Targeting Signaling Pathways in Cancer Stem Cells for Cancer Treatment
The Wnt, Hedgehog, and Notch pathways are inherent signaling pathways in normal embryogenesis, development, and hemostasis. However, dysfunctions of these pathways are evident in multiple tumor types and malignancies. Specifically, aberrant activation of these pathways is implicated in modulation of...
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| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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Wiley
2017-01-01
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| Series: | Stem Cells International |
| Online Access: | http://dx.doi.org/10.1155/2017/2925869 |
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| _version_ | 1832553534213586944 |
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| author | Jeffrey Koury Li Zhong Jijun Hao |
| author_facet | Jeffrey Koury Li Zhong Jijun Hao |
| author_sort | Jeffrey Koury |
| collection | DOAJ |
| description | The Wnt, Hedgehog, and Notch pathways are inherent signaling pathways in normal embryogenesis, development, and hemostasis. However, dysfunctions of these pathways are evident in multiple tumor types and malignancies. Specifically, aberrant activation of these pathways is implicated in modulation of cancer stem cells (CSCs), a small subset of cancer cells capable of self-renewal and differentiation into heterogeneous tumor cells. The CSCs are accountable for tumor initiation, growth, and recurrence. In this review, we focus on roles of Wnt, Hedgehog, and Notch pathways in CSCs’ stemness and functions and summarize therapeutic studies targeting these pathways to eliminate CSCs and improve overall cancer treatment outcomes. |
| format | Article |
| id | doaj-art-3ec2311db55a4fd2a5636998d37fb826 |
| institution | Kabale University |
| issn | 1687-966X 1687-9678 |
| language | English |
| publishDate | 2017-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Stem Cells International |
| spelling | doaj-art-3ec2311db55a4fd2a5636998d37fb8262025-02-03T05:53:43ZengWileyStem Cells International1687-966X1687-96782017-01-01201710.1155/2017/29258692925869Targeting Signaling Pathways in Cancer Stem Cells for Cancer TreatmentJeffrey Koury0Li Zhong1Jijun Hao2Graduate College of Biomedical Sciences, Western University of Health Sciences, Pomona, CA 91766, USADepartment of Cell Biology, College of Life Sciences, Hebei University, Baoding, Hebei, ChinaGraduate College of Biomedical Sciences, Western University of Health Sciences, Pomona, CA 91766, USAThe Wnt, Hedgehog, and Notch pathways are inherent signaling pathways in normal embryogenesis, development, and hemostasis. However, dysfunctions of these pathways are evident in multiple tumor types and malignancies. Specifically, aberrant activation of these pathways is implicated in modulation of cancer stem cells (CSCs), a small subset of cancer cells capable of self-renewal and differentiation into heterogeneous tumor cells. The CSCs are accountable for tumor initiation, growth, and recurrence. In this review, we focus on roles of Wnt, Hedgehog, and Notch pathways in CSCs’ stemness and functions and summarize therapeutic studies targeting these pathways to eliminate CSCs and improve overall cancer treatment outcomes.http://dx.doi.org/10.1155/2017/2925869 |
| spellingShingle | Jeffrey Koury Li Zhong Jijun Hao Targeting Signaling Pathways in Cancer Stem Cells for Cancer Treatment Stem Cells International |
| title | Targeting Signaling Pathways in Cancer Stem Cells for Cancer Treatment |
| title_full | Targeting Signaling Pathways in Cancer Stem Cells for Cancer Treatment |
| title_fullStr | Targeting Signaling Pathways in Cancer Stem Cells for Cancer Treatment |
| title_full_unstemmed | Targeting Signaling Pathways in Cancer Stem Cells for Cancer Treatment |
| title_short | Targeting Signaling Pathways in Cancer Stem Cells for Cancer Treatment |
| title_sort | targeting signaling pathways in cancer stem cells for cancer treatment |
| url | http://dx.doi.org/10.1155/2017/2925869 |
| work_keys_str_mv | AT jeffreykoury targetingsignalingpathwaysincancerstemcellsforcancertreatment AT lizhong targetingsignalingpathwaysincancerstemcellsforcancertreatment AT jijunhao targetingsignalingpathwaysincancerstemcellsforcancertreatment |