Impact of immunosuppressants on tumor pulmonary metastasis: new insight into transplantation for hepatocellular carcinoma
Pulmonary metastasis is a life-threatening complication for patients with hepatocellular carcinoma (HCC) undergoing liver transplantation (LT). In addition to the common mechanisms underlying tumor metastasis, another inevitable factor is that the application of immunosuppressive agents, including c...
Saved in:
| Main Authors: | , , , , , , , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
China Anti-Cancer Association
2024-11-01
|
| Series: | Cancer Biology & Medicine |
| Subjects: | |
| Online Access: | https://www.cancerbiomed.org/content/21/11/1033 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1850243405115817984 |
|---|---|
| author | Jinyan Chen Huigang Li Jianyong Zhuo Zuyuan Lin Zhihang Hu Chiyu He Xiang Wu Yiru Jin Zhanyi Lin Renyi Su Yiyang Sun Rongsen Wang Jiancai Sun Xuyong Wei Shusen Zheng Di Lu Xiao Xu |
| author_facet | Jinyan Chen Huigang Li Jianyong Zhuo Zuyuan Lin Zhihang Hu Chiyu He Xiang Wu Yiru Jin Zhanyi Lin Renyi Su Yiyang Sun Rongsen Wang Jiancai Sun Xuyong Wei Shusen Zheng Di Lu Xiao Xu |
| author_sort | Jinyan Chen |
| collection | DOAJ |
| description | Pulmonary metastasis is a life-threatening complication for patients with hepatocellular carcinoma (HCC) undergoing liver transplantation (LT). In addition to the common mechanisms underlying tumor metastasis, another inevitable factor is that the application of immunosuppressive agents, including calcineurin inhibitors (CNIs) and rapamycin inhibitors (mTORis), after transplantation could influence tumor recurrence and metastasis. In recent years, several studies have reported that mTORis, unlike CNIs, have the capacity to modulate the tumorigenic landscape post-liver transplantation by targeting metastasis-initiating cells and reshaping the pulmonary microenvironment. Therefore, we focused on the effects of immunosuppressive agents on the lung metastatic microenvironment and how mTORis impact tumor growth in distant organs. This revelation has provided profound insights into transplant oncology, leading to a renewed understanding of the use of immunosuppressants after LT for HCC. |
| format | Article |
| id | doaj-art-3eaa08ebf5f9437188a06cd2705f911c |
| institution | OA Journals |
| issn | 2095-3941 |
| language | English |
| publishDate | 2024-11-01 |
| publisher | China Anti-Cancer Association |
| record_format | Article |
| series | Cancer Biology & Medicine |
| spelling | doaj-art-3eaa08ebf5f9437188a06cd2705f911c2025-08-20T02:00:00ZengChina Anti-Cancer AssociationCancer Biology & Medicine2095-39412024-11-0121111033104910.20892/j.issn.2095-3941.2024.0267Impact of immunosuppressants on tumor pulmonary metastasis: new insight into transplantation for hepatocellular carcinomaJinyan Chen0Huigang Li1Jianyong Zhuo2Zuyuan Lin3Zhihang Hu4Chiyu He5Xiang Wu6Yiru Jin7Zhanyi Lin8Renyi Su9Yiyang Sun10Rongsen Wang11Jiancai Sun12Xuyong Wei13Shusen Zheng14Di Lu15Xiao Xu16Zhejiang University School of Medicine, Hangzhou 310058, ChinaZhejiang University School of Medicine, Hangzhou 310058, ChinaDepartment of Hepatobiliary and Pancreatic Surgery, Hangzhou First People’s Hospital, Hangzhou 310006, ChinaSchool of Basic Medical Sciences and Forensic Medicine, Hangzhou Medical College, Hangzhou 310053, ChinaZhejiang University School of Medicine, Hangzhou 310058, ChinaZhejiang University School of Medicine, Hangzhou 310058, ChinaZhejiang University School of Medicine, Hangzhou 310058, ChinaZhejiang University School of Medicine, Hangzhou 310058, ChinaZhejiang University School of Medicine, Hangzhou 310058, ChinaZhejiang University School of Medicine, Hangzhou 310058, ChinaThe Fourth School of Clinical Medicine, Zhejiang Chinese Medical University, Hangzhou 310063, ChinaSchool of Basic Medical Sciences and Forensic Medicine, Hangzhou Medical College, Hangzhou 310053, ChinaZhejiang University School of Medicine, Hangzhou 310058, ChinaDepartment of Hepatobiliary and Pancreatic Surgery, Hangzhou First People’s Hospital, Hangzhou 310006, ChinaDepartment of Hepatobiliary and Pancreatic Surgery, Shulan (Hangzhou) Hospital, Hangzhou 310022, ChinaDepartment of Hepatobiliary & Pancreatic Surgery and Minimally Invasive Surgery, Zhejiang Provincial People’s Hospital (Affiliated People’s Hospital), School of Clinical Medicine, Hangzhou Medical College, Hangzhou 310014, ChinaDepartment of Hepatobiliary & Pancreatic Surgery and Minimally Invasive Surgery, Zhejiang Provincial People’s Hospital (Affiliated People’s Hospital), School of Clinical Medicine, Hangzhou Medical College, Hangzhou 310014, ChinaPulmonary metastasis is a life-threatening complication for patients with hepatocellular carcinoma (HCC) undergoing liver transplantation (LT). In addition to the common mechanisms underlying tumor metastasis, another inevitable factor is that the application of immunosuppressive agents, including calcineurin inhibitors (CNIs) and rapamycin inhibitors (mTORis), after transplantation could influence tumor recurrence and metastasis. In recent years, several studies have reported that mTORis, unlike CNIs, have the capacity to modulate the tumorigenic landscape post-liver transplantation by targeting metastasis-initiating cells and reshaping the pulmonary microenvironment. Therefore, we focused on the effects of immunosuppressive agents on the lung metastatic microenvironment and how mTORis impact tumor growth in distant organs. This revelation has provided profound insights into transplant oncology, leading to a renewed understanding of the use of immunosuppressants after LT for HCC.https://www.cancerbiomed.org/content/21/11/1033liver transplantationhepatocellular carcinomalung immune microenvironmentlung metastasisimmunosuppressants |
| spellingShingle | Jinyan Chen Huigang Li Jianyong Zhuo Zuyuan Lin Zhihang Hu Chiyu He Xiang Wu Yiru Jin Zhanyi Lin Renyi Su Yiyang Sun Rongsen Wang Jiancai Sun Xuyong Wei Shusen Zheng Di Lu Xiao Xu Impact of immunosuppressants on tumor pulmonary metastasis: new insight into transplantation for hepatocellular carcinoma Cancer Biology & Medicine liver transplantation hepatocellular carcinoma lung immune microenvironment lung metastasis immunosuppressants |
| title | Impact of immunosuppressants on tumor pulmonary metastasis: new insight into transplantation for hepatocellular carcinoma |
| title_full | Impact of immunosuppressants on tumor pulmonary metastasis: new insight into transplantation for hepatocellular carcinoma |
| title_fullStr | Impact of immunosuppressants on tumor pulmonary metastasis: new insight into transplantation for hepatocellular carcinoma |
| title_full_unstemmed | Impact of immunosuppressants on tumor pulmonary metastasis: new insight into transplantation for hepatocellular carcinoma |
| title_short | Impact of immunosuppressants on tumor pulmonary metastasis: new insight into transplantation for hepatocellular carcinoma |
| title_sort | impact of immunosuppressants on tumor pulmonary metastasis new insight into transplantation for hepatocellular carcinoma |
| topic | liver transplantation hepatocellular carcinoma lung immune microenvironment lung metastasis immunosuppressants |
| url | https://www.cancerbiomed.org/content/21/11/1033 |
| work_keys_str_mv | AT jinyanchen impactofimmunosuppressantsontumorpulmonarymetastasisnewinsightintotransplantationforhepatocellularcarcinoma AT huigangli impactofimmunosuppressantsontumorpulmonarymetastasisnewinsightintotransplantationforhepatocellularcarcinoma AT jianyongzhuo impactofimmunosuppressantsontumorpulmonarymetastasisnewinsightintotransplantationforhepatocellularcarcinoma AT zuyuanlin impactofimmunosuppressantsontumorpulmonarymetastasisnewinsightintotransplantationforhepatocellularcarcinoma AT zhihanghu impactofimmunosuppressantsontumorpulmonarymetastasisnewinsightintotransplantationforhepatocellularcarcinoma AT chiyuhe impactofimmunosuppressantsontumorpulmonarymetastasisnewinsightintotransplantationforhepatocellularcarcinoma AT xiangwu impactofimmunosuppressantsontumorpulmonarymetastasisnewinsightintotransplantationforhepatocellularcarcinoma AT yirujin impactofimmunosuppressantsontumorpulmonarymetastasisnewinsightintotransplantationforhepatocellularcarcinoma AT zhanyilin impactofimmunosuppressantsontumorpulmonarymetastasisnewinsightintotransplantationforhepatocellularcarcinoma AT renyisu impactofimmunosuppressantsontumorpulmonarymetastasisnewinsightintotransplantationforhepatocellularcarcinoma AT yiyangsun impactofimmunosuppressantsontumorpulmonarymetastasisnewinsightintotransplantationforhepatocellularcarcinoma AT rongsenwang impactofimmunosuppressantsontumorpulmonarymetastasisnewinsightintotransplantationforhepatocellularcarcinoma AT jiancaisun impactofimmunosuppressantsontumorpulmonarymetastasisnewinsightintotransplantationforhepatocellularcarcinoma AT xuyongwei impactofimmunosuppressantsontumorpulmonarymetastasisnewinsightintotransplantationforhepatocellularcarcinoma AT shusenzheng impactofimmunosuppressantsontumorpulmonarymetastasisnewinsightintotransplantationforhepatocellularcarcinoma AT dilu impactofimmunosuppressantsontumorpulmonarymetastasisnewinsightintotransplantationforhepatocellularcarcinoma AT xiaoxu impactofimmunosuppressantsontumorpulmonarymetastasisnewinsightintotransplantationforhepatocellularcarcinoma |