Alkoxy Substituted Brominated <i>closo</i>-Dodecaborates with Functionalized Aliphatic Spacers
The utilization of dodecaborate boron clusters, [B<sub>12</sub>X<sub>12</sub>]<sup>2−</sup> (X = Cl, Br, or I), as membrane carriers has been demonstrated recently, and their activity is known to be due to their superchaotropic nature. In this work, the mono-alkyl...
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| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2024-12-01
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| Series: | Chemistry |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2624-8549/6/6/99 |
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| Summary: | The utilization of dodecaborate boron clusters, [B<sub>12</sub>X<sub>12</sub>]<sup>2−</sup> (X = Cl, Br, or I), as membrane carriers has been demonstrated recently, and their activity is known to be due to their superchaotropic nature. In this work, the mono-alkylation of [B<sub>12</sub>Br<sub>11</sub>OH]<sup>2−</sup> to functionalize it with an aliphatic spacer was developed with a view to expanding the known chemical space of membrane carriers based on [B<sub>12</sub>Br<sub>12</sub>]<sup>2−</sup>. A new and improved facile route for the preparation of [B<sub>12</sub>Br<sub>11</sub>OH]<sup>2−</sup>, which is an important precursor to other [B<sub>12</sub>Br<sub>11</sub>OR]<sup>2−</sup> species, is reported. Various alkoxylated [B<sub>12</sub>Br<sub>11</sub>O(CH<sub>2</sub>)<sub>5</sub>Z]<sup>2−</sup> (Z = OH, N(CO)<sub>2</sub>C<sub>6</sub>H<sub>4</sub>, CN and N<sub>3</sub>) derivatives were prepared via a divergent synthesis based on [B<sub>12</sub>Br<sub>11</sub>O(CH<sub>2</sub>)<sub>5</sub>Br]<sup>2−</sup>. One of the newly synthesized compounds was utilized as a membrane carrier, and its impact on cell viability was examined. |
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| ISSN: | 2624-8549 |