Experience of polymyositis and antisynthetase syndrome treatment with rituximab
The patient with polymyositis and antisynthetase syndrome treated with rituximab (Mabtera) is described. Rituximab was added to thehigh‑dose cyclophosphamide therapy due to an acute onset of the disease with a highly progressive interstitial lung disease and inability of the high‑dose corticosteroid...
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| Format: | Article |
| Language: | Russian |
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ABV-press
2015-02-01
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| Series: | Нервно-мышечные болезни |
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| Online Access: | https://nmb.abvpress.ru/jour/article/view/88 |
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| author | S. G. Palshina S. S. Nikitin V. I. Vasilyev |
| author_facet | S. G. Palshina S. S. Nikitin V. I. Vasilyev |
| author_sort | S. G. Palshina |
| collection | DOAJ |
| description | The patient with polymyositis and antisynthetase syndrome treated with rituximab (Mabtera) is described. Rituximab was added to thehigh‑dose cyclophosphamide therapy due to an acute onset of the disease with a highly progressive interstitial lung disease and inability of the high‑dose corticosteroids therapy because of comorbidity. There was almost complete normalization of pulmonary and muscular pathological changes with more than 4‑fold decrease of anti‑Jo‑1 antibodies on the treatment. No complications and no side effects during rituximab therapy were noted. This case report demonstrates the positive effect of rituximab in combination with high‑dose cyclophosphamide in the treatment of acute AS syndrome. The results published in literature are discussed. |
| format | Article |
| id | doaj-art-3ebfd42a292240f2bd500f5609cd708c |
| institution | Kabale University |
| issn | 2222-8721 2413-0443 |
| language | Russian |
| publishDate | 2015-02-01 |
| publisher | ABV-press |
| record_format | Article |
| series | Нервно-мышечные болезни |
| spelling | doaj-art-3ebfd42a292240f2bd500f5609cd708c2025-08-20T04:00:20ZrusABV-pressНервно-мышечные болезни2222-87212413-04432015-02-0103455410.17650/2222-8721-2012-0-3-45-5482Experience of polymyositis and antisynthetase syndrome treatment with rituximabS. G. Palshina0S. S. Nikitin1V. I. Vasilyev2Research Institute of Rheumatology of Russian Academy of Medical SciencesThe Institute of General Pathology and Pathophysiology of Russian Academy of Medical Sciences, MoscowResearch Institute of Rheumatology of Russian Academy of Medical SciencesThe patient with polymyositis and antisynthetase syndrome treated with rituximab (Mabtera) is described. Rituximab was added to thehigh‑dose cyclophosphamide therapy due to an acute onset of the disease with a highly progressive interstitial lung disease and inability of the high‑dose corticosteroids therapy because of comorbidity. There was almost complete normalization of pulmonary and muscular pathological changes with more than 4‑fold decrease of anti‑Jo‑1 antibodies on the treatment. No complications and no side effects during rituximab therapy were noted. This case report demonstrates the positive effect of rituximab in combination with high‑dose cyclophosphamide in the treatment of acute AS syndrome. The results published in literature are discussed.https://nmb.abvpress.ru/jour/article/view/88antisynthetase syndromeidiopathic inflammatory myopathypolymyositisdermatomyositisrituximab |
| spellingShingle | S. G. Palshina S. S. Nikitin V. I. Vasilyev Experience of polymyositis and antisynthetase syndrome treatment with rituximab Нервно-мышечные болезни antisynthetase syndrome idiopathic inflammatory myopathy polymyositis dermatomyositis rituximab |
| title | Experience of polymyositis and antisynthetase syndrome treatment with rituximab |
| title_full | Experience of polymyositis and antisynthetase syndrome treatment with rituximab |
| title_fullStr | Experience of polymyositis and antisynthetase syndrome treatment with rituximab |
| title_full_unstemmed | Experience of polymyositis and antisynthetase syndrome treatment with rituximab |
| title_short | Experience of polymyositis and antisynthetase syndrome treatment with rituximab |
| title_sort | experience of polymyositis and antisynthetase syndrome treatment with rituximab |
| topic | antisynthetase syndrome idiopathic inflammatory myopathy polymyositis dermatomyositis rituximab |
| url | https://nmb.abvpress.ru/jour/article/view/88 |
| work_keys_str_mv | AT sgpalshina experienceofpolymyositisandantisynthetasesyndrometreatmentwithrituximab AT ssnikitin experienceofpolymyositisandantisynthetasesyndrometreatmentwithrituximab AT vivasilyev experienceofpolymyositisandantisynthetasesyndrometreatmentwithrituximab |