The correlation between serum alkaline phosphatase and grip strength in middle-aged and elderly people: NHANES 2011–2014
Abstract Background Serum alkaline phosphatase (ALP) plays a crucial role in bone and muscle health. Previous studies have demonstrated that serum alkaline phosphatase (ALP) is closely associated with muscle mass. Nevertheless, the association between serum alkaline phosphatase (ALP) and grip streng...
Saved in:
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
BMC
2025-02-01
|
| Series: | BMC Musculoskeletal Disorders |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s12891-025-08408-2 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1850186479398027264 |
|---|---|
| author | Ziyi Zhang Jiajie Zhou Anpei Ma Honggu Chen Bo Wang Guoyang Zhao |
| author_facet | Ziyi Zhang Jiajie Zhou Anpei Ma Honggu Chen Bo Wang Guoyang Zhao |
| author_sort | Ziyi Zhang |
| collection | DOAJ |
| description | Abstract Background Serum alkaline phosphatase (ALP) plays a crucial role in bone and muscle health. Previous studies have demonstrated that serum alkaline phosphatase (ALP) is closely associated with muscle mass. Nevertheless, the association between serum alkaline phosphatase (ALP) and grip strength remains unclear. Therefore, the present study focused on exploring the association of serum ALP with grip strength in middle-aged and elderly people. Methods We conducted a cross-sectional study using data from the National Health and Nutrition Examination Survey conducted from 2011 to 2014. A total of 3514 participants (1891 males and 1623 females) aged 40–80 years were included in this study. Serum ALP and pelvic grip strength were analyzed as independent and dependent variables, additional variables were the possible impact modifiers. weighted generalized linear models and stratified analysis by gender, age group, and race were applied to assess the relationship between serum ALP and grip strength. Smooth curve fitting and threshold effect analysis/saturation effect analysis were used to analyze the nonlinear relationship between the 2 variables. Results In the gender-stratified subgroup analysis, we observed an inverse association between serum ALP and grip strength in both male and female. When stratified by age group, the association remained significant among participants 40–59 years of age, but not among those ≥ 60 years old. When stratified by race, the association remained significant among Non-Hispanic White and Non-Hispanic Black. It is noteworthy that serum ALP and grip strength showed a significant negative correlation among female aged 40–59 years, but not among female aged ≥ 60 years. Additionally, Smooth curve fitting showed that serum ALP had a nonlinear relationship with grip strength in male aged 40–59 years and male aged over 60 years, the inflection points are 54 IU and 97 IU respectively. Conclusion Our study revealed an inverse relationship between serum ALP and grip strength, this finding offers new insights and avenues for understanding how serum alkaline phosphatase affects skeletal muscle health. |
| format | Article |
| id | doaj-art-3eb1772e5d8f4c4bbf2a915f5012912c |
| institution | OA Journals |
| issn | 1471-2474 |
| language | English |
| publishDate | 2025-02-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Musculoskeletal Disorders |
| spelling | doaj-art-3eb1772e5d8f4c4bbf2a915f5012912c2025-08-20T02:16:21ZengBMCBMC Musculoskeletal Disorders1471-24742025-02-0126111010.1186/s12891-025-08408-2The correlation between serum alkaline phosphatase and grip strength in middle-aged and elderly people: NHANES 2011–2014Ziyi Zhang0Jiajie Zhou1Anpei Ma2Honggu Chen3Bo Wang4Guoyang Zhao5Affiliated Hospital of Jiangsu UniversityAffiliated Hospital of Jiangsu UniversityYancheng First People’s HospitalZhejiang Taizhou HospitalAffiliated Hospital of Jiangsu UniversityAffiliated Hospital of Jiangsu UniversityAbstract Background Serum alkaline phosphatase (ALP) plays a crucial role in bone and muscle health. Previous studies have demonstrated that serum alkaline phosphatase (ALP) is closely associated with muscle mass. Nevertheless, the association between serum alkaline phosphatase (ALP) and grip strength remains unclear. Therefore, the present study focused on exploring the association of serum ALP with grip strength in middle-aged and elderly people. Methods We conducted a cross-sectional study using data from the National Health and Nutrition Examination Survey conducted from 2011 to 2014. A total of 3514 participants (1891 males and 1623 females) aged 40–80 years were included in this study. Serum ALP and pelvic grip strength were analyzed as independent and dependent variables, additional variables were the possible impact modifiers. weighted generalized linear models and stratified analysis by gender, age group, and race were applied to assess the relationship between serum ALP and grip strength. Smooth curve fitting and threshold effect analysis/saturation effect analysis were used to analyze the nonlinear relationship between the 2 variables. Results In the gender-stratified subgroup analysis, we observed an inverse association between serum ALP and grip strength in both male and female. When stratified by age group, the association remained significant among participants 40–59 years of age, but not among those ≥ 60 years old. When stratified by race, the association remained significant among Non-Hispanic White and Non-Hispanic Black. It is noteworthy that serum ALP and grip strength showed a significant negative correlation among female aged 40–59 years, but not among female aged ≥ 60 years. Additionally, Smooth curve fitting showed that serum ALP had a nonlinear relationship with grip strength in male aged 40–59 years and male aged over 60 years, the inflection points are 54 IU and 97 IU respectively. Conclusion Our study revealed an inverse relationship between serum ALP and grip strength, this finding offers new insights and avenues for understanding how serum alkaline phosphatase affects skeletal muscle health.https://doi.org/10.1186/s12891-025-08408-2Serum alkaline phosphataseGrip strengthSarcopeniaNHANES |
| spellingShingle | Ziyi Zhang Jiajie Zhou Anpei Ma Honggu Chen Bo Wang Guoyang Zhao The correlation between serum alkaline phosphatase and grip strength in middle-aged and elderly people: NHANES 2011–2014 BMC Musculoskeletal Disorders Serum alkaline phosphatase Grip strength Sarcopenia NHANES |
| title | The correlation between serum alkaline phosphatase and grip strength in middle-aged and elderly people: NHANES 2011–2014 |
| title_full | The correlation between serum alkaline phosphatase and grip strength in middle-aged and elderly people: NHANES 2011–2014 |
| title_fullStr | The correlation between serum alkaline phosphatase and grip strength in middle-aged and elderly people: NHANES 2011–2014 |
| title_full_unstemmed | The correlation between serum alkaline phosphatase and grip strength in middle-aged and elderly people: NHANES 2011–2014 |
| title_short | The correlation between serum alkaline phosphatase and grip strength in middle-aged and elderly people: NHANES 2011–2014 |
| title_sort | correlation between serum alkaline phosphatase and grip strength in middle aged and elderly people nhanes 2011 2014 |
| topic | Serum alkaline phosphatase Grip strength Sarcopenia NHANES |
| url | https://doi.org/10.1186/s12891-025-08408-2 |
| work_keys_str_mv | AT ziyizhang thecorrelationbetweenserumalkalinephosphataseandgripstrengthinmiddleagedandelderlypeoplenhanes20112014 AT jiajiezhou thecorrelationbetweenserumalkalinephosphataseandgripstrengthinmiddleagedandelderlypeoplenhanes20112014 AT anpeima thecorrelationbetweenserumalkalinephosphataseandgripstrengthinmiddleagedandelderlypeoplenhanes20112014 AT hongguchen thecorrelationbetweenserumalkalinephosphataseandgripstrengthinmiddleagedandelderlypeoplenhanes20112014 AT bowang thecorrelationbetweenserumalkalinephosphataseandgripstrengthinmiddleagedandelderlypeoplenhanes20112014 AT guoyangzhao thecorrelationbetweenserumalkalinephosphataseandgripstrengthinmiddleagedandelderlypeoplenhanes20112014 AT ziyizhang correlationbetweenserumalkalinephosphataseandgripstrengthinmiddleagedandelderlypeoplenhanes20112014 AT jiajiezhou correlationbetweenserumalkalinephosphataseandgripstrengthinmiddleagedandelderlypeoplenhanes20112014 AT anpeima correlationbetweenserumalkalinephosphataseandgripstrengthinmiddleagedandelderlypeoplenhanes20112014 AT hongguchen correlationbetweenserumalkalinephosphataseandgripstrengthinmiddleagedandelderlypeoplenhanes20112014 AT bowang correlationbetweenserumalkalinephosphataseandgripstrengthinmiddleagedandelderlypeoplenhanes20112014 AT guoyangzhao correlationbetweenserumalkalinephosphataseandgripstrengthinmiddleagedandelderlypeoplenhanes20112014 |