Male Breast Cancer Complicated With Leukocytosis Resembling Leukemia Reaction After Chemotherapy: A Case Report
ABSTRACT Introduction Male breast cancer (MBC) accounts for less than 1% of all cancers in men, with invasive ductal carcinoma being the most common type. The chemotherapy regimens used for MBC are similar to those for female breast cancer. However, the incidence of chemotherapy‐induced complication...
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Wiley
2025-07-01
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| Online Access: | https://doi.org/10.1002/cnr2.70280 |
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| author | Yanze Liu Jiaqi Liu |
| author_facet | Yanze Liu Jiaqi Liu |
| author_sort | Yanze Liu |
| collection | DOAJ |
| description | ABSTRACT Introduction Male breast cancer (MBC) accounts for less than 1% of all cancers in men, with invasive ductal carcinoma being the most common type. The chemotherapy regimens used for MBC are similar to those for female breast cancer. However, the incidence of chemotherapy‐induced complications such as leukocytosis resembling leukemia reaction is not well documented in MBC. This case highlights a rare complication in an MBC patient, induced by prophylactic PEG‐rhG‐CSF following chemotherapy. Case Presentation A 51‐year‐old male with left breast invasive ductal carcinoma underwent modified radical mastectomy. Postoperative pathology revealed high‐risk features, and the patient received 8 cycles of chemotherapy with the ddAC‐T regimen, followed by PEG‐rhG‐CSF for febrile neutropenia prevention. After the fifth chemotherapy cycle, the patient developed leukocytosis resembling leukemia reaction, characterized by a white blood cell count exceeding 50 × 109/L, along with intermittent fever up to 42.5°C. The condition was attributed to the PEG‐rhG‐CSF administration, and the patient was treated with NSAIDs and dexamethasone. Leukocytosis resolved after adjusting the PEG‐rhG‐CSF dose. Conclusion Leukocytosis resembling leukemia reaction induced by PEG‐rhG‐CSF post‐chemotherapy is a rare complication, particularly in MBC patients. This case underscores the importance of careful monitoring and differential diagnosis to avoid misdiagnosis and unnecessary interventions. Personalized treatment strategies and dose adjustments for PEG‐rhG‐CSF are crucial in managing this rare reaction, emphasizing the need for awareness and individualized care in MBC patients undergoing chemotherapy. |
| format | Article |
| id | doaj-art-3ed30b1284f34b2eba17c7f44f5dd32b |
| institution | Kabale University |
| issn | 2573-8348 |
| language | English |
| publishDate | 2025-07-01 |
| publisher | Wiley |
| record_format | Article |
| series | Cancer Reports |
| spelling | doaj-art-3ed30b1284f34b2eba17c7f44f5dd32b2025-08-20T03:34:28ZengWileyCancer Reports2573-83482025-07-0187n/an/a10.1002/cnr2.70280Male Breast Cancer Complicated With Leukocytosis Resembling Leukemia Reaction After Chemotherapy: A Case ReportYanze Liu0Jiaqi Liu1Department of Breast and Thyroid Surgery Zibo Central Hospital Zibo Shandong ChinaDepartment of Breast and Thyroid Surgery Zibo Central Hospital Zibo Shandong ChinaABSTRACT Introduction Male breast cancer (MBC) accounts for less than 1% of all cancers in men, with invasive ductal carcinoma being the most common type. The chemotherapy regimens used for MBC are similar to those for female breast cancer. However, the incidence of chemotherapy‐induced complications such as leukocytosis resembling leukemia reaction is not well documented in MBC. This case highlights a rare complication in an MBC patient, induced by prophylactic PEG‐rhG‐CSF following chemotherapy. Case Presentation A 51‐year‐old male with left breast invasive ductal carcinoma underwent modified radical mastectomy. Postoperative pathology revealed high‐risk features, and the patient received 8 cycles of chemotherapy with the ddAC‐T regimen, followed by PEG‐rhG‐CSF for febrile neutropenia prevention. After the fifth chemotherapy cycle, the patient developed leukocytosis resembling leukemia reaction, characterized by a white blood cell count exceeding 50 × 109/L, along with intermittent fever up to 42.5°C. The condition was attributed to the PEG‐rhG‐CSF administration, and the patient was treated with NSAIDs and dexamethasone. Leukocytosis resolved after adjusting the PEG‐rhG‐CSF dose. Conclusion Leukocytosis resembling leukemia reaction induced by PEG‐rhG‐CSF post‐chemotherapy is a rare complication, particularly in MBC patients. This case underscores the importance of careful monitoring and differential diagnosis to avoid misdiagnosis and unnecessary interventions. Personalized treatment strategies and dose adjustments for PEG‐rhG‐CSF are crucial in managing this rare reaction, emphasizing the need for awareness and individualized care in MBC patients undergoing chemotherapy.https://doi.org/10.1002/cnr2.70280chemotherapyleukocytosis resembling leukemia reactionmale breast cancer |
| spellingShingle | Yanze Liu Jiaqi Liu Male Breast Cancer Complicated With Leukocytosis Resembling Leukemia Reaction After Chemotherapy: A Case Report Cancer Reports chemotherapy leukocytosis resembling leukemia reaction male breast cancer |
| title | Male Breast Cancer Complicated With Leukocytosis Resembling Leukemia Reaction After Chemotherapy: A Case Report |
| title_full | Male Breast Cancer Complicated With Leukocytosis Resembling Leukemia Reaction After Chemotherapy: A Case Report |
| title_fullStr | Male Breast Cancer Complicated With Leukocytosis Resembling Leukemia Reaction After Chemotherapy: A Case Report |
| title_full_unstemmed | Male Breast Cancer Complicated With Leukocytosis Resembling Leukemia Reaction After Chemotherapy: A Case Report |
| title_short | Male Breast Cancer Complicated With Leukocytosis Resembling Leukemia Reaction After Chemotherapy: A Case Report |
| title_sort | male breast cancer complicated with leukocytosis resembling leukemia reaction after chemotherapy a case report |
| topic | chemotherapy leukocytosis resembling leukemia reaction male breast cancer |
| url | https://doi.org/10.1002/cnr2.70280 |
| work_keys_str_mv | AT yanzeliu malebreastcancercomplicatedwithleukocytosisresemblingleukemiareactionafterchemotherapyacasereport AT jiaqiliu malebreastcancercomplicatedwithleukocytosisresemblingleukemiareactionafterchemotherapyacasereport |