Interferon-α and thymosin-α1 plus tislelizumab enhance CD8+ T cell cytotoxicity toward pancreatic ductal adenocarcinoma

Interferon-α and thymosin-α1 plus tislelizumab enhance CD8+ T cell cytotoxicity toward pancreatic ductal adenocarcinoma

Summary: The strong immunosuppression and immune evasion of pancreatic ductal adenocarcinoma (PDAC) result in poor efficacy of immune checkpoint blockade. In this study, the PD-1 level on CD8+ T cells in the peripheral blood of patients with PDAC was significantly greater than that in the peripheral...

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Bibliographic Details
Main Authors: Shun Deng, Rilin Deng, Jinfeng Wang, Qi Hu, Biaoming Xu, Jinhai Zheng, Mingjing Peng, Wenzhi Tan, Haizhen Zhu, Chaohui Zuo
Format: Article
Language:English
Published: Elsevier 2025-08-01
Series:iScience
Subjects:
Immunology
cancer
Online Access:http://www.sciencedirect.com/science/article/pii/S2589004225013148
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