Association between Growth Differentiation Factor-15 and Risk of Cardiovascular Diseases in Patients with Adult Growth Hormone Deficiency
Objective. Patients with adult growth hormone deficiency (AGHD) confer a heightened risk of cardiovascular disease and increased mortality because of metabolic disorders. Growth differentiation factor-15 (GDF-15) plays an important role in predicting metabolic abnormalities. We sought to investigate...
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| Format: | Article |
| Language: | English |
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Wiley
2021-01-01
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| Series: | International Journal of Endocrinology |
| Online Access: | http://dx.doi.org/10.1155/2021/5921863 |
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| _version_ | 1850216210642239488 |
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| author | Xun Wu Yunting Wang Ziyu Ren Linman Li Wenjie Qian Yue Chen Wei Ren |
| author_facet | Xun Wu Yunting Wang Ziyu Ren Linman Li Wenjie Qian Yue Chen Wei Ren |
| author_sort | Xun Wu |
| collection | DOAJ |
| description | Objective. Patients with adult growth hormone deficiency (AGHD) confer a heightened risk of cardiovascular disease and increased mortality because of metabolic disorders. Growth differentiation factor-15 (GDF-15) plays an important role in predicting metabolic abnormalities. We sought to investigate the correlation between GDF-15 and cardiovascular risk in AGHD patients. Methods. The study enrolled 80 AGHD patients and 80 healthy subjects. We analyzed the association between GDF-15 and some major biochemical indicators. The potential association between GDF-15 and cardiovascular disease risk was analyzed. Results. The AGHD group exhibited increased waist-hip ratio and high-sensitivity C-reactive protein (hs-CRP) and lipid levels compared with the healthy control group. Serum GDF-15 levels in AGHD group were elevated significantly compared with the control group P<0.001. GDF-15 levels were negatively associated with insulin-like growth factor-1 in AGHD group P=0.006 and positively correlated with waist-to-hip ratio P=0.018, triglycerides P=0.007, and hs-CRP P=0.046. In addition, GDF-15 was positively correlated with Framingham risk score significantly after adjustment for other factors (r = 0.497, P<0.001). Moreover, GDF-15 was an independent risk factor for cardiovascular disease in AGHD patients after adjusting for traditional cardiovascular risk factors. Conclusion. Elevated GDF-15 levels were significantly associated with cardiovascular risk factors and can be considered as a predictive biomarker of cardiovascular risk in AGHD patients. |
| format | Article |
| id | doaj-art-3eb5a50f373d40c284ed901fd04d7f6c |
| institution | OA Journals |
| issn | 1687-8337 1687-8345 |
| language | English |
| publishDate | 2021-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | International Journal of Endocrinology |
| spelling | doaj-art-3eb5a50f373d40c284ed901fd04d7f6c2025-08-20T02:08:23ZengWileyInternational Journal of Endocrinology1687-83371687-83452021-01-01202110.1155/2021/59218635921863Association between Growth Differentiation Factor-15 and Risk of Cardiovascular Diseases in Patients with Adult Growth Hormone DeficiencyXun Wu0Yunting Wang1Ziyu Ren2Linman Li3Wenjie Qian4Yue Chen5Wei Ren6Department of Endocrinology, The First Affiliated Hospital of Chongqing Medical University, Chongqing, ChinaDepartment of Endocrinology, The First Affiliated Hospital of Chongqing Medical University, Chongqing, ChinaDepartment of Endocrinology, The Second Affiliated Hospital of Chongqing Medical University, Chongqing, ChinaDepartment of Health Management Center, The First Affiliated Hospital of Chongqing Medical University, Chongqing, ChinaDepartment of Endocrinology, The First Affiliated Hospital of Chongqing Medical University, Chongqing, ChinaGeneral Practice, The 958 Hospital of the People’s Liberation Army, Chongqing, ChinaDepartment of Endocrinology, The First Affiliated Hospital of Chongqing Medical University, Chongqing, ChinaObjective. Patients with adult growth hormone deficiency (AGHD) confer a heightened risk of cardiovascular disease and increased mortality because of metabolic disorders. Growth differentiation factor-15 (GDF-15) plays an important role in predicting metabolic abnormalities. We sought to investigate the correlation between GDF-15 and cardiovascular risk in AGHD patients. Methods. The study enrolled 80 AGHD patients and 80 healthy subjects. We analyzed the association between GDF-15 and some major biochemical indicators. The potential association between GDF-15 and cardiovascular disease risk was analyzed. Results. The AGHD group exhibited increased waist-hip ratio and high-sensitivity C-reactive protein (hs-CRP) and lipid levels compared with the healthy control group. Serum GDF-15 levels in AGHD group were elevated significantly compared with the control group P<0.001. GDF-15 levels were negatively associated with insulin-like growth factor-1 in AGHD group P=0.006 and positively correlated with waist-to-hip ratio P=0.018, triglycerides P=0.007, and hs-CRP P=0.046. In addition, GDF-15 was positively correlated with Framingham risk score significantly after adjustment for other factors (r = 0.497, P<0.001). Moreover, GDF-15 was an independent risk factor for cardiovascular disease in AGHD patients after adjusting for traditional cardiovascular risk factors. Conclusion. Elevated GDF-15 levels were significantly associated with cardiovascular risk factors and can be considered as a predictive biomarker of cardiovascular risk in AGHD patients.http://dx.doi.org/10.1155/2021/5921863 |
| spellingShingle | Xun Wu Yunting Wang Ziyu Ren Linman Li Wenjie Qian Yue Chen Wei Ren Association between Growth Differentiation Factor-15 and Risk of Cardiovascular Diseases in Patients with Adult Growth Hormone Deficiency International Journal of Endocrinology |
| title | Association between Growth Differentiation Factor-15 and Risk of Cardiovascular Diseases in Patients with Adult Growth Hormone Deficiency |
| title_full | Association between Growth Differentiation Factor-15 and Risk of Cardiovascular Diseases in Patients with Adult Growth Hormone Deficiency |
| title_fullStr | Association between Growth Differentiation Factor-15 and Risk of Cardiovascular Diseases in Patients with Adult Growth Hormone Deficiency |
| title_full_unstemmed | Association between Growth Differentiation Factor-15 and Risk of Cardiovascular Diseases in Patients with Adult Growth Hormone Deficiency |
| title_short | Association between Growth Differentiation Factor-15 and Risk of Cardiovascular Diseases in Patients with Adult Growth Hormone Deficiency |
| title_sort | association between growth differentiation factor 15 and risk of cardiovascular diseases in patients with adult growth hormone deficiency |
| url | http://dx.doi.org/10.1155/2021/5921863 |
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