Remnant cholesterol and risk of aortic aneurysm and dissection: a prospective cohort Study from the UK biobank study and mendelian randomization analysis
Abstract Aim This study aimed to examine the relationships between remnant cholesterol (RC) and the risk of aortic aneurysm and dissection (AAD). Methods This prospective cohort study included 368,139 European adults from the UK Biobank. Additionally, the causal relationship between RC and AAD was i...
Saved in:
| Main Authors: | , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
BMC
2025-02-01
|
| Series: | Lipids in Health and Disease |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s12944-025-02466-0 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1850191023631761408 |
|---|---|
| author | Ting Zhou Wenhui Lin Bangyuan Yang Yuan Liu Wenhui Huang Nianjin Xie Fan Yang Zhuoheng Lin Ziyang Hu Songyuan Luo Jianfang Luo |
| author_facet | Ting Zhou Wenhui Lin Bangyuan Yang Yuan Liu Wenhui Huang Nianjin Xie Fan Yang Zhuoheng Lin Ziyang Hu Songyuan Luo Jianfang Luo |
| author_sort | Ting Zhou |
| collection | DOAJ |
| description | Abstract Aim This study aimed to examine the relationships between remnant cholesterol (RC) and the risk of aortic aneurysm and dissection (AAD). Methods This prospective cohort study included 368,139 European adults from the UK Biobank. Additionally, the causal relationship between RC and AAD was investigated using Mendelian randomization (MR) analyses. Results During a median follow-up of 13.65 years, 1,634 cases of abdominal aortic aneurysm (AAA), 698 cases of thoracic aortic aneurysm (TAA), and 184 cases of aortic dissection (AD) were identified. Elevated RC levels were associated with an increased risk of AAA compared to the reference group ([highest vs. lowest RC levels]: adjusted hazard ratio (HR) = 1.65, 95% CI: 1.36–1.99). However, no significant association was observed between high RC levels and the risk of either TAA or AD. Two-sample MR analyses supported a significant causal effect of RC on AAA risk (odds ratio (OR) = 2.08, 95% CI: 1.70–2.56). The association between RC and AAA persisted after adjusting for the effects of RC-associated genetic variants on low-density lipoprotein cholesterol (LDL-C). In contrast, MR analyses did not indicate any causal associations between RC and TAA or AD. Conclusions Elevated RC was linked to a greater risk of developing AAA, with MR analyses confirming a causal relationship. These findings suggest that RC may function as a new biomarker for AAA and could be integral to strategies aimed at preventing AAA. |
| format | Article |
| id | doaj-art-3e959d43594e4060995adc7bdf1e52dd |
| institution | OA Journals |
| issn | 1476-511X |
| language | English |
| publishDate | 2025-02-01 |
| publisher | BMC |
| record_format | Article |
| series | Lipids in Health and Disease |
| spelling | doaj-art-3e959d43594e4060995adc7bdf1e52dd2025-08-20T02:15:02ZengBMCLipids in Health and Disease1476-511X2025-02-0124111410.1186/s12944-025-02466-0Remnant cholesterol and risk of aortic aneurysm and dissection: a prospective cohort Study from the UK biobank study and mendelian randomization analysisTing Zhou0Wenhui Lin1Bangyuan Yang2Yuan Liu3Wenhui Huang4Nianjin Xie5Fan Yang6Zhuoheng Lin7Ziyang Hu8Songyuan Luo9Jianfang Luo10Department of Cardiovascular, Guangdong Provincial People’s Hospital (Guangdong Academy of Medical Sciences), Southern Medical UniversityGuangdong Cardiovascular Institute, Guangdong Provincial Key Laboratory of Coronary Heart Disease Prevention, Guangdong Provincial Department of Cardiology, Guangdong Provincial People’s Hospital (Guangdong Academy of Medical Sciences), Southern Medical UniversityDepartment of Cardiovascular, Guangdong Provincial People’s Hospital (Guangdong Academy of Medical Sciences), Southern Medical UniversityGuangdong Cardiovascular Institute, Guangdong Provincial Key Laboratory of Coronary Heart Disease Prevention, Guangdong Provincial Department of Cardiology, Guangdong Provincial People’s Hospital (Guangdong Academy of Medical Sciences), Southern Medical UniversityGuangdong Cardiovascular Institute, Guangdong Provincial Key Laboratory of Coronary Heart Disease Prevention, Guangdong Provincial Department of Cardiology, Guangdong Provincial People’s Hospital (Guangdong Academy of Medical Sciences), Southern Medical UniversityGuangdong Cardiovascular Institute, Guangdong Provincial Key Laboratory of Coronary Heart Disease Prevention, Guangdong Provincial Department of Cardiology, Guangdong Provincial People’s Hospital (Guangdong Academy of Medical Sciences), Southern Medical UniversityDepartment of Emergency and Critical Care Medicine, Guangdong Provincial People’s Hospital, Guangdong Academy of Medical SciencesDepartment of Cardiovascular, Guangdong Provincial People’s Hospital (Guangdong Academy of Medical Sciences), Southern Medical UniversityGuangdong Cardiovascular Institute, Guangdong Provincial Key Laboratory of Coronary Heart Disease Prevention, Guangdong Provincial Department of Cardiology, Guangdong Provincial People’s Hospital (Guangdong Academy of Medical Sciences), Southern Medical UniversityDepartment of Cardiology, Guangdong Cardiovascular Institute, Guangdong Provincial Key Laboratory of Coronary Heart Disease Prevention, Ganzhou Municipal Hospital, Southern Medical University, Guangdong Provincial People’s Hospital (Guangdong Academy of Medical Sciences)Guangdong Cardiovascular Institute, Guangdong Provincial Key Laboratory of Coronary Heart Disease Prevention, Guangdong Provincial Department of Cardiology, Guangdong Provincial People’s Hospital (Guangdong Academy of Medical Sciences), Southern Medical UniversityAbstract Aim This study aimed to examine the relationships between remnant cholesterol (RC) and the risk of aortic aneurysm and dissection (AAD). Methods This prospective cohort study included 368,139 European adults from the UK Biobank. Additionally, the causal relationship between RC and AAD was investigated using Mendelian randomization (MR) analyses. Results During a median follow-up of 13.65 years, 1,634 cases of abdominal aortic aneurysm (AAA), 698 cases of thoracic aortic aneurysm (TAA), and 184 cases of aortic dissection (AD) were identified. Elevated RC levels were associated with an increased risk of AAA compared to the reference group ([highest vs. lowest RC levels]: adjusted hazard ratio (HR) = 1.65, 95% CI: 1.36–1.99). However, no significant association was observed between high RC levels and the risk of either TAA or AD. Two-sample MR analyses supported a significant causal effect of RC on AAA risk (odds ratio (OR) = 2.08, 95% CI: 1.70–2.56). The association between RC and AAA persisted after adjusting for the effects of RC-associated genetic variants on low-density lipoprotein cholesterol (LDL-C). In contrast, MR analyses did not indicate any causal associations between RC and TAA or AD. Conclusions Elevated RC was linked to a greater risk of developing AAA, with MR analyses confirming a causal relationship. These findings suggest that RC may function as a new biomarker for AAA and could be integral to strategies aimed at preventing AAA.https://doi.org/10.1186/s12944-025-02466-0Remnant cholesterolAbdominal aortic aneurysmAortic dissectionThoracic aortic aneurysmMendelian randomization analysis |
| spellingShingle | Ting Zhou Wenhui Lin Bangyuan Yang Yuan Liu Wenhui Huang Nianjin Xie Fan Yang Zhuoheng Lin Ziyang Hu Songyuan Luo Jianfang Luo Remnant cholesterol and risk of aortic aneurysm and dissection: a prospective cohort Study from the UK biobank study and mendelian randomization analysis Lipids in Health and Disease Remnant cholesterol Abdominal aortic aneurysm Aortic dissection Thoracic aortic aneurysm Mendelian randomization analysis |
| title | Remnant cholesterol and risk of aortic aneurysm and dissection: a prospective cohort Study from the UK biobank study and mendelian randomization analysis |
| title_full | Remnant cholesterol and risk of aortic aneurysm and dissection: a prospective cohort Study from the UK biobank study and mendelian randomization analysis |
| title_fullStr | Remnant cholesterol and risk of aortic aneurysm and dissection: a prospective cohort Study from the UK biobank study and mendelian randomization analysis |
| title_full_unstemmed | Remnant cholesterol and risk of aortic aneurysm and dissection: a prospective cohort Study from the UK biobank study and mendelian randomization analysis |
| title_short | Remnant cholesterol and risk of aortic aneurysm and dissection: a prospective cohort Study from the UK biobank study and mendelian randomization analysis |
| title_sort | remnant cholesterol and risk of aortic aneurysm and dissection a prospective cohort study from the uk biobank study and mendelian randomization analysis |
| topic | Remnant cholesterol Abdominal aortic aneurysm Aortic dissection Thoracic aortic aneurysm Mendelian randomization analysis |
| url | https://doi.org/10.1186/s12944-025-02466-0 |
| work_keys_str_mv | AT tingzhou remnantcholesterolandriskofaorticaneurysmanddissectionaprospectivecohortstudyfromtheukbiobankstudyandmendelianrandomizationanalysis AT wenhuilin remnantcholesterolandriskofaorticaneurysmanddissectionaprospectivecohortstudyfromtheukbiobankstudyandmendelianrandomizationanalysis AT bangyuanyang remnantcholesterolandriskofaorticaneurysmanddissectionaprospectivecohortstudyfromtheukbiobankstudyandmendelianrandomizationanalysis AT yuanliu remnantcholesterolandriskofaorticaneurysmanddissectionaprospectivecohortstudyfromtheukbiobankstudyandmendelianrandomizationanalysis AT wenhuihuang remnantcholesterolandriskofaorticaneurysmanddissectionaprospectivecohortstudyfromtheukbiobankstudyandmendelianrandomizationanalysis AT nianjinxie remnantcholesterolandriskofaorticaneurysmanddissectionaprospectivecohortstudyfromtheukbiobankstudyandmendelianrandomizationanalysis AT fanyang remnantcholesterolandriskofaorticaneurysmanddissectionaprospectivecohortstudyfromtheukbiobankstudyandmendelianrandomizationanalysis AT zhuohenglin remnantcholesterolandriskofaorticaneurysmanddissectionaprospectivecohortstudyfromtheukbiobankstudyandmendelianrandomizationanalysis AT ziyanghu remnantcholesterolandriskofaorticaneurysmanddissectionaprospectivecohortstudyfromtheukbiobankstudyandmendelianrandomizationanalysis AT songyuanluo remnantcholesterolandriskofaorticaneurysmanddissectionaprospectivecohortstudyfromtheukbiobankstudyandmendelianrandomizationanalysis AT jianfangluo remnantcholesterolandriskofaorticaneurysmanddissectionaprospectivecohortstudyfromtheukbiobankstudyandmendelianrandomizationanalysis |