibody in a large cohort of epithelial tumors as well as lymphomas have been previously determined, the latter because polyclonal PAX8 is known to be immunoreactive in nonneoplastic B-cell lymphocytes which are often used as the positive internal control for immunohistochemistry. In this case report, PAX8 was a diagnostic clue for revising a previous diagnosis of unclassified high grade sarcoma to diffuse large B-cell lymphoma. This case report demonstrates a pitfall for PAX8 immunoreactivity and acts as a reminder that lymphoma should be included in the differential diagnosis of a PAX8 positive, epithelial cell marker negative tumor of unknown primary origin.http://dx.doi.org/10.1155/2017/6714549 |
| spellingShingle | Michelle S. Hirsch Alessandra F. Nascimento PAX8 Distinguishes Diffuse Large B-Cell Lymphoma Mimicking Sarcoma Case Reports in Pathology |
| title | PAX8 Distinguishes Diffuse Large B-Cell Lymphoma Mimicking Sarcoma |
| title_full | PAX8 Distinguishes Diffuse Large B-Cell Lymphoma Mimicking Sarcoma |
| title_fullStr | PAX8 Distinguishes Diffuse Large B-Cell Lymphoma Mimicking Sarcoma |
| title_full_unstemmed | PAX8 Distinguishes Diffuse Large B-Cell Lymphoma Mimicking Sarcoma |
| title_short | PAX8 Distinguishes Diffuse Large B-Cell Lymphoma Mimicking Sarcoma |
| title_sort | pax8 distinguishes diffuse large b cell lymphoma mimicking sarcoma |
| url | http://dx.doi.org/10.1155/2017/6714549 |
| work_keys_str_mv | AT michelleshirsch pax8distinguishesdiffuselargebcelllymphomamimickingsarcoma AT alessandrafnascimento pax8distinguishesdiffuselargebcelllymphomamimickingsarcoma |