The Impact of Immunosenescence on Pulmonary Disease
The global population is aging with significant gains in life expectancy particularly in the developed world. Consequently, greater focus on understanding the processes that underlie physiological aging has occurred. Key facets of advancing age include genomic instability, telomere shortening, epige...
Saved in:
| Main Authors: | , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2015-01-01
|
| Series: | Mediators of Inflammation |
| Online Access: | http://dx.doi.org/10.1155/2015/692546 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1850216134471581696 |
|---|---|
| author | Michelle A. Murray Sanjay H. Chotirmall |
| author_facet | Michelle A. Murray Sanjay H. Chotirmall |
| author_sort | Michelle A. Murray |
| collection | DOAJ |
| description | The global population is aging with significant gains in life expectancy particularly in the developed world. Consequently, greater focus on understanding the processes that underlie physiological aging has occurred. Key facets of advancing age include genomic instability, telomere shortening, epigenetic changes, and declines in immune function termed immunosenescence. Immunosenescence and its associated chronic low grade systemic “inflamm-aging” contribute to the development and progression of pulmonary disease in older individuals. These physiological processes predispose to pulmonary infection and confer specific and unique clinical phenotypes observed in chronic respiratory disease including late-onset asthma, chronic obstructive pulmonary disease, and pulmonary fibrosis. Emerging concepts of the gut and airway microbiome further complicate the interrelationship between host and microorganism particularly from an immunological perspective and especially so in the setting of immunosenescence. This review focuses on our current understanding of the aging process, immunosenescence, and how it can potentially impact on various pulmonary diseases and the human microbiome. |
| format | Article |
| id | doaj-art-3eb27e7ee2b34bd087b1d8230652430c |
| institution | OA Journals |
| issn | 0962-9351 1466-1861 |
| language | English |
| publishDate | 2015-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Mediators of Inflammation |
| spelling | doaj-art-3eb27e7ee2b34bd087b1d8230652430c2025-08-20T02:08:24ZengWileyMediators of Inflammation0962-93511466-18612015-01-01201510.1155/2015/692546692546The Impact of Immunosenescence on Pulmonary DiseaseMichelle A. Murray0Sanjay H. Chotirmall1Department of Respiratory Medicine, Mater Misericordiae Hospital, Eccles Street, Dublin 7, IrelandLee Kong Chian School of Medicine, Nanyang Technological University, 308232, SingaporeThe global population is aging with significant gains in life expectancy particularly in the developed world. Consequently, greater focus on understanding the processes that underlie physiological aging has occurred. Key facets of advancing age include genomic instability, telomere shortening, epigenetic changes, and declines in immune function termed immunosenescence. Immunosenescence and its associated chronic low grade systemic “inflamm-aging” contribute to the development and progression of pulmonary disease in older individuals. These physiological processes predispose to pulmonary infection and confer specific and unique clinical phenotypes observed in chronic respiratory disease including late-onset asthma, chronic obstructive pulmonary disease, and pulmonary fibrosis. Emerging concepts of the gut and airway microbiome further complicate the interrelationship between host and microorganism particularly from an immunological perspective and especially so in the setting of immunosenescence. This review focuses on our current understanding of the aging process, immunosenescence, and how it can potentially impact on various pulmonary diseases and the human microbiome.http://dx.doi.org/10.1155/2015/692546 |
| spellingShingle | Michelle A. Murray Sanjay H. Chotirmall The Impact of Immunosenescence on Pulmonary Disease Mediators of Inflammation |
| title | The Impact of Immunosenescence on Pulmonary Disease |
| title_full | The Impact of Immunosenescence on Pulmonary Disease |
| title_fullStr | The Impact of Immunosenescence on Pulmonary Disease |
| title_full_unstemmed | The Impact of Immunosenescence on Pulmonary Disease |
| title_short | The Impact of Immunosenescence on Pulmonary Disease |
| title_sort | impact of immunosenescence on pulmonary disease |
| url | http://dx.doi.org/10.1155/2015/692546 |
| work_keys_str_mv | AT michelleamurray theimpactofimmunosenescenceonpulmonarydisease AT sanjayhchotirmall theimpactofimmunosenescenceonpulmonarydisease AT michelleamurray impactofimmunosenescenceonpulmonarydisease AT sanjayhchotirmall impactofimmunosenescenceonpulmonarydisease |