Activation and Molecular Targets of Peroxisome Proliferator-Activated Receptor-γ Ligands in Lung Cancer
Lung cancer is the leading cause of cancer death, and five-year survival remains poor, raising the urgency for new treatment strategies. Activation of PPARγ represents a potential target for both the treatment and prevention of lung cancer. Numerous studies have examined the effect of thiazolidinedi...
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| Format: | Article |
| Language: | English |
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Wiley
2008-01-01
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| Series: | PPAR Research |
| Online Access: | http://dx.doi.org/10.1155/2008/156875 |
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| _version_ | 1850216218484539392 |
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| author | Raphael A. Nemenoff Mary Weiser-Evans Robert A. Winn |
| author_facet | Raphael A. Nemenoff Mary Weiser-Evans Robert A. Winn |
| author_sort | Raphael A. Nemenoff |
| collection | DOAJ |
| description | Lung cancer is the leading cause of cancer death, and five-year survival remains poor, raising the urgency for new treatment strategies. Activation of PPARγ represents a potential target for both the treatment and prevention of lung cancer. Numerous studies have examined the effect of thiazolidinediones such as rosiglitazone and pioglitazone on lung cancer cells in vitro and in xenograft models. These studies indicate that activation of PPARγ inhibits cancer cell proliferation as well as invasiveness and metastasis. While activation of PPARγ can occur by direct binding of pharmacological ligands to the molecule, emerging data indicate that PPARγ activation can occur through engagement of other signal transduction pathways, including Wnt signaling and prostaglandin production. Data, both from preclinical models and retrospective clinical studies, indicate that activation of PPARγ may represent an attractive chemopreventive strategy. This article reviews the existing biological and mechanistic experiments focusing on the role of PPARγ in lung cancer, focusing specifically on nonsmall cell lung cancer. |
| format | Article |
| id | doaj-art-3ebc5dcc60c14b3b815fbf3d40895990 |
| institution | OA Journals |
| issn | 1687-4757 1687-4765 |
| language | English |
| publishDate | 2008-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | PPAR Research |
| spelling | doaj-art-3ebc5dcc60c14b3b815fbf3d408959902025-08-20T02:08:23ZengWileyPPAR Research1687-47571687-47652008-01-01200810.1155/2008/156875156875Activation and Molecular Targets of Peroxisome Proliferator-Activated Receptor-γ Ligands in Lung CancerRaphael A. Nemenoff0Mary Weiser-Evans1Robert A. Winn2Division of Renal Diseases, Department of Medicine, School of Medicine, University of Colorado Denver, Denver, CO 80262, USADivision of Renal Diseases, Department of Medicine, School of Medicine, University of Colorado Denver, Denver, CO 80262, USADivision of Hypertension and Pulmonary Sciences and Critical Care, Department of Medicine, School of Medicine, University of Colorado Denver, Denver, CO 80262, USALung cancer is the leading cause of cancer death, and five-year survival remains poor, raising the urgency for new treatment strategies. Activation of PPARγ represents a potential target for both the treatment and prevention of lung cancer. Numerous studies have examined the effect of thiazolidinediones such as rosiglitazone and pioglitazone on lung cancer cells in vitro and in xenograft models. These studies indicate that activation of PPARγ inhibits cancer cell proliferation as well as invasiveness and metastasis. While activation of PPARγ can occur by direct binding of pharmacological ligands to the molecule, emerging data indicate that PPARγ activation can occur through engagement of other signal transduction pathways, including Wnt signaling and prostaglandin production. Data, both from preclinical models and retrospective clinical studies, indicate that activation of PPARγ may represent an attractive chemopreventive strategy. This article reviews the existing biological and mechanistic experiments focusing on the role of PPARγ in lung cancer, focusing specifically on nonsmall cell lung cancer.http://dx.doi.org/10.1155/2008/156875 |
| spellingShingle | Raphael A. Nemenoff Mary Weiser-Evans Robert A. Winn Activation and Molecular Targets of Peroxisome Proliferator-Activated Receptor-γ Ligands in Lung Cancer PPAR Research |
| title | Activation and Molecular Targets of Peroxisome Proliferator-Activated Receptor-γ Ligands in Lung Cancer |
| title_full | Activation and Molecular Targets of Peroxisome Proliferator-Activated Receptor-γ Ligands in Lung Cancer |
| title_fullStr | Activation and Molecular Targets of Peroxisome Proliferator-Activated Receptor-γ Ligands in Lung Cancer |
| title_full_unstemmed | Activation and Molecular Targets of Peroxisome Proliferator-Activated Receptor-γ Ligands in Lung Cancer |
| title_short | Activation and Molecular Targets of Peroxisome Proliferator-Activated Receptor-γ Ligands in Lung Cancer |
| title_sort | activation and molecular targets of peroxisome proliferator activated receptor γ ligands in lung cancer |
| url | http://dx.doi.org/10.1155/2008/156875 |
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