Impact of administration route and gene polymorphisms on the serum concentration of voriconazole among Chinese patients with hematologic malignancies

Impact of administration route and gene polymorphisms on the serum concentration of voriconazole among Chinese patients with hematologic malignancies

AimsVoriconazole (VRC) is recommended as the first-line treatment for invasive fungal diseases (IFDs). Therapeutic drug monitoring (TDM)-based dose adjustments can be performed to implement the individualized use of VRC in clinical practice. Numerous studies have shown significant interindividual di...

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Bibliographic Details
Main Authors: Zhiyao Chen, Menghua Zhang, Lin Wang, Yuzhu Cheng, Liyan Miao
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-07-01
Series:Frontiers in Pharmacology
Subjects:
voriconazole
serum concentration
hematologic malignancies
gene polymorphisms
CYP3A4
CYP2C19
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2025.1445583/full
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