Kininogen enhances seizure susceptibility in mice possibly through bradykinin-induced modulation of calcium transients in glutamatergic and GABAergic neurons

Kininogen enhances seizure susceptibility in mice possibly through bradykinin-induced modulation of calcium transients in glutamatergic and GABAergic neurons

BackgroundPreviously we showed that elevated cerebrospinal fluid (CSF) levels of kininogen during the acute phase of encephalitis are associated with symptomatic epilepsy. However, the functional role of kininogen in epileptogenesis remains unexplored.ObjectiveThis study investigated the brain expre...

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Bibliographic Details
Main Authors: Arijit Ghosh, Jiwen Huang, Qian Wang, Yanling Gong, Srishti Jain, Abhimanyu Thakur, Amiyangshu De, Meixi Gong, Yoshie Kiyohara, Jingtai Hu, Lingyan Jin, Sharba Bandyopadhyay, Fang Chen, Shengtian Li
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-06-01
Series:Frontiers in Pharmacology
Subjects:
calcium imaging
parvalbumin
pentylenetetrazole
pilocarpine
PVCre-GCaMP6f, seizure imaging, Thy1-GCaMP6f
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2025.1509837/full
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