MLKL deficiency elevates testosterone production in male mice independently of necroptotic functions
Abstract Mixed lineage kinase domain-like (MLKL) is a pseudokinase, best known for its role as the terminal effector of the necroptotic cell death pathway. MLKL-mediated necroptosis has long been linked to various age-related pathologies including neurodegeneration, atherosclerosis and male reproduc...
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| Main Authors: | Shene Chiou, Wayne Cawthorne, Thomas Soerianto, Vinzenz Hofferek, Komal M. Patel, Sarah E. Garnish, Emma C. Tovey Crutchfield, Cathrine Hall, Joanne M. Hildebrand, Malcolm J. McConville, Kate E. Lawlor, Edwin D. Hawkins, Andre L. Samson, James M. Murphy |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Nature Publishing Group
2024-11-01
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| Series: | Cell Death and Disease |
| Online Access: | https://doi.org/10.1038/s41419-024-07242-z |
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