Alcohol-induced gut permeability defect through dysbiosis and enterocytic mitochondrial interference causing pro-inflammatory macrophages in a dose dependent manner

Alcohol-induced gut permeability defect through dysbiosis and enterocytic mitochondrial interference causing pro-inflammatory macrophages in a dose dependent manner

Abstract Although toxicity of alcohol toward the intestines and immunity is mentioned, there might be different effect of alcohol in a low and a high dose and the rodent model development using a simple SHIRPA binary score night be useful. Hence, a low and high dose of alcohol (6.30 and 1.26 g/kg/da...

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Bibliographic Details
Main Authors: Wiwat Chancharoenthana, Supitcha Kamolratanakul, Kanyarat Udompornpitak, Dhammika Leshan Wannigama, Marcus J. Schultz, Asada Leelahavanichkul
Format: Article
Language:English
Published: Nature Portfolio 2025-04-01
Series:Scientific Reports
Subjects:
Endotoxin
Alcohol
Leaky gut
Mitochondria
Online Access:https://doi.org/10.1038/s41598-025-97593-0
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