The Prognostic Value of Transcutaneous Oxygen Pressure (TcPO<sub>2</sub>) in Diabetic Foot Ulcer Healing: A Protocol for a Systematic Review
<b>Background/Objectives:</b> Due to poor perfusion, diabetic foot ulcers (DFUs) create hypoxic environments, and their chronicity represents a negative factor in wound healing. Transcutaneous oxygen pressure (TcPO<sub>2</sub>) is a non-invasive method that provides informati...
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MDPI AG
2025-04-01
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| Online Access: | https://www.mdpi.com/2075-4418/15/7/909 |
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| author | Andrea Bordonado-Murcia Javier Marco-Lledó Pilar Nieto-Gil Luz Marina Zuluaga-Ríos Paloma López-Ros Irene Hernández-Martínez David Montoro-Cremades Jonatan García-Campos |
| author_facet | Andrea Bordonado-Murcia Javier Marco-Lledó Pilar Nieto-Gil Luz Marina Zuluaga-Ríos Paloma López-Ros Irene Hernández-Martínez David Montoro-Cremades Jonatan García-Campos |
| author_sort | Andrea Bordonado-Murcia |
| collection | DOAJ |
| description | <b>Background/Objectives:</b> Due to poor perfusion, diabetic foot ulcers (DFUs) create hypoxic environments, and their chronicity represents a negative factor in wound healing. Transcutaneous oxygen pressure (TcPO<sub>2</sub>) is a non-invasive method that provides information on oxygen supply to microvascular circulation, useful for determining the severity and progression of peripheral arterial disease (PAD) as well as potentially predicting DFU healing. However, the current literature does not provide strong support for the use of TcPO<sub>2</sub> as an independent predictive tool. <b>Methods:</b> This protocol aims to systematically review the available evidence according to PRISMA (2020) guidelines, registered with the International Prospective Register of Systematic Reviews (registration number: CRD42024505907). The following databases will be used: Cochrane Library, EMBASE, Ovid Medline, PubMed, and Web of Science. Additionally, a manual search will be conducted through the references of the included articles. <b>Results:</b> The systematic review will summarize the current evidence on the prognostic value of TcPO<sub>2</sub> in DFU healing, identifying gaps in knowledge and potential areas for future research. <b>Conclusions:</b> The findings of this study may clarify the prognostic value of TcPO<sub>2</sub> in DFU healing, which could ultimately facilitate clinical management, decision-making, patient care, and potentially reduce treatment costs. |
| format | Article |
| id | doaj-art-3eb9c0f6f4cc482f9bb38e55c6c8dd2d |
| institution | OA Journals |
| issn | 2075-4418 |
| language | English |
| publishDate | 2025-04-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Diagnostics |
| spelling | doaj-art-3eb9c0f6f4cc482f9bb38e55c6c8dd2d2025-08-20T02:15:55ZengMDPI AGDiagnostics2075-44182025-04-0115790910.3390/diagnostics15070909The Prognostic Value of Transcutaneous Oxygen Pressure (TcPO<sub>2</sub>) in Diabetic Foot Ulcer Healing: A Protocol for a Systematic ReviewAndrea Bordonado-Murcia0Javier Marco-Lledó1Pilar Nieto-Gil2Luz Marina Zuluaga-Ríos3Paloma López-Ros4Irene Hernández-Martínez5David Montoro-Cremades6Jonatan García-Campos7Private Practice, 03170 Rojales, SpainDepartment of Behavioral Sciences and Health, Miguel Hernandez University, 03550 Sant Joan, SpainFacultad de Enfermería y Podología, Universidad de Valencia, 46010 Valencia, SpainHospital San Juan de Dios, 760044 Cali, ColombiaDepartment of Behavioral Sciences and Health, Miguel Hernandez University, 03550 Sant Joan, SpainHospital IMED Elche, 03203 Elche, SpainHospital IMED Elche, 03203 Elche, SpainDepartment of Behavioral Sciences and Health, Miguel Hernandez University, 03550 Sant Joan, Spain<b>Background/Objectives:</b> Due to poor perfusion, diabetic foot ulcers (DFUs) create hypoxic environments, and their chronicity represents a negative factor in wound healing. Transcutaneous oxygen pressure (TcPO<sub>2</sub>) is a non-invasive method that provides information on oxygen supply to microvascular circulation, useful for determining the severity and progression of peripheral arterial disease (PAD) as well as potentially predicting DFU healing. However, the current literature does not provide strong support for the use of TcPO<sub>2</sub> as an independent predictive tool. <b>Methods:</b> This protocol aims to systematically review the available evidence according to PRISMA (2020) guidelines, registered with the International Prospective Register of Systematic Reviews (registration number: CRD42024505907). The following databases will be used: Cochrane Library, EMBASE, Ovid Medline, PubMed, and Web of Science. Additionally, a manual search will be conducted through the references of the included articles. <b>Results:</b> The systematic review will summarize the current evidence on the prognostic value of TcPO<sub>2</sub> in DFU healing, identifying gaps in knowledge and potential areas for future research. <b>Conclusions:</b> The findings of this study may clarify the prognostic value of TcPO<sub>2</sub> in DFU healing, which could ultimately facilitate clinical management, decision-making, patient care, and potentially reduce treatment costs.https://www.mdpi.com/2075-4418/15/7/909prognosistranscutaneousblood gas monitoringdiabetic footfoot ulcer |
| spellingShingle | Andrea Bordonado-Murcia Javier Marco-Lledó Pilar Nieto-Gil Luz Marina Zuluaga-Ríos Paloma López-Ros Irene Hernández-Martínez David Montoro-Cremades Jonatan García-Campos The Prognostic Value of Transcutaneous Oxygen Pressure (TcPO<sub>2</sub>) in Diabetic Foot Ulcer Healing: A Protocol for a Systematic Review Diagnostics prognosis transcutaneous blood gas monitoring diabetic foot foot ulcer |
| title | The Prognostic Value of Transcutaneous Oxygen Pressure (TcPO<sub>2</sub>) in Diabetic Foot Ulcer Healing: A Protocol for a Systematic Review |
| title_full | The Prognostic Value of Transcutaneous Oxygen Pressure (TcPO<sub>2</sub>) in Diabetic Foot Ulcer Healing: A Protocol for a Systematic Review |
| title_fullStr | The Prognostic Value of Transcutaneous Oxygen Pressure (TcPO<sub>2</sub>) in Diabetic Foot Ulcer Healing: A Protocol for a Systematic Review |
| title_full_unstemmed | The Prognostic Value of Transcutaneous Oxygen Pressure (TcPO<sub>2</sub>) in Diabetic Foot Ulcer Healing: A Protocol for a Systematic Review |
| title_short | The Prognostic Value of Transcutaneous Oxygen Pressure (TcPO<sub>2</sub>) in Diabetic Foot Ulcer Healing: A Protocol for a Systematic Review |
| title_sort | prognostic value of transcutaneous oxygen pressure tcpo sub 2 sub in diabetic foot ulcer healing a protocol for a systematic review |
| topic | prognosis transcutaneous blood gas monitoring diabetic foot foot ulcer |
| url | https://www.mdpi.com/2075-4418/15/7/909 |
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