Loss of stimulator of interferon genes (STING) promotes accumulation of cholesterol and triglycerides throughout life in mice

Loss of stimulator of interferon genes (STING) promotes accumulation of cholesterol and triglycerides throughout life in mice

Abstract Background The Stimulator of Interferon Genes (STING) pathway is pivotal in innate immunity, facilitating the detection of cytosolic DNA and initiating type I interferon-dependent responses. In addition to its immunological roles, STING has been increasingly associated with metabolic regula...

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Bibliographic Details
Main Authors: Ian Riquelme, Daniela Carrillanca, Camila Sánchez-Pérez, Andrea Monterroza, Bairon Hernández-Rojas, Gonzalo Riadi, Gonzalo I. Cancino, Paola Murgas
Format: Article
Language:English
Published: BMC 2025-07-01
Series:Biological Research
Subjects:
STING
Lipid metabolism
Triglycerides
Cholesterol
Aging
Adipose tissue
Online Access:https://doi.org/10.1186/s40659-025-00624-3
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