First Report of a Novel Unbalanced Complex Variant Translocation t(3;9;22) with Ph Duplication and Evolving Triple Trisomy (8,12,21) in Newly Diagnosed Chronic Myeloid Leukemia without Blast Crisis: Resistance to Frontline Therapy

First Report of a Novel Unbalanced Complex Variant Translocation t(3;9;22) with Ph Duplication and Evolving Triple Trisomy (8,12,21) in Newly Diagnosed Chronic Myeloid Leukemia without Blast Crisis: Resistance to Frontline Therapy

In chronic myeloid leukemia (CML), tyrosine kinase inhibitors (TKIs) targeting the BCR/ABL1 fusion gene have transformed CML into a manageable condition. While most cases involve the standard t(9;22) translocation, 5 to 10% exhibit variant translocations and/or additional chromosomal abnormalities (...

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Bibliographic Details
Main Authors: Suhaib Mohammad Ali Abunaser, Shruti Prem Sudha, Anurita Pais
Format: Article
Language:English
Published: Thieme Medical and Scientific Publishers Pvt. Ltd.
Series:Indian Journal of Medical and Paediatric Oncology
Subjects:
chronic myeloid leukemia
variant translocation
karyotype
fluorescence in situ hybridization
imatinib
ponatinib
Online Access:http://www.thieme-connect.de/DOI/DOI?10.1055/s-0045-1809446
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Summary:In chronic myeloid leukemia (CML), tyrosine kinase inhibitors (TKIs) targeting the BCR/ABL1 fusion gene have transformed CML into a manageable condition. While most cases involve the standard t(9;22) translocation, 5 to 10% exhibit variant translocations and/or additional chromosomal abnormalities (ACAs), often linked to disease progression. Hence, cytogenetic analysis is crucial for monitoring clonal evolution and guiding treatment.
ISSN:0971-5851
0975-2129

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