Nonlinear Association Between the Liver Fat Content and the Risk of Hyperuricemia in Prediabetic Individuals: Evidence from Cross-Sectional Health Screening Data in China
Ao Liu,1 Xin Li,2 Xueyi Zhang,1 Keke Chen,3 Zhi Zou,4 Yongbing Sun,1 Jing Zhou,5 Zhonglin Li,4 Xiaoling Wu,6 Xue Lv,5 Hao Li,7 Zhiping Guo,8 Yongli Li5 1Department of Medical Imaging, People’s Hospital of Zhengzhou University, Zhengzhou, 450003, People’s Republic of China; 2Department of Medical Ima...
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Dove Medical Press
2025-02-01
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| Series: | Diabetes, Metabolic Syndrome and Obesity |
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| author | Liu A Li X Zhang X Chen K Zou Z Sun Y Zhou J Li Z Wu X Lv X Li H Guo Z Li Y |
| author_facet | Liu A Li X Zhang X Chen K Zou Z Sun Y Zhou J Li Z Wu X Lv X Li H Guo Z Li Y |
| author_sort | Liu A |
| collection | DOAJ |
| description | Ao Liu,1 Xin Li,2 Xueyi Zhang,1 Keke Chen,3 Zhi Zou,4 Yongbing Sun,1 Jing Zhou,5 Zhonglin Li,4 Xiaoling Wu,6 Xue Lv,5 Hao Li,7 Zhiping Guo,8 Yongli Li5 1Department of Medical Imaging, People’s Hospital of Zhengzhou University, Zhengzhou, 450003, People’s Republic of China; 2Department of Medical Imaging, People’s Hospital of Henan University, Zhengzhou, 450003, People’s Republic of China; 3Department of Medical Imaging, Henan Provincial People’s Hospital, Xinxiang Medical College, Zhengzhou, 450003, People’s Republic of China; 4Department of Medical Imaging, Henan Provincial People’s Hospital, Zhengzhou, 450003, People’s Republic of China; 5Department of Health Management, Henan Provincial Key Laboratory of Chronic Disease Health Management, Henan Provincial People’s Hospital, Zhengzhou, 450003, People’s Republic of China; 6Department of Nuclear Medicine, Henan Provincial People’s Hospital, Zhengzhou, 450003, People’s Republic of China; 7Department of Health Management, Fuwai Central China Cardiovascular Hospital, Zhengzhou, 451464, People’s Republic of China; 8Henan Provincial Key Laboratory of Chronic Disease Health Management, Fuwai Huazhong Cardiovascular Hospital, Zhengzhou, 450003, People’s Republic of ChinaCorrespondence: Yongli Li, Department of Health Management, Henan Provincial Key Laboratory of Chronic Disease Health Management, Henan Provincial People’s Hospital, Zhengzhou, 450003, People’s Republic of China, Email shyliyongli@126.comPurpose: The impact of hepatic lipid accumulation on hyperuricemia presents an intriguing research avenue, particularly in light of existing studies linking obesity with hyperuricemia. Nevertheless, there remains a scarcity of quantitative investigations into the correlation between liver fat content (LFC) and hyperuricemia among prediabetic cohorts, notably within the Chinese demographic.Patients and Methods: This cross-sectional study was conducted at the Health Management Center of Henan Provincial People’s Hospital between January 2019 and December 2023, involving 2,950 pre-diabetic participants. Participants were categorized into groups based on diagnostic criteria for hyperuricemia. LFC was assessed using computed tomography. Statistical analyses included multivariate logistic regression, limited cubic spline regression models, and subgroup analyses to explore the association between LFC and hyperuricemia among individuals with pre-diabetes.Results: The prevalence of hyperuricemia among the 2,950 prediabetic individuals was observed to be 22.20%. Prediabetic individuals with hyperuricemia exhibited higher levels of LFC compared to those without hyperuricemia. This association persisted even after adjusting for other variables, indicating a heightened risk of hyperuricemia among prediabetic individuals with elevated LFC [Q4 vs Q1: odds ratio (OR 2.70), 95% confidence interval (CI) 1.93– 3.79, P < 0.001; P for trend < 0.001]. Importantly, a nonlinear relationship between LFC and hyperuricemia risk was identified in the prediabetic individuals, showing a significant increase in hyperuricemia risk when LFC exceeded 8.4% (OR per standard deviation = 1.05, 95% CI: 1.02– 1.08, P < 0.001).Conclusion: In individuals with prediabetes, a higher LFC is associated with an elevated risk of hyperuricemia, especially when LFC exceeds 8.4%.Keywords: hyperuricemia, LFC, prediabetes, Chinese adults |
| format | Article |
| id | doaj-art-3edd948024dd4a32934c33f3abf77cc2 |
| institution | Kabale University |
| issn | 1178-7007 |
| language | English |
| publishDate | 2025-02-01 |
| publisher | Dove Medical Press |
| record_format | Article |
| series | Diabetes, Metabolic Syndrome and Obesity |
| spelling | doaj-art-3edd948024dd4a32934c33f3abf77cc22025-02-11T17:30:55ZengDove Medical PressDiabetes, Metabolic Syndrome and Obesity1178-70072025-02-01Volume 18423434100107Nonlinear Association Between the Liver Fat Content and the Risk of Hyperuricemia in Prediabetic Individuals: Evidence from Cross-Sectional Health Screening Data in ChinaLiu ALi XZhang XChen KZou ZSun YZhou JLi ZWu XLv XLi HGuo ZLi YAo Liu,1 Xin Li,2 Xueyi Zhang,1 Keke Chen,3 Zhi Zou,4 Yongbing Sun,1 Jing Zhou,5 Zhonglin Li,4 Xiaoling Wu,6 Xue Lv,5 Hao Li,7 Zhiping Guo,8 Yongli Li5 1Department of Medical Imaging, People’s Hospital of Zhengzhou University, Zhengzhou, 450003, People’s Republic of China; 2Department of Medical Imaging, People’s Hospital of Henan University, Zhengzhou, 450003, People’s Republic of China; 3Department of Medical Imaging, Henan Provincial People’s Hospital, Xinxiang Medical College, Zhengzhou, 450003, People’s Republic of China; 4Department of Medical Imaging, Henan Provincial People’s Hospital, Zhengzhou, 450003, People’s Republic of China; 5Department of Health Management, Henan Provincial Key Laboratory of Chronic Disease Health Management, Henan Provincial People’s Hospital, Zhengzhou, 450003, People’s Republic of China; 6Department of Nuclear Medicine, Henan Provincial People’s Hospital, Zhengzhou, 450003, People’s Republic of China; 7Department of Health Management, Fuwai Central China Cardiovascular Hospital, Zhengzhou, 451464, People’s Republic of China; 8Henan Provincial Key Laboratory of Chronic Disease Health Management, Fuwai Huazhong Cardiovascular Hospital, Zhengzhou, 450003, People’s Republic of ChinaCorrespondence: Yongli Li, Department of Health Management, Henan Provincial Key Laboratory of Chronic Disease Health Management, Henan Provincial People’s Hospital, Zhengzhou, 450003, People’s Republic of China, Email shyliyongli@126.comPurpose: The impact of hepatic lipid accumulation on hyperuricemia presents an intriguing research avenue, particularly in light of existing studies linking obesity with hyperuricemia. Nevertheless, there remains a scarcity of quantitative investigations into the correlation between liver fat content (LFC) and hyperuricemia among prediabetic cohorts, notably within the Chinese demographic.Patients and Methods: This cross-sectional study was conducted at the Health Management Center of Henan Provincial People’s Hospital between January 2019 and December 2023, involving 2,950 pre-diabetic participants. Participants were categorized into groups based on diagnostic criteria for hyperuricemia. LFC was assessed using computed tomography. Statistical analyses included multivariate logistic regression, limited cubic spline regression models, and subgroup analyses to explore the association between LFC and hyperuricemia among individuals with pre-diabetes.Results: The prevalence of hyperuricemia among the 2,950 prediabetic individuals was observed to be 22.20%. Prediabetic individuals with hyperuricemia exhibited higher levels of LFC compared to those without hyperuricemia. This association persisted even after adjusting for other variables, indicating a heightened risk of hyperuricemia among prediabetic individuals with elevated LFC [Q4 vs Q1: odds ratio (OR 2.70), 95% confidence interval (CI) 1.93– 3.79, P < 0.001; P for trend < 0.001]. Importantly, a nonlinear relationship between LFC and hyperuricemia risk was identified in the prediabetic individuals, showing a significant increase in hyperuricemia risk when LFC exceeded 8.4% (OR per standard deviation = 1.05, 95% CI: 1.02– 1.08, P < 0.001).Conclusion: In individuals with prediabetes, a higher LFC is associated with an elevated risk of hyperuricemia, especially when LFC exceeds 8.4%.Keywords: hyperuricemia, LFC, prediabetes, Chinese adultshttps://www.dovepress.com/nonlinear-association-between-the-liver-fat-content-and-the-risk-of-hy-peer-reviewed-fulltext-article-DMSOhyperuricemialfcprediabeteschinese adults |
| spellingShingle | Liu A Li X Zhang X Chen K Zou Z Sun Y Zhou J Li Z Wu X Lv X Li H Guo Z Li Y Nonlinear Association Between the Liver Fat Content and the Risk of Hyperuricemia in Prediabetic Individuals: Evidence from Cross-Sectional Health Screening Data in China Diabetes, Metabolic Syndrome and Obesity hyperuricemia lfc prediabetes chinese adults |
| title | Nonlinear Association Between the Liver Fat Content and the Risk of Hyperuricemia in Prediabetic Individuals: Evidence from Cross-Sectional Health Screening Data in China |
| title_full | Nonlinear Association Between the Liver Fat Content and the Risk of Hyperuricemia in Prediabetic Individuals: Evidence from Cross-Sectional Health Screening Data in China |
| title_fullStr | Nonlinear Association Between the Liver Fat Content and the Risk of Hyperuricemia in Prediabetic Individuals: Evidence from Cross-Sectional Health Screening Data in China |
| title_full_unstemmed | Nonlinear Association Between the Liver Fat Content and the Risk of Hyperuricemia in Prediabetic Individuals: Evidence from Cross-Sectional Health Screening Data in China |
| title_short | Nonlinear Association Between the Liver Fat Content and the Risk of Hyperuricemia in Prediabetic Individuals: Evidence from Cross-Sectional Health Screening Data in China |
| title_sort | nonlinear association between the liver fat content and the risk of hyperuricemia in prediabetic individuals evidence from cross sectional health screening data in china |
| topic | hyperuricemia lfc prediabetes chinese adults |
| url | https://www.dovepress.com/nonlinear-association-between-the-liver-fat-content-and-the-risk-of-hy-peer-reviewed-fulltext-article-DMSO |
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