STAT3: Key targets of growth-promoting receptor positive breast cancer
Abstract Breast cancer has become the malignant tumor with the first incidence and the second mortality among female cancers. Most female breast cancers belong to luminal-type breast cancer and HER2-positive breast cancer. These breast cancer cells all have different driving genes, which constantly...
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| Format: | Article |
| Language: | English |
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BMC
2024-10-01
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| Series: | Cancer Cell International |
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| Online Access: | https://doi.org/10.1186/s12935-024-03541-9 |
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| author | Rui-yuan Jiang Jia-yu Zhu Huan-ping Zhang Yuan Yu Zhi-xin Dong Huan-huan Zhou Xiaojia Wang |
| author_facet | Rui-yuan Jiang Jia-yu Zhu Huan-ping Zhang Yuan Yu Zhi-xin Dong Huan-huan Zhou Xiaojia Wang |
| author_sort | Rui-yuan Jiang |
| collection | DOAJ |
| description | Abstract Breast cancer has become the malignant tumor with the first incidence and the second mortality among female cancers. Most female breast cancers belong to luminal-type breast cancer and HER2-positive breast cancer. These breast cancer cells all have different driving genes, which constantly promote the proliferation and metastasis of breast cancer cells. Signal transducer and activator of transcription 3 (STAT3) is an important breast cancer-related gene, which can promote the progress of breast cancer. It has been proved in clinical and basic research that over-expressed and constitutively activated STAT3 is involved in the progress, proliferation, metastasis and chemotherapy resistance of breast cancer. STAT3 is an important key target in luminal-type breast cancer and HER2-positive cancer, which has an important impact on the curative effect of related treatments. In breast cancer, the activation of STAT3 will change the spatial position of STAT3 protein and cause different phenotypic changes of breast cancer cells. In the current basic research and clinical research, small molecule inhibitors activated by targeting STAT3 can effectively treat breast cancer, and enhance the efficacy level of related treatment methods for luminal-type and HER2-positive breast cancers. |
| format | Article |
| id | doaj-art-3ecbc65b73c8416ca236497f5343ff99 |
| institution | OA Journals |
| issn | 1475-2867 |
| language | English |
| publishDate | 2024-10-01 |
| publisher | BMC |
| record_format | Article |
| series | Cancer Cell International |
| spelling | doaj-art-3ecbc65b73c8416ca236497f5343ff992025-08-20T02:18:25ZengBMCCancer Cell International1475-28672024-10-0124114110.1186/s12935-024-03541-9STAT3: Key targets of growth-promoting receptor positive breast cancerRui-yuan Jiang0Jia-yu Zhu1Huan-ping Zhang2Yuan Yu3Zhi-xin Dong4Huan-huan Zhou5Xiaojia Wang6The Second School of Clinical Medicine, Zhejiang Chinese Medical UniversityThe Second School of Clinical Medicine, Zhejiang Chinese Medical UniversityZhejiang Cancer Hospital, Hangzhou Institute of Medicine (HIM), Chinese Academy of SciencesZhejiang Cancer Hospital, Hangzhou Institute of Medicine (HIM), Chinese Academy of SciencesDepartment of Oncology, The First Affiliated Hospital of Guangxi University of Chinese MedicineThe Second School of Clinical Medicine, Zhejiang Chinese Medical UniversityZhejiang Cancer Hospital, Hangzhou Institute of Medicine (HIM), Chinese Academy of SciencesAbstract Breast cancer has become the malignant tumor with the first incidence and the second mortality among female cancers. Most female breast cancers belong to luminal-type breast cancer and HER2-positive breast cancer. These breast cancer cells all have different driving genes, which constantly promote the proliferation and metastasis of breast cancer cells. Signal transducer and activator of transcription 3 (STAT3) is an important breast cancer-related gene, which can promote the progress of breast cancer. It has been proved in clinical and basic research that over-expressed and constitutively activated STAT3 is involved in the progress, proliferation, metastasis and chemotherapy resistance of breast cancer. STAT3 is an important key target in luminal-type breast cancer and HER2-positive cancer, which has an important impact on the curative effect of related treatments. In breast cancer, the activation of STAT3 will change the spatial position of STAT3 protein and cause different phenotypic changes of breast cancer cells. In the current basic research and clinical research, small molecule inhibitors activated by targeting STAT3 can effectively treat breast cancer, and enhance the efficacy level of related treatment methods for luminal-type and HER2-positive breast cancers.https://doi.org/10.1186/s12935-024-03541-9STAT3Breast cancerOncogeneGrowth-promotingCell growthSmall molecule inhibitors |
| spellingShingle | Rui-yuan Jiang Jia-yu Zhu Huan-ping Zhang Yuan Yu Zhi-xin Dong Huan-huan Zhou Xiaojia Wang STAT3: Key targets of growth-promoting receptor positive breast cancer Cancer Cell International STAT3 Breast cancer Oncogene Growth-promoting Cell growth Small molecule inhibitors |
| title | STAT3: Key targets of growth-promoting receptor positive breast cancer |
| title_full | STAT3: Key targets of growth-promoting receptor positive breast cancer |
| title_fullStr | STAT3: Key targets of growth-promoting receptor positive breast cancer |
| title_full_unstemmed | STAT3: Key targets of growth-promoting receptor positive breast cancer |
| title_short | STAT3: Key targets of growth-promoting receptor positive breast cancer |
| title_sort | stat3 key targets of growth promoting receptor positive breast cancer |
| topic | STAT3 Breast cancer Oncogene Growth-promoting Cell growth Small molecule inhibitors |
| url | https://doi.org/10.1186/s12935-024-03541-9 |
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