Molecular Characterization and Clinical Relevance of MGMT‐Silenced Pancreatic Cancer

Molecular Characterization and Clinical Relevance of MGMT‐Silenced Pancreatic Cancer

ABSTRACT Background The identification of actionable molecular targets of pancreatic cancer (PAC) is key to improving patient outcomes. We hypothesized O6‐methylguanine‐DNA methyltransferase (MGMT) silencing may occur in a subset of PAC tumors, with unexplored clinical and molecular correlates. Expe...

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Main Authors: Federico Nichetti, Marco Silvestri, Luca Agnelli, Andrea Franza, Chiara Pircher, Simone Rota, Paolo Ambrosini, Giuseppe Fotia, Jennifer Hüllein, Giovanni Randon, Panna Lajer, Federica Perrone, Elena Tamborini, Giuseppe Leoncini, Jorgelina Coppa, Michele Droz Dit Busset, Sara Pusceddu, Massimo Milione, Federica Morano, Filippo Pietrantonio, Giancarlo Pruneri, Vincenzo Mazzaferro, Daniel B. Lipka, Bruno Christian Köhler, Daniel Hübschmann, Stefan Fröhling, Filippo deBraud, Monica Niger
Format: Article
Language:English
Published: Wiley 2024-12-01
Series:Cancer Medicine
Subjects:
biomarker
KRAS wild type
MGMT
molecular profiling
pancreatic cancer
temozolomide
Online Access:https://doi.org/10.1002/cam4.70393
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