Trajectory analysis of hepatic stellate cell differentiation reveals metabolic regulation of cell commitment and fibrosis

Trajectory analysis of hepatic stellate cell differentiation reveals metabolic regulation of cell commitment and fibrosis

Abstract Defining the trajectory of cells during differentiation and disease is key for uncovering the mechanisms driving cell fate and identity. However, trajectories of human cells remain largely unexplored due to the challenges of studying them with human samples. In this study, we investigate th...

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Main Authors: Raquel A. Martínez García de la Torre, Julia Vallverdú, Zhenqing Xu, Silvia Ariño, Raquel Ferrer-Lorente, Laura Zanatto, Maria Mercado-Gómez, Beatriz Aguilar-Bravo, Paloma Ruiz-Blázquez, Maria Fernandez- Fernandez, Artur Navarro-Gascon, Albert Blasco-Roset, Paula Sànchez-Fernàndez-de-Landa, Joan Pera, Damia Romero-Moya, Paula Ayuso Garcia, Celia Martínez Sánchez, Laura Sererols Viñas, Paula Cantallops Vilà, Carmen I. Cárcamo Giráldez, Andrew McQuillin, Marsha Y. Morgan, Daniel Moya-Rull, Núria Montserrat, Delphine Eberlé, Bart Staels, Bénédicte Antoine, Mikel Azkargorta, Juan-José Lozano, Maria L. Martínez-Chantar, Alessandra Giorgetti, Félix Elortza, Anna Planavila, Marta Varela-Rey, Ashwin Woodhoo, Antonio Zorzano, Isabel Graupera, Anna Moles, Mar Coll, Silvia Affo, Pau Sancho-Bru
Format: Article
Language:English
Published: Nature Portfolio 2025-02-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-025-56024-4
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