Performance of ChatGPT-4o and Four Open-Source Large Language Models in Generating Diagnoses Based on China’s Rare Disease Catalog: Comparative Study

Performance of ChatGPT-4o and Four Open-Source Large Language Models in Generating Diagnoses Based on China’s Rare Disease Catalog: Comparative Study

Abstract BackgroundDiagnosing rare diseases remains challenging due to their inherent complexity and limited physician knowledge. Large language models (LLMs) offer new potential to enhance diagnostic workflows. ObjectiveThis study aimed to evaluate the diagnostic...

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Main Authors: Wei Zhong, YiFan Liu, Yan Liu, Kai Yang, HuiMin Gao, HuiHui Yan, WenJing Hao, YouSheng Yan, ChengHong Yin
Format: Article
Language:English
Published: JMIR Publications 2025-06-01
Series:Journal of Medical Internet Research
Online Access:https://www.jmir.org/2025/1/e69929
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