High-fat diet and neuroinflammation: The role of mitochondria
In recent years, increasing evidence has supported that high-fat diet (HFD) can induce the chronic, low-grade neuroinflammation in the brain, which is closely associated with the impairment of cognitive function. As the key organelles responsible for energy metabolism in the cell, mitochondria are b...
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| Language: | English |
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Elsevier
2025-02-01
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| Series: | Pharmacological Research |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S1043661825000404 |
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| author | Mingxue Song Yao Bai Fuyong Song |
| author_facet | Mingxue Song Yao Bai Fuyong Song |
| author_sort | Mingxue Song |
| collection | DOAJ |
| description | In recent years, increasing evidence has supported that high-fat diet (HFD) can induce the chronic, low-grade neuroinflammation in the brain, which is closely associated with the impairment of cognitive function. As the key organelles responsible for energy metabolism in the cell, mitochondria are believed to involved in the pathogenesis of a variety of neurological disorders. This review summarizes the current progress in the field of the relationship between HFD exposure and neurodegenerative diseases, and outline the major routines of HFD induced neuroinflammation and its pathological significance in the pathogenesis of neurodegenerative diseases. Furthermore, the article highlights the pivotal role of mitochondrial dysfunction in driving the neuroinflammation in the setting of HFD. Danger-associated molecular patterns (DAMPs) from damaged mitochondria can activate innate immune signaling pathways, while mitochondrial dysfunction itself can lead to metabolic remodeling of inflammatory cells, thus inducing neuroinflammation. More importantly, mitochondrial damage, neuroinflammation, and insulin resistance caused by HFD form a mutually reinforcing vicious cycle, ultimately leading to the death of neurons and promoting the progression of neurodegenerative diseases. Thus, in-depth elucidation of the role and underlying mechanisms of mitochondrial dysfunction in HFD-induced metabolic disorders may not only expand our understanding of the mechanistic linkages between HFD and etiology of neurodegenerative diseases, but also help develop the specific strategies for the prevention and treatment of neurodegenerative diseases. |
| format | Article |
| id | doaj-art-3edb28d32fef485ab95eb28b2d2617c1 |
| institution | Kabale University |
| issn | 1096-1186 |
| language | English |
| publishDate | 2025-02-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Pharmacological Research |
| spelling | doaj-art-3edb28d32fef485ab95eb28b2d2617c12025-02-08T04:59:52ZengElsevierPharmacological Research1096-11862025-02-01212107615High-fat diet and neuroinflammation: The role of mitochondriaMingxue Song0Yao Bai1Fuyong Song2Department of Toxicology, School of Public Health, Cheeloo College of Medicine, Shandong University, 44 Wenhuaxi Road, Jinan, Shandong 250012, ChinaNHC Key Laboratory of Food Safety Risk Assessment, China National Center for Food Safety Risk Assessment, Beijing 100021, China; Corresponding authors.Department of Toxicology, School of Public Health, Cheeloo College of Medicine, Shandong University, 44 Wenhuaxi Road, Jinan, Shandong 250012, China; Corresponding authors.In recent years, increasing evidence has supported that high-fat diet (HFD) can induce the chronic, low-grade neuroinflammation in the brain, which is closely associated with the impairment of cognitive function. As the key organelles responsible for energy metabolism in the cell, mitochondria are believed to involved in the pathogenesis of a variety of neurological disorders. This review summarizes the current progress in the field of the relationship between HFD exposure and neurodegenerative diseases, and outline the major routines of HFD induced neuroinflammation and its pathological significance in the pathogenesis of neurodegenerative diseases. Furthermore, the article highlights the pivotal role of mitochondrial dysfunction in driving the neuroinflammation in the setting of HFD. Danger-associated molecular patterns (DAMPs) from damaged mitochondria can activate innate immune signaling pathways, while mitochondrial dysfunction itself can lead to metabolic remodeling of inflammatory cells, thus inducing neuroinflammation. More importantly, mitochondrial damage, neuroinflammation, and insulin resistance caused by HFD form a mutually reinforcing vicious cycle, ultimately leading to the death of neurons and promoting the progression of neurodegenerative diseases. Thus, in-depth elucidation of the role and underlying mechanisms of mitochondrial dysfunction in HFD-induced metabolic disorders may not only expand our understanding of the mechanistic linkages between HFD and etiology of neurodegenerative diseases, but also help develop the specific strategies for the prevention and treatment of neurodegenerative diseases.http://www.sciencedirect.com/science/article/pii/S1043661825000404High-fat diet (HFD)mitochondrial dysfunctionneuroinflammationneurodegenerative diseasesobesityoxidative stress |
| spellingShingle | Mingxue Song Yao Bai Fuyong Song High-fat diet and neuroinflammation: The role of mitochondria Pharmacological Research High-fat diet (HFD) mitochondrial dysfunction neuroinflammation neurodegenerative diseases obesity oxidative stress |
| title | High-fat diet and neuroinflammation: The role of mitochondria |
| title_full | High-fat diet and neuroinflammation: The role of mitochondria |
| title_fullStr | High-fat diet and neuroinflammation: The role of mitochondria |
| title_full_unstemmed | High-fat diet and neuroinflammation: The role of mitochondria |
| title_short | High-fat diet and neuroinflammation: The role of mitochondria |
| title_sort | high fat diet and neuroinflammation the role of mitochondria |
| topic | High-fat diet (HFD) mitochondrial dysfunction neuroinflammation neurodegenerative diseases obesity oxidative stress |
| url | http://www.sciencedirect.com/science/article/pii/S1043661825000404 |
| work_keys_str_mv | AT mingxuesong highfatdietandneuroinflammationtheroleofmitochondria AT yaobai highfatdietandneuroinflammationtheroleofmitochondria AT fuyongsong highfatdietandneuroinflammationtheroleofmitochondria |