Unexpected discovery of hepatic cancer via 68Ga-PSMA PET/CT in the staging of prostate cancer
PSMA PET/CT (prostate-specific membrane antigen-based positron emission tomography) measures the overexpression of PSMA with the highest sensitivity in prostate cancer, offering a feasible pathway for detecting primary tumors, metastasis, and recurrences. Several cases reported a PSMA uptake in othe...
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| Format: | Article |
| Language: | English |
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Elsevier
2025-06-01
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| Series: | Current Problems in Cancer: Case Reports |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2666621925000298 |
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| author | Radu Alexa Jennifer Kranz Marco Hoffmann Alexandra Barabasch Sophie Leypold Felix M. Mottaghy Matthias Saar |
| author_facet | Radu Alexa Jennifer Kranz Marco Hoffmann Alexandra Barabasch Sophie Leypold Felix M. Mottaghy Matthias Saar |
| author_sort | Radu Alexa |
| collection | DOAJ |
| description | PSMA PET/CT (prostate-specific membrane antigen-based positron emission tomography) measures the overexpression of PSMA with the highest sensitivity in prostate cancer, offering a feasible pathway for detecting primary tumors, metastasis, and recurrences. Several cases reported a PSMA uptake in other solid tumors including also cholangiocarcinoma, broadening its potential utility. Thus, PSMA PET/CT's primary value lies in enhancing prostate cancer diagnostics, but it also aids in detecting other malignancies. Here, we present the case report of an 82-year-old man initially diagnosed with high-risk prostate cancer with unusual PSMA accumulation in the liver at PSMA PET/CT, later identified as a cholangiocarcinoma. |
| format | Article |
| id | doaj-art-3eb0a7b63b79448e942b0e83069265b3 |
| institution | OA Journals |
| issn | 2666-6219 |
| language | English |
| publishDate | 2025-06-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Current Problems in Cancer: Case Reports |
| spelling | doaj-art-3eb0a7b63b79448e942b0e83069265b32025-08-20T02:05:17ZengElsevierCurrent Problems in Cancer: Case Reports2666-62192025-06-011810037710.1016/j.cpccr.2025.100377Unexpected discovery of hepatic cancer via 68Ga-PSMA PET/CT in the staging of prostate cancerRadu Alexa0Jennifer Kranz1Marco Hoffmann2Alexandra Barabasch3Sophie Leypold4Felix M. Mottaghy5Matthias Saar6Department of Urology and Pediatric Urology University Hospital, RWTH Aachen University, Aachen, Germany; Center for Integrated Oncology Aachen Bonn Cologne Düsseldorf (CIO ABCD), Aachen, Germany; Corresponding author at: Department of Urology and Pediatric Urology, RWTH Aachen University, Pauwelsstr. 30, Aachen, 52057, Germany.Department of Urology and Pediatric Urology University Hospital, RWTH Aachen University, Aachen, Germany; Center for Integrated Oncology Aachen Bonn Cologne Düsseldorf (CIO ABCD), Aachen, Germany; Department of Urology and Kidney Transplantation, Martin Luther University, Halle (Saale), GermanyDepartment of Urology and Pediatric Urology University Hospital, RWTH Aachen University, Aachen, Germany; Center for Integrated Oncology Aachen Bonn Cologne Düsseldorf (CIO ABCD), Aachen, GermanyDepartment of Radiology, RWTH Aachen University, Aachen, GermanyDepartment of Pathology, RWTH Aachen University, Aachen, GermanyDepartment of Nuclear Medicine, RWTH Aachen University, Aachen, Germany and Department of Radiology and Nuclear Medicine, Maastricht University Medical Center (MUMC+), Maastricht, the NetherlandsDepartment of Urology and Pediatric Urology University Hospital, RWTH Aachen University, Aachen, Germany; Center for Integrated Oncology Aachen Bonn Cologne Düsseldorf (CIO ABCD), Aachen, GermanyPSMA PET/CT (prostate-specific membrane antigen-based positron emission tomography) measures the overexpression of PSMA with the highest sensitivity in prostate cancer, offering a feasible pathway for detecting primary tumors, metastasis, and recurrences. Several cases reported a PSMA uptake in other solid tumors including also cholangiocarcinoma, broadening its potential utility. Thus, PSMA PET/CT's primary value lies in enhancing prostate cancer diagnostics, but it also aids in detecting other malignancies. Here, we present the case report of an 82-year-old man initially diagnosed with high-risk prostate cancer with unusual PSMA accumulation in the liver at PSMA PET/CT, later identified as a cholangiocarcinoma.http://www.sciencedirect.com/science/article/pii/S2666621925000298Prostate cancerCholangiocarcinoma68ga-psma pet/ct |
| spellingShingle | Radu Alexa Jennifer Kranz Marco Hoffmann Alexandra Barabasch Sophie Leypold Felix M. Mottaghy Matthias Saar Unexpected discovery of hepatic cancer via 68Ga-PSMA PET/CT in the staging of prostate cancer Current Problems in Cancer: Case Reports Prostate cancer Cholangiocarcinoma 68ga-psma pet/ct |
| title | Unexpected discovery of hepatic cancer via 68Ga-PSMA PET/CT in the staging of prostate cancer |
| title_full | Unexpected discovery of hepatic cancer via 68Ga-PSMA PET/CT in the staging of prostate cancer |
| title_fullStr | Unexpected discovery of hepatic cancer via 68Ga-PSMA PET/CT in the staging of prostate cancer |
| title_full_unstemmed | Unexpected discovery of hepatic cancer via 68Ga-PSMA PET/CT in the staging of prostate cancer |
| title_short | Unexpected discovery of hepatic cancer via 68Ga-PSMA PET/CT in the staging of prostate cancer |
| title_sort | unexpected discovery of hepatic cancer via 68ga psma pet ct in the staging of prostate cancer |
| topic | Prostate cancer Cholangiocarcinoma 68ga-psma pet/ct |
| url | http://www.sciencedirect.com/science/article/pii/S2666621925000298 |
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