Infection with Toxoplasma gondii does not Alter TNFα and IL-6 Secretion by A human Astrocytoma Cell Line
The secretion of tumour necrosis factor-α (TNFα), interleukin-1α (IL-α) and interleukin-6 (IL-6) by a human astrocytoma cell fine was studied 1 h, 3 h, 6 h and 24 h after infection with tachyzoites from three Toxoplasma gondii strains (virulent, RH; cystogentc, 76K and Prugniaud strains). The astroc...
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| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Wiley
1994-01-01
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| Series: | Mediators of Inflammation |
| Online Access: | http://dx.doi.org/10.1155/S0962935194000402 |
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| Summary: | The secretion of tumour necrosis factor-α (TNFα),
interleukin-1α (IL-α) and interleukin-6 (IL-6) by a
human astrocytoma cell fine was studied 1 h, 3 h, 6 h and 24 h after
infection with tachyzoites from three Toxoplasma gondii
strains (virulent, RH; cystogentc, 76K and Prugniaud strains). The
astrocytoma cell fine constitutively secreted TNFα and IL-6,
but no IL-1α. A positive control was obtained by stimulation
with phorbol esters inducing a significant increase (p<0.05) in TNFα and IL- 6 secretion but not in IL-1α, while
lipopolysaccharide (alone and after priming), interferon gamma,
ionophore A 23187 and sera positive to T. gondii did
not induce any increase in cytokine levels. None of the tachyzoites,
whatever their virulence, induced a significant increase in cytokine
production at any time in the study. Tachyzoites did not inhibit the
secretion induced by phorbol esters. |
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| ISSN: | 0962-9351 1466-1861 |