CHROMOPHOBE HEPATOCELLULAR CARCINOMA: DIAGNOSTIC CHALLENGES
ABSTRACT BACKGROUND: Hepatocellular carcinoma (HCC) encompasses rare variants like chromophobe hepatocellular carcinoma (CHCC) characterized by distinct histological features and molecular profiles. CASE REPORT: A 56-year-old male with chronic hepatitis C, presenting pain in the right hypochondriu...
Saved in:
| Main Authors: | , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Colégio Brasileiro de Cirurgia Digestiva
2025-01-01
|
| Series: | ABCD: Arquivos Brasileiros de Cirurgia Digestiva |
| Subjects: | |
| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0102-67202024000100337&lng=en&tlng=en |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832592450794815488 |
|---|---|
| author | Sana Ben-Slama Ines Mallek Eya Ghorbeli Mohamed Hajri Taher Labidi Hafedh Mestiri Ahlem Lahmar Dhouha Bacha |
| author_facet | Sana Ben-Slama Ines Mallek Eya Ghorbeli Mohamed Hajri Taher Labidi Hafedh Mestiri Ahlem Lahmar Dhouha Bacha |
| author_sort | Sana Ben-Slama |
| collection | DOAJ |
| description | ABSTRACT BACKGROUND: Hepatocellular carcinoma (HCC) encompasses rare variants like chromophobe hepatocellular carcinoma (CHCC) characterized by distinct histological features and molecular profiles. CASE REPORT: A 56-year-old male with chronic hepatitis C, presenting pain in the right hypochondrium. Imaging revealed a solitary liver lesion, subsequently resected and histologically diagnosed as HCC. Macroscopic examination found a 4×4 cm encapsulated liver nodule with necrotic areas, surrounded by numerous smaller satellite nodules in Segment 6. The liver was in micronodular cirrhosis. Histologically, the tumor had focal trabecular or pseudoglandular patterns within a vascularized stroma. The cells were large, with clear to eosinophilic cytoplasm and hyperchromatic and pleomorphic nuclei with focal anaplastic features. No vascular invasion was noted in adjacent cirrhotic liver tissue. RESULTS: The final diagnosis was CHCC. Due to its rarity and overlapping characteristics with other hepatic tumors, CHCC poses diagnostic challenges. Accurate diagnosis necessitates thorough histopathological assessment and molecular testing. The identification of the alternative lengthening of telomeres phenotype may distinguish CHCC from conventional HCC and hold potential implications for targeted therapeutic approaches. CONCLUSIONS: Recognition of HCC variants is critical for effective management and underscores the need for continued research into its clinical behavior and therapeutic responses. |
| format | Article |
| id | doaj-art-3ea265a90c834bf5b84cef27a238cd09 |
| institution | Kabale University |
| issn | 0102-6720 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Colégio Brasileiro de Cirurgia Digestiva |
| record_format | Article |
| series | ABCD: Arquivos Brasileiros de Cirurgia Digestiva |
| spelling | doaj-art-3ea265a90c834bf5b84cef27a238cd092025-01-21T07:43:20ZengColégio Brasileiro de Cirurgia DigestivaABCD: Arquivos Brasileiros de Cirurgia Digestiva0102-67202025-01-013710.1590/0102-6720202400069e1863CHROMOPHOBE HEPATOCELLULAR CARCINOMA: DIAGNOSTIC CHALLENGESSana Ben-Slamahttps://orcid.org/0000-0001-8897-398XInes Mallekhttps://orcid.org/0009-0009-9269-8365Eya Ghorbelihttps://orcid.org/0009-0004-6173-2691Mohamed Hajrihttps://orcid.org/0000-0002-1624-2923Taher Labidihttps://orcid.org/0009-0003-0516-6763Hafedh Mestirihttps://orcid.org/0000-0001-7409-3324Ahlem Lahmarhttps://orcid.org/0000-0001-7071-4592Dhouha Bachahttps://orcid.org/0000-0002-8430-0072ABSTRACT BACKGROUND: Hepatocellular carcinoma (HCC) encompasses rare variants like chromophobe hepatocellular carcinoma (CHCC) characterized by distinct histological features and molecular profiles. CASE REPORT: A 56-year-old male with chronic hepatitis C, presenting pain in the right hypochondrium. Imaging revealed a solitary liver lesion, subsequently resected and histologically diagnosed as HCC. Macroscopic examination found a 4×4 cm encapsulated liver nodule with necrotic areas, surrounded by numerous smaller satellite nodules in Segment 6. The liver was in micronodular cirrhosis. Histologically, the tumor had focal trabecular or pseudoglandular patterns within a vascularized stroma. The cells were large, with clear to eosinophilic cytoplasm and hyperchromatic and pleomorphic nuclei with focal anaplastic features. No vascular invasion was noted in adjacent cirrhotic liver tissue. RESULTS: The final diagnosis was CHCC. Due to its rarity and overlapping characteristics with other hepatic tumors, CHCC poses diagnostic challenges. Accurate diagnosis necessitates thorough histopathological assessment and molecular testing. The identification of the alternative lengthening of telomeres phenotype may distinguish CHCC from conventional HCC and hold potential implications for targeted therapeutic approaches. CONCLUSIONS: Recognition of HCC variants is critical for effective management and underscores the need for continued research into its clinical behavior and therapeutic responses.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0102-67202024000100337&lng=en&tlng=enPathologyCarcinoma, HepatocellularLiver DiseasesTumor Cells, Cultured |
| spellingShingle | Sana Ben-Slama Ines Mallek Eya Ghorbeli Mohamed Hajri Taher Labidi Hafedh Mestiri Ahlem Lahmar Dhouha Bacha CHROMOPHOBE HEPATOCELLULAR CARCINOMA: DIAGNOSTIC CHALLENGES ABCD: Arquivos Brasileiros de Cirurgia Digestiva Pathology Carcinoma, Hepatocellular Liver Diseases Tumor Cells, Cultured |
| title | CHROMOPHOBE HEPATOCELLULAR CARCINOMA: DIAGNOSTIC CHALLENGES |
| title_full | CHROMOPHOBE HEPATOCELLULAR CARCINOMA: DIAGNOSTIC CHALLENGES |
| title_fullStr | CHROMOPHOBE HEPATOCELLULAR CARCINOMA: DIAGNOSTIC CHALLENGES |
| title_full_unstemmed | CHROMOPHOBE HEPATOCELLULAR CARCINOMA: DIAGNOSTIC CHALLENGES |
| title_short | CHROMOPHOBE HEPATOCELLULAR CARCINOMA: DIAGNOSTIC CHALLENGES |
| title_sort | chromophobe hepatocellular carcinoma diagnostic challenges |
| topic | Pathology Carcinoma, Hepatocellular Liver Diseases Tumor Cells, Cultured |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0102-67202024000100337&lng=en&tlng=en |
| work_keys_str_mv | AT sanabenslama chromophobehepatocellularcarcinomadiagnosticchallenges AT inesmallek chromophobehepatocellularcarcinomadiagnosticchallenges AT eyaghorbeli chromophobehepatocellularcarcinomadiagnosticchallenges AT mohamedhajri chromophobehepatocellularcarcinomadiagnosticchallenges AT taherlabidi chromophobehepatocellularcarcinomadiagnosticchallenges AT hafedhmestiri chromophobehepatocellularcarcinomadiagnosticchallenges AT ahlemlahmar chromophobehepatocellularcarcinomadiagnosticchallenges AT dhouhabacha chromophobehepatocellularcarcinomadiagnosticchallenges |