EVALUATION THE EFFECT OF METFORMIN ON HORMONES SERUM LEVELS IN WOMEN WITH POLYCYSTIC OVARY SYNDROME
Background: Polycystic ovary syndrome [PCOS] is a common disease that affected the reproductive problem. Aim: the study tried to determine the association between PCOS with the body mass index (BMI) and the effect of metformin as treatment for PCOS. Patients and Methods: This case control prospe...
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Tikrit University
2023-02-01
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| Series: | Tikrit Journal of Pure Science |
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| Online Access: | https://tjpsj.org/index.php/tjps/article/view/865 |
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| author | Liqaa S. Baqer Mutaz S. Ahmeid Amena H. Al-Obaidi |
| author_facet | Liqaa S. Baqer Mutaz S. Ahmeid Amena H. Al-Obaidi |
| author_sort | Liqaa S. Baqer |
| collection | DOAJ |
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Background: Polycystic ovary syndrome [PCOS] is a common disease that affected the reproductive problem. Aim: the study tried to determine the association between PCOS with the body mass index (BMI) and the effect of metformin as treatment for PCOS.
Patients and Methods: This case control prospective experimental study was carried out in Kirkuk General Hospital from January 2014 to July 2014. The recruited cases divided into three groups; Group I, 68 women with normal menstrual cycle as control group; Group II, 61 cases diagnosed as a PCOS; and Group III :- 30 cases selected from group two to receive treatment with Metformin to determine the effect of the treatment on different variables. Results: The highest percentage of PCOS (36.1%) was found in those with age group between (20-25) years. Most (65.6%) of PCOS subjects were with overweight or obese. BMI mean value was (28.92±6.68) in women with PCOS, while in control the corresponding value was (25.09±4.35). FSH, and testosterone were significantly higher in women with PCOS than in control. Metformin reduced serum FSH, LH, prolactin and testosterone, with non-significant difference. Conclusion: PCOS is independently associated with elevated BMI. Metformin treatment of PCOS induced t reduction in serum testosterone and FSH, LH and serum prolactin but not reach significant level. This warranted performance a large scale clinical trial to evaluate the therapeutic effect of metformin alone or in combination with diet control approach for treatment of PCOS. These findings have implications for the pathophysiology of obesity development and management in PCOS.
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| format | Article |
| id | doaj-art-3ecd3ce3b449402c99ee1306895af249 |
| institution | Kabale University |
| issn | 1813-1662 2415-1726 |
| language | English |
| publishDate | 2023-02-01 |
| publisher | Tikrit University |
| record_format | Article |
| series | Tikrit Journal of Pure Science |
| spelling | doaj-art-3ecd3ce3b449402c99ee1306895af2492025-08-20T03:29:02ZengTikrit UniversityTikrit Journal of Pure Science1813-16622415-17262023-02-0122910.25130/tjps.v22i9.865EVALUATION THE EFFECT OF METFORMIN ON HORMONES SERUM LEVELS IN WOMEN WITH POLYCYSTIC OVARY SYNDROMELiqaa S. BaqerMutaz S. AhmeidAmena H. Al-Obaidi Background: Polycystic ovary syndrome [PCOS] is a common disease that affected the reproductive problem. Aim: the study tried to determine the association between PCOS with the body mass index (BMI) and the effect of metformin as treatment for PCOS. Patients and Methods: This case control prospective experimental study was carried out in Kirkuk General Hospital from January 2014 to July 2014. The recruited cases divided into three groups; Group I, 68 women with normal menstrual cycle as control group; Group II, 61 cases diagnosed as a PCOS; and Group III :- 30 cases selected from group two to receive treatment with Metformin to determine the effect of the treatment on different variables. Results: The highest percentage of PCOS (36.1%) was found in those with age group between (20-25) years. Most (65.6%) of PCOS subjects were with overweight or obese. BMI mean value was (28.92±6.68) in women with PCOS, while in control the corresponding value was (25.09±4.35). FSH, and testosterone were significantly higher in women with PCOS than in control. Metformin reduced serum FSH, LH, prolactin and testosterone, with non-significant difference. Conclusion: PCOS is independently associated with elevated BMI. Metformin treatment of PCOS induced t reduction in serum testosterone and FSH, LH and serum prolactin but not reach significant level. This warranted performance a large scale clinical trial to evaluate the therapeutic effect of metformin alone or in combination with diet control approach for treatment of PCOS. These findings have implications for the pathophysiology of obesity development and management in PCOS. https://tjpsj.org/index.php/tjps/article/view/865PCOSMetforminFSHLHProlactinTestosterone |
| spellingShingle | Liqaa S. Baqer Mutaz S. Ahmeid Amena H. Al-Obaidi EVALUATION THE EFFECT OF METFORMIN ON HORMONES SERUM LEVELS IN WOMEN WITH POLYCYSTIC OVARY SYNDROME Tikrit Journal of Pure Science PCOS Metformin FSH LH Prolactin Testosterone |
| title | EVALUATION THE EFFECT OF METFORMIN ON HORMONES SERUM LEVELS IN WOMEN WITH POLYCYSTIC OVARY SYNDROME |
| title_full | EVALUATION THE EFFECT OF METFORMIN ON HORMONES SERUM LEVELS IN WOMEN WITH POLYCYSTIC OVARY SYNDROME |
| title_fullStr | EVALUATION THE EFFECT OF METFORMIN ON HORMONES SERUM LEVELS IN WOMEN WITH POLYCYSTIC OVARY SYNDROME |
| title_full_unstemmed | EVALUATION THE EFFECT OF METFORMIN ON HORMONES SERUM LEVELS IN WOMEN WITH POLYCYSTIC OVARY SYNDROME |
| title_short | EVALUATION THE EFFECT OF METFORMIN ON HORMONES SERUM LEVELS IN WOMEN WITH POLYCYSTIC OVARY SYNDROME |
| title_sort | evaluation the effect of metformin on hormones serum levels in women with polycystic ovary syndrome |
| topic | PCOS Metformin FSH LH Prolactin Testosterone |
| url | https://tjpsj.org/index.php/tjps/article/view/865 |
| work_keys_str_mv | AT liqaasbaqer evaluationtheeffectofmetforminonhormonesserumlevelsinwomenwithpolycysticovarysyndrome AT mutazsahmeid evaluationtheeffectofmetforminonhormonesserumlevelsinwomenwithpolycysticovarysyndrome AT amenahalobaidi evaluationtheeffectofmetforminonhormonesserumlevelsinwomenwithpolycysticovarysyndrome |