Unexpected discovery of hepatic cancer via 68Ga-PSMA PET/CT in the staging of prostate cancer

Unexpected discovery of hepatic cancer via 68Ga-PSMA PET/CT in the staging of prostate cancer

PSMA PET/CT (prostate-specific membrane antigen-based positron emission tomography) measures the overexpression of PSMA with the highest sensitivity in prostate cancer, offering a feasible pathway for detecting primary tumors, metastasis, and recurrences. Several cases reported a PSMA uptake in othe...

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Bibliographic Details
Main Authors: Radu Alexa, Jennifer Kranz, Marco Hoffmann, Alexandra Barabasch, Sophie Leypold, Felix M. Mottaghy, Matthias Saar
Format: Article
Language:English
Published: Elsevier 2025-06-01
Series:Current Problems in Cancer: Case Reports
Subjects:
Prostate cancer
Cholangiocarcinoma
68ga-psma pet/ct
Online Access:http://www.sciencedirect.com/science/article/pii/S2666621925000298
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Summary:PSMA PET/CT (prostate-specific membrane antigen-based positron emission tomography) measures the overexpression of PSMA with the highest sensitivity in prostate cancer, offering a feasible pathway for detecting primary tumors, metastasis, and recurrences. Several cases reported a PSMA uptake in other solid tumors including also cholangiocarcinoma, broadening its potential utility. Thus, PSMA PET/CT's primary value lies in enhancing prostate cancer diagnostics, but it also aids in detecting other malignancies. Here, we present the case report of an 82-year-old man initially diagnosed with high-risk prostate cancer with unusual PSMA accumulation in the liver at PSMA PET/CT, later identified as a cholangiocarcinoma.
ISSN:2666-6219

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