Impact of treatment time and waiting time on outcome for esophageal squamous cell carcinoma receiving definitive chemoradiotherapy
Abstract Purpose To assess the effect of treatment time and waiting time on clinical outcome for patients with esophageal squamous cell carcinoma (ESCC) treated with definitive concurrent chemoradiotherapy (CCRT). Methods and materials A retrospective analysis was conducted on ESCC patients treated...
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| Format: | Article |
| Language: | English |
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BMC
2025-07-01
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| Series: | Radiation Oncology |
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| Online Access: | https://doi.org/10.1186/s13014-025-02687-8 |
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| author | Geng Xiang Xiaomeng Wang Cong Zhang Guangjin Chai Bo Lyu Yutian Yin Bin Wang Lina Zhao |
| author_facet | Geng Xiang Xiaomeng Wang Cong Zhang Guangjin Chai Bo Lyu Yutian Yin Bin Wang Lina Zhao |
| author_sort | Geng Xiang |
| collection | DOAJ |
| description | Abstract Purpose To assess the effect of treatment time and waiting time on clinical outcome for patients with esophageal squamous cell carcinoma (ESCC) treated with definitive concurrent chemoradiotherapy (CCRT). Methods and materials A retrospective analysis was conducted on ESCC patients treated with definitive CCRT between 2008 and 2024 at Xijing hospital. Analyses were performed according to the following separate definitions of treatment time and waiting time: (1) theoretical minimal radiotherapy time (TMRT); (2) overall treatment time (OTT); (3) exceeding time (ET); (4) time to start of radiotherapy (TSR); (5) overall waiting time (OWT). Associations between treatment time and waiting time and survival outcome were investigated using Cox regression analyses. Results A total of 541 patients were studied and prolonged treatment time and waiting time were common. Overall, the median TMRT, OTT, ET, TSR, and OWT were 38 days [interquartile range (IQR): 38–40 days], 43 days (IQR: 40–47 days), 4 days (IQR: 2–7 days), 88 days (IQR: 62–126 days), and 21 days (IQR: 14–31 days), respectively. Multivariate analysis revealed that delay of treatment time and waiting time has no effect on overall survival (OS), locoregional relapse-free survival (LRFS), distant metastasis-free survival (DMFS), and progression-free survival (PFS) (all p > 0.05). In the subgroup of patients with T1-2 ESCC disease, the TSR < 72 days group had significantly more favorable OS (p = 0.009), LRFS (p = 0.003), and PFS (p = 0.022) compared with TSR ≥ 72 days group. Conclusions Delay of treatment time and waiting time has no effect on OS, LRFS, DMFS, and PFS. However, longer TSR was found to be associated with diminished survival outcomes for T1-2 stage rather than T3-4 ESCC patients treated with definitive CCRT. |
| format | Article |
| id | doaj-art-3eba83bd3a284827a0208a64139e763b |
| institution | Kabale University |
| issn | 1748-717X |
| language | English |
| publishDate | 2025-07-01 |
| publisher | BMC |
| record_format | Article |
| series | Radiation Oncology |
| spelling | doaj-art-3eba83bd3a284827a0208a64139e763b2025-08-20T03:46:12ZengBMCRadiation Oncology1748-717X2025-07-0120111010.1186/s13014-025-02687-8Impact of treatment time and waiting time on outcome for esophageal squamous cell carcinoma receiving definitive chemoradiotherapyGeng Xiang0Xiaomeng Wang1Cong Zhang2Guangjin Chai3Bo Lyu4Yutian Yin5Bin Wang6Lina Zhao7Department of Radiation Oncology, Xijing Hospital, Air Force Medical UniversityDepartment of Radiation Oncology, Xijing Hospital, Air Force Medical UniversityDepartment of Radiation Oncology, Xijing Hospital, Air Force Medical UniversityDepartment of Radiation Oncology, Xijing Hospital, Air Force Medical UniversityDepartment of Radiation Oncology, Xijing Hospital, Air Force Medical UniversityDepartment of Radiation Oncology, Xijing Hospital, Air Force Medical UniversityDepartment of Radiation Oncology, Xijing Hospital, Air Force Medical UniversityDepartment of Radiation Oncology, Xijing Hospital, Air Force Medical UniversityAbstract Purpose To assess the effect of treatment time and waiting time on clinical outcome for patients with esophageal squamous cell carcinoma (ESCC) treated with definitive concurrent chemoradiotherapy (CCRT). Methods and materials A retrospective analysis was conducted on ESCC patients treated with definitive CCRT between 2008 and 2024 at Xijing hospital. Analyses were performed according to the following separate definitions of treatment time and waiting time: (1) theoretical minimal radiotherapy time (TMRT); (2) overall treatment time (OTT); (3) exceeding time (ET); (4) time to start of radiotherapy (TSR); (5) overall waiting time (OWT). Associations between treatment time and waiting time and survival outcome were investigated using Cox regression analyses. Results A total of 541 patients were studied and prolonged treatment time and waiting time were common. Overall, the median TMRT, OTT, ET, TSR, and OWT were 38 days [interquartile range (IQR): 38–40 days], 43 days (IQR: 40–47 days), 4 days (IQR: 2–7 days), 88 days (IQR: 62–126 days), and 21 days (IQR: 14–31 days), respectively. Multivariate analysis revealed that delay of treatment time and waiting time has no effect on overall survival (OS), locoregional relapse-free survival (LRFS), distant metastasis-free survival (DMFS), and progression-free survival (PFS) (all p > 0.05). In the subgroup of patients with T1-2 ESCC disease, the TSR < 72 days group had significantly more favorable OS (p = 0.009), LRFS (p = 0.003), and PFS (p = 0.022) compared with TSR ≥ 72 days group. Conclusions Delay of treatment time and waiting time has no effect on OS, LRFS, DMFS, and PFS. However, longer TSR was found to be associated with diminished survival outcomes for T1-2 stage rather than T3-4 ESCC patients treated with definitive CCRT.https://doi.org/10.1186/s13014-025-02687-8Esophageal squamous cell carcinomaChemoradiotherapyTreatment timeWaiting timeOverall survival |
| spellingShingle | Geng Xiang Xiaomeng Wang Cong Zhang Guangjin Chai Bo Lyu Yutian Yin Bin Wang Lina Zhao Impact of treatment time and waiting time on outcome for esophageal squamous cell carcinoma receiving definitive chemoradiotherapy Radiation Oncology Esophageal squamous cell carcinoma Chemoradiotherapy Treatment time Waiting time Overall survival |
| title | Impact of treatment time and waiting time on outcome for esophageal squamous cell carcinoma receiving definitive chemoradiotherapy |
| title_full | Impact of treatment time and waiting time on outcome for esophageal squamous cell carcinoma receiving definitive chemoradiotherapy |
| title_fullStr | Impact of treatment time and waiting time on outcome for esophageal squamous cell carcinoma receiving definitive chemoradiotherapy |
| title_full_unstemmed | Impact of treatment time and waiting time on outcome for esophageal squamous cell carcinoma receiving definitive chemoradiotherapy |
| title_short | Impact of treatment time and waiting time on outcome for esophageal squamous cell carcinoma receiving definitive chemoradiotherapy |
| title_sort | impact of treatment time and waiting time on outcome for esophageal squamous cell carcinoma receiving definitive chemoradiotherapy |
| topic | Esophageal squamous cell carcinoma Chemoradiotherapy Treatment time Waiting time Overall survival |
| url | https://doi.org/10.1186/s13014-025-02687-8 |
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