Bladder Cancer in HIV-infected Adults: An Emerging Issue? Case-Reports and Systematic Review.
<h4>Objectives</h4>Non-AIDS-related malignancies now represent a frequent cause of death among HIV-infected patients. Albeit bladder cancer is one of the most common malignancies worldwide, it has been rarely reported among HIV-infected patients. We wished to assess the prevalence and ch...
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| Format: | Article |
| Language: | English |
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Public Library of Science (PLoS)
2015-01-01
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| Series: | PLoS ONE |
| Online Access: | https://doi.org/10.1371/journal.pone.0144237 |
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| author | Sylvain Chawki Guillaume Ploussard Claire Montlahuc Jérome Verine Pierre Mongiat-Artus François Desgrandchamps Jean-Michel Molina |
| author_facet | Sylvain Chawki Guillaume Ploussard Claire Montlahuc Jérome Verine Pierre Mongiat-Artus François Desgrandchamps Jean-Michel Molina |
| author_sort | Sylvain Chawki |
| collection | DOAJ |
| description | <h4>Objectives</h4>Non-AIDS-related malignancies now represent a frequent cause of death among HIV-infected patients. Albeit bladder cancer is one of the most common malignancies worldwide, it has been rarely reported among HIV-infected patients. We wished to assess the prevalence and characteristics of bladder cancer in HIV-infected patients.<h4>Methods</h4>We conducted a single center retrospective study from 1998 to 2013 in a university hospital in Paris. Cases of bladder cancer among HIV-infected patients were identified using the electronic records of the hospital database and of the HIV-infected cohort. Patient characteristics and outcomes were retrieved from patients charts. A systematic review of published cases of bladder cancers in patients with HIV-infection was also performed.<h4>Results</h4>During the study period we identified 15 HIV-infected patients (0.2% of the cohort) with a bladder cancer. Patients were mostly men (73%) and smokers (67%), with a median age of 56 years at cancer diagnosis. Bladder cancer was diagnosed a median of 14 years after HIV-infection. Most patients were on ART (86%) with median current and nadir CD4 cell counts of 506 and 195 cells/mm3, respectively. Haematuria (73%) was the most frequent presenting symptom and HPV-associated lesions were seen in 6/10 (60%) patients. Histopathology showed transitional cell carcinoma in 80% and a high proportion of tumors with muscle invasion (47%) and high histologic grade (73%). One-year survival rate was 74.6%. The systematic review identified 13 additional cases of urothelial bladder cancers which shared similar features.<h4>Conclusions</h4>Bladder cancers in HIV-infected patients remain rare but may occur in relatively young patients with a low nadir CD4 cell count, have aggressive pathological features and can be fatal. |
| format | Article |
| id | doaj-art-3eb4719972714d7f8a0b272cef3dc31e |
| institution | Kabale University |
| issn | 1932-6203 |
| language | English |
| publishDate | 2015-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj-art-3eb4719972714d7f8a0b272cef3dc31e2025-08-20T03:49:59ZengPublic Library of Science (PLoS)PLoS ONE1932-62032015-01-011012e014423710.1371/journal.pone.0144237Bladder Cancer in HIV-infected Adults: An Emerging Issue? Case-Reports and Systematic Review.Sylvain ChawkiGuillaume PloussardClaire MontlahucJérome VerinePierre Mongiat-ArtusFrançois DesgrandchampsJean-Michel Molina<h4>Objectives</h4>Non-AIDS-related malignancies now represent a frequent cause of death among HIV-infected patients. Albeit bladder cancer is one of the most common malignancies worldwide, it has been rarely reported among HIV-infected patients. We wished to assess the prevalence and characteristics of bladder cancer in HIV-infected patients.<h4>Methods</h4>We conducted a single center retrospective study from 1998 to 2013 in a university hospital in Paris. Cases of bladder cancer among HIV-infected patients were identified using the electronic records of the hospital database and of the HIV-infected cohort. Patient characteristics and outcomes were retrieved from patients charts. A systematic review of published cases of bladder cancers in patients with HIV-infection was also performed.<h4>Results</h4>During the study period we identified 15 HIV-infected patients (0.2% of the cohort) with a bladder cancer. Patients were mostly men (73%) and smokers (67%), with a median age of 56 years at cancer diagnosis. Bladder cancer was diagnosed a median of 14 years after HIV-infection. Most patients were on ART (86%) with median current and nadir CD4 cell counts of 506 and 195 cells/mm3, respectively. Haematuria (73%) was the most frequent presenting symptom and HPV-associated lesions were seen in 6/10 (60%) patients. Histopathology showed transitional cell carcinoma in 80% and a high proportion of tumors with muscle invasion (47%) and high histologic grade (73%). One-year survival rate was 74.6%. The systematic review identified 13 additional cases of urothelial bladder cancers which shared similar features.<h4>Conclusions</h4>Bladder cancers in HIV-infected patients remain rare but may occur in relatively young patients with a low nadir CD4 cell count, have aggressive pathological features and can be fatal.https://doi.org/10.1371/journal.pone.0144237 |
| spellingShingle | Sylvain Chawki Guillaume Ploussard Claire Montlahuc Jérome Verine Pierre Mongiat-Artus François Desgrandchamps Jean-Michel Molina Bladder Cancer in HIV-infected Adults: An Emerging Issue? Case-Reports and Systematic Review. PLoS ONE |
| title | Bladder Cancer in HIV-infected Adults: An Emerging Issue? Case-Reports and Systematic Review. |
| title_full | Bladder Cancer in HIV-infected Adults: An Emerging Issue? Case-Reports and Systematic Review. |
| title_fullStr | Bladder Cancer in HIV-infected Adults: An Emerging Issue? Case-Reports and Systematic Review. |
| title_full_unstemmed | Bladder Cancer in HIV-infected Adults: An Emerging Issue? Case-Reports and Systematic Review. |
| title_short | Bladder Cancer in HIV-infected Adults: An Emerging Issue? Case-Reports and Systematic Review. |
| title_sort | bladder cancer in hiv infected adults an emerging issue case reports and systematic review |
| url | https://doi.org/10.1371/journal.pone.0144237 |
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