A Comprehensive Review of the Phytochemistry and Therapeutic Efficacy of <i>Viola yedoensis</i> Makino
<i>Viola yedoensis</i> Makino (<i>V. yedoensis</i>), a perennial herb in the Violaceae family, is recognized for its violet flowers and has a longstanding role in ethnomedicine for treating various inflammatory diseases, such as boils, furuncles, carbuncles, and both acute an...
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2025-04-01
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| author | Shuang Wang Congcong Shen Shengyu Zhang Han Di Yanhong Wang Feng Guan |
| author_facet | Shuang Wang Congcong Shen Shengyu Zhang Han Di Yanhong Wang Feng Guan |
| author_sort | Shuang Wang |
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| description | <i>Viola yedoensis</i> Makino (<i>V. yedoensis</i>), a perennial herb in the Violaceae family, is recognized for its violet flowers and has a longstanding role in ethnomedicine for treating various inflammatory diseases, such as boils, furuncles, carbuncles, and both acute and chronic hepatitis, among others. A comprehensive literature review was conducted utilizing resources including the Chinese Pharmacopoeia, Flora of China, Web of Science, PubMed, Baidu Scholar, Google Scholar, and China National Knowledge Infrastructure (CNKI). This paper serves as the inaugural comprehensive review of the latest findings regarding the botany, traditional applications, phytochemistry, pharmacological properties, quality control, and prospective uses of <i>V. yedoensis</i>. The objective is to provide a robust foundation for future research and to suggest novel avenues for exploring its potential applications. To date, 162 chemical constituents have been isolated from <i>V. yedoensis</i>, with flavonoids and coumarins identified as particularly abundant. These compounds exhibit promising activities, including anti-inflammatory, anti-pyretic, anti-viral, anti-tumor, anti-lung injury, anti-liver injury, anti-bacterial, anti-coagulant, anti-complement, and anti-oxidant properties. Despite considerable advancements in fundamental research on <i>V. yedoensis</i>, further investigations are required to elucidate the underlying mechanisms of action and to discover additional uncharacterized compounds. This review underscores the plant’s significant development potential, highlighting the necessity for more in-depth exploration. |
| format | Article |
| id | doaj-art-3ebe571a002f45a9ac5ddac986bdfc9b |
| institution | DOAJ |
| issn | 1420-3049 |
| language | English |
| publishDate | 2025-04-01 |
| publisher | MDPI AG |
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| series | Molecules |
| spelling | doaj-art-3ebe571a002f45a9ac5ddac986bdfc9b2025-08-20T02:59:14ZengMDPI AGMolecules1420-30492025-04-01309192210.3390/molecules30091922A Comprehensive Review of the Phytochemistry and Therapeutic Efficacy of <i>Viola yedoensis</i> MakinoShuang Wang0Congcong Shen1Shengyu Zhang2Han Di3Yanhong Wang4Feng Guan5School of Pharmacy, Heilongjiang University of Chinese Medicine, 24 Heping Road, Xiangfang District, Harbin 150040, ChinaSchool of Pharmacy, Heilongjiang University of Chinese Medicine, 24 Heping Road, Xiangfang District, Harbin 150040, ChinaSchool of Pharmacy, Heilongjiang University of Chinese Medicine, 24 Heping Road, Xiangfang District, Harbin 150040, ChinaSchool of Pharmacy, Heilongjiang University of Chinese Medicine, 24 Heping Road, Xiangfang District, Harbin 150040, ChinaSchool of Pharmacy, Heilongjiang University of Chinese Medicine, 24 Heping Road, Xiangfang District, Harbin 150040, ChinaSchool of Pharmacy, Heilongjiang University of Chinese Medicine, 24 Heping Road, Xiangfang District, Harbin 150040, China<i>Viola yedoensis</i> Makino (<i>V. yedoensis</i>), a perennial herb in the Violaceae family, is recognized for its violet flowers and has a longstanding role in ethnomedicine for treating various inflammatory diseases, such as boils, furuncles, carbuncles, and both acute and chronic hepatitis, among others. A comprehensive literature review was conducted utilizing resources including the Chinese Pharmacopoeia, Flora of China, Web of Science, PubMed, Baidu Scholar, Google Scholar, and China National Knowledge Infrastructure (CNKI). This paper serves as the inaugural comprehensive review of the latest findings regarding the botany, traditional applications, phytochemistry, pharmacological properties, quality control, and prospective uses of <i>V. yedoensis</i>. The objective is to provide a robust foundation for future research and to suggest novel avenues for exploring its potential applications. To date, 162 chemical constituents have been isolated from <i>V. yedoensis</i>, with flavonoids and coumarins identified as particularly abundant. These compounds exhibit promising activities, including anti-inflammatory, anti-pyretic, anti-viral, anti-tumor, anti-lung injury, anti-liver injury, anti-bacterial, anti-coagulant, anti-complement, and anti-oxidant properties. Despite considerable advancements in fundamental research on <i>V. yedoensis</i>, further investigations are required to elucidate the underlying mechanisms of action and to discover additional uncharacterized compounds. This review underscores the plant’s significant development potential, highlighting the necessity for more in-depth exploration.https://www.mdpi.com/1420-3049/30/9/1922<i>Viola yedoensis</i> Makinobotanytraditional usesphytochemistrypharmacologyquality control |
| spellingShingle | Shuang Wang Congcong Shen Shengyu Zhang Han Di Yanhong Wang Feng Guan A Comprehensive Review of the Phytochemistry and Therapeutic Efficacy of <i>Viola yedoensis</i> Makino Molecules <i>Viola yedoensis</i> Makino botany traditional uses phytochemistry pharmacology quality control |
| title | A Comprehensive Review of the Phytochemistry and Therapeutic Efficacy of <i>Viola yedoensis</i> Makino |
| title_full | A Comprehensive Review of the Phytochemistry and Therapeutic Efficacy of <i>Viola yedoensis</i> Makino |
| title_fullStr | A Comprehensive Review of the Phytochemistry and Therapeutic Efficacy of <i>Viola yedoensis</i> Makino |
| title_full_unstemmed | A Comprehensive Review of the Phytochemistry and Therapeutic Efficacy of <i>Viola yedoensis</i> Makino |
| title_short | A Comprehensive Review of the Phytochemistry and Therapeutic Efficacy of <i>Viola yedoensis</i> Makino |
| title_sort | comprehensive review of the phytochemistry and therapeutic efficacy of i viola yedoensis i makino |
| topic | <i>Viola yedoensis</i> Makino botany traditional uses phytochemistry pharmacology quality control |
| url | https://www.mdpi.com/1420-3049/30/9/1922 |
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