Research advances in the effect of cancer-associated fibroblasts on the biological behavior and treatment of malignant tumors
Tumor microenvironment (TME) plays an important role in the structure and function of malignant tumor stroma. Cancer-associated fibroblasts (CAFs) have a strong ability of extracellular matrix synthesis and microenvironment remodeling, which can affect the development and progression of tumors. CAFs...
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| Format: | Article |
| Language: | zho |
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Editorial Office of Journal of Precision Medicine
2025-06-01
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| Series: | 精准医学杂志 |
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| Online Access: | https://jpmed.qdu.edu.cn/fileup/2096-529X/PDF/1750385789308-205866404.pdf |
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| _version_ | 1850115990459777024 |
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| author | YUN Jie, BIAN Chao, LI Zhijun |
| author_facet | YUN Jie, BIAN Chao, LI Zhijun |
| author_sort | YUN Jie, BIAN Chao, LI Zhijun |
| collection | DOAJ |
| description | Tumor microenvironment (TME) plays an important role in the structure and function of malignant tumor stroma. Cancer-associated fibroblasts (CAFs) have a strong ability of extracellular matrix synthesis and microenvironment remodeling, which can affect the development and progression of tumors. CAFs can produce the subgroups with different functions in different types of TME, and the study of CAF subgroups has a guiding significance for tumor therapy. This article reviews the effect of CAFs and its subgroups on the biological behavior and treatment of malignant tumors, in order to provide a reference for the clinical treatment of malignant tumors. |
| format | Article |
| id | doaj-art-3ea429a48c974ce5ad0880b674e34d7a |
| institution | OA Journals |
| issn | 2096-529X |
| language | zho |
| publishDate | 2025-06-01 |
| publisher | Editorial Office of Journal of Precision Medicine |
| record_format | Article |
| series | 精准医学杂志 |
| spelling | doaj-art-3ea429a48c974ce5ad0880b674e34d7a2025-08-20T02:36:27ZzhoEditorial Office of Journal of Precision Medicine精准医学杂志2096-529X2025-06-0140327928210.13362/j.jpmed.202540031Research advances in the effect of cancer-associated fibroblasts on the biological behavior and treatment of malignant tumorsYUN Jie, BIAN Chao, LI Zhijun0Inner Mongolia Clinical College, Inner Mongolia Medical University, Hohhot 010010, ChinaTumor microenvironment (TME) plays an important role in the structure and function of malignant tumor stroma. Cancer-associated fibroblasts (CAFs) have a strong ability of extracellular matrix synthesis and microenvironment remodeling, which can affect the development and progression of tumors. CAFs can produce the subgroups with different functions in different types of TME, and the study of CAF subgroups has a guiding significance for tumor therapy. This article reviews the effect of CAFs and its subgroups on the biological behavior and treatment of malignant tumors, in order to provide a reference for the clinical treatment of malignant tumors.https://jpmed.qdu.edu.cn/fileup/2096-529X/PDF/1750385789308-205866404.pdfcancer-associated fibroblasts|tumor microenvironment|extracellular matrix|molecular targeted therapy|review |
| spellingShingle | YUN Jie, BIAN Chao, LI Zhijun Research advances in the effect of cancer-associated fibroblasts on the biological behavior and treatment of malignant tumors 精准医学杂志 cancer-associated fibroblasts|tumor microenvironment|extracellular matrix|molecular targeted therapy|review |
| title | Research advances in the effect of cancer-associated fibroblasts on the biological behavior and treatment of malignant tumors |
| title_full | Research advances in the effect of cancer-associated fibroblasts on the biological behavior and treatment of malignant tumors |
| title_fullStr | Research advances in the effect of cancer-associated fibroblasts on the biological behavior and treatment of malignant tumors |
| title_full_unstemmed | Research advances in the effect of cancer-associated fibroblasts on the biological behavior and treatment of malignant tumors |
| title_short | Research advances in the effect of cancer-associated fibroblasts on the biological behavior and treatment of malignant tumors |
| title_sort | research advances in the effect of cancer associated fibroblasts on the biological behavior and treatment of malignant tumors |
| topic | cancer-associated fibroblasts|tumor microenvironment|extracellular matrix|molecular targeted therapy|review |
| url | https://jpmed.qdu.edu.cn/fileup/2096-529X/PDF/1750385789308-205866404.pdf |
| work_keys_str_mv | AT yunjiebianchaolizhijun researchadvancesintheeffectofcancerassociatedfibroblastsonthebiologicalbehaviorandtreatmentofmalignanttumors |