Young apple polyphenol extract prevents diabetic cognitive dysfunction by promoting TET2-mediated active DNA demethylation in the brain of diabetic mice

Young apple polyphenol extract prevents diabetic cognitive dysfunction by promoting TET2-mediated active DNA demethylation in the brain of diabetic mice

IntroductionDiabetic cognitive dysfunction (DCD) refers to the impairment of cognitive function resulting from diabetes. The increasing prevalence of diabetes and the aging population have rendered DCD a significant threat to brain health. Young apple polyphenol extract (YAPE) has demonstrated poten...

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Bibliographic Details
Main Authors:	Jiacheng Fang, Xiaochen Zhang, Zhongshi Qi, Liying Zhou, Yuntiao Chen, Qingxin Li, Run Liu, Hongzhuan Yu
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2025-05-01
Series:	Frontiers in Nutrition
Subjects:	diabetic cognitive dysfunction active DNA demethylation ten-eleven translocation protein 2 young apple polyphenol extract mitochondrion
Online Access:	https://www.frontiersin.org/articles/10.3389/fnut.2025.1580775/full
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