Antiviral and Virucidal Activities of N𝜶-Cocoyl-L-Arginine Ethyl Ester
Various amino acid-derived compounds, for example, Nα-Cocoyl-L-arginine ethyl ester (CAE), alkyloxyhydroxylpropylarginine, arginine cocoate, and cocoyl glycine potassium salt (Amilite), were examined for their virucidal activities against herpes simplex virus type 1 and 2 (HSV-1 and HSV-2), influenz...
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| Format: | Article |
| Language: | English |
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Wiley
2011-01-01
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| Series: | Advances in Virology |
| Online Access: | http://dx.doi.org/10.1155/2011/572868 |
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| author | Hisashi Yamasaki Kazuko Tsujimoto Keiko Ikeda Yukiko Suzuki Tsutomu Arakawa A. Hajime Koyama |
| author_facet | Hisashi Yamasaki Kazuko Tsujimoto Keiko Ikeda Yukiko Suzuki Tsutomu Arakawa A. Hajime Koyama |
| author_sort | Hisashi Yamasaki |
| collection | DOAJ |
| description | Various amino acid-derived compounds, for example, Nα-Cocoyl-L-arginine ethyl ester (CAE), alkyloxyhydroxylpropylarginine, arginine cocoate, and cocoyl glycine potassium salt (Amilite), were examined for their virucidal activities against herpes simplex virus type 1 and 2 (HSV-1 and HSV-2), influenza A virus (IAV), and poliovirus type 1 (PV-1) in comparison to benzalkonium chloride (BKC) and sodium dodecylsulfate (SDS) as a cationic and anionic control detergent and also to other commercially available disinfectants. While these amino acid-derived compounds were all effective against HSV-1 and HSV-2, CAE and Amilite were the most effective. These two compounds were, however, not as effective against IAV, another enveloped virus, as against HSV. Cytotoxicity of CAE was weak; at 0.012%, only 5% of the cells were killed under the conditions, in which 100% cells were killed by either SDS or BKC. In addition to these direct virucidal effects, CAE inhibited the virus growth in the HSV-1- or PV-1-infected cells even at 0.01%. These results suggest a potential application of CAE as a therapeutic or preventive medicine against HSV superficial infection at body surface. |
| format | Article |
| id | doaj-art-3ecec7f0d82e426ab1d2cc1b3b4ce90f |
| institution | Kabale University |
| issn | 1687-8639 1687-8647 |
| language | English |
| publishDate | 2011-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Advances in Virology |
| spelling | doaj-art-3ecec7f0d82e426ab1d2cc1b3b4ce90f2025-08-20T03:35:53ZengWileyAdvances in Virology1687-86391687-86472011-01-01201110.1155/2011/572868572868Antiviral and Virucidal Activities of N𝜶-Cocoyl-L-Arginine Ethyl EsterHisashi Yamasaki0Kazuko Tsujimoto1Keiko Ikeda2Yukiko Suzuki3Tsutomu Arakawa4A. Hajime Koyama5Division of Virology, Department of Cellular and Molecular Medicine, Graduate School of Medicine, Wakayama Medical University, 580 Mikazura, Wakayama 641-0011, JapanDivision of Virology, Department of Cellular and Molecular Medicine, Graduate School of Medicine, Wakayama Medical University, 580 Mikazura, Wakayama 641-0011, JapanDivision of Virology, Department of Cellular and Molecular Medicine, Graduate School of Medicine, Wakayama Medical University, 580 Mikazura, Wakayama 641-0011, JapanSchool of Health and Nursing Science, Wakayama Medical University, 580 Mikazura, Wakayama 641-0011, JapanAlliance Protein Laboratories, Thousand Oaks, CA 91360, USADivision of Virology, Department of Cellular and Molecular Medicine, Graduate School of Medicine, Wakayama Medical University, 580 Mikazura, Wakayama 641-0011, JapanVarious amino acid-derived compounds, for example, Nα-Cocoyl-L-arginine ethyl ester (CAE), alkyloxyhydroxylpropylarginine, arginine cocoate, and cocoyl glycine potassium salt (Amilite), were examined for their virucidal activities against herpes simplex virus type 1 and 2 (HSV-1 and HSV-2), influenza A virus (IAV), and poliovirus type 1 (PV-1) in comparison to benzalkonium chloride (BKC) and sodium dodecylsulfate (SDS) as a cationic and anionic control detergent and also to other commercially available disinfectants. While these amino acid-derived compounds were all effective against HSV-1 and HSV-2, CAE and Amilite were the most effective. These two compounds were, however, not as effective against IAV, another enveloped virus, as against HSV. Cytotoxicity of CAE was weak; at 0.012%, only 5% of the cells were killed under the conditions, in which 100% cells were killed by either SDS or BKC. In addition to these direct virucidal effects, CAE inhibited the virus growth in the HSV-1- or PV-1-infected cells even at 0.01%. These results suggest a potential application of CAE as a therapeutic or preventive medicine against HSV superficial infection at body surface.http://dx.doi.org/10.1155/2011/572868 |
| spellingShingle | Hisashi Yamasaki Kazuko Tsujimoto Keiko Ikeda Yukiko Suzuki Tsutomu Arakawa A. Hajime Koyama Antiviral and Virucidal Activities of N𝜶-Cocoyl-L-Arginine Ethyl Ester Advances in Virology |
| title | Antiviral and Virucidal Activities of N𝜶-Cocoyl-L-Arginine Ethyl Ester |
| title_full | Antiviral and Virucidal Activities of N𝜶-Cocoyl-L-Arginine Ethyl Ester |
| title_fullStr | Antiviral and Virucidal Activities of N𝜶-Cocoyl-L-Arginine Ethyl Ester |
| title_full_unstemmed | Antiviral and Virucidal Activities of N𝜶-Cocoyl-L-Arginine Ethyl Ester |
| title_short | Antiviral and Virucidal Activities of N𝜶-Cocoyl-L-Arginine Ethyl Ester |
| title_sort | antiviral and virucidal activities of n𝜶 cocoyl l arginine ethyl ester |
| url | http://dx.doi.org/10.1155/2011/572868 |
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