Exploiting CRISPR/Cas system in controlling antibiotic resistance of bacteria
The emergence and spread of antimicrobial resistance is a threat to human health, therefore there is a need to explore new strategies to combat antibiotic-resistant bacteria. Antimicrobial resistance genes are mainly transmitted through horizontal gene transfer (HGT) mediated by transposable element...
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| Format: | Article |
| Language: | English |
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Tabriz: Hamid Allahverdipour, 2024-
2024-07-01
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| Series: | BioSocial Health Journal |
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| Online Access: | https://biosocialhealthjournal.com/PDF/bshj-1-61.pdf |
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| author | Pourya Gholizadeh Elnaz Faghfuri Khudaverdi Ganbarov Hossein Samadi Kafil |
| author_facet | Pourya Gholizadeh Elnaz Faghfuri Khudaverdi Ganbarov Hossein Samadi Kafil |
| author_sort | Pourya Gholizadeh |
| collection | DOAJ |
| description | The emergence and spread of antimicrobial resistance is a threat to human health, therefore there is a need to explore new strategies to combat antibiotic-resistant bacteria. Antimicrobial resistance genes are mainly transmitted through horizontal gene transfer (HGT) mediated by transposable elements, phages, and plasmids, which leads to the emergence of multidrug-resistant bacteria. Clustered Regularly interspaced Short Palindromic Repeats (CRISPR) and CRISPR-associated proteins (Cas) protect archaebacteria and eubacteria from potentially harmful foreign DNA such as plasmids, transposable elements, and phages. Several studies have introduced the CRISPR/Cas system as an innovative and effective strategy to trigger antibiotic resistance and virulent genes in bacteria. Therefore, this study aimed to introduce the CRISPR-Cas system in controlling antibiotic resistance of bacteria. We hope exploiting CRISPR/Cas could provide a bright future for the treatment of disastrous infections with resistant and virulent organisms. |
| format | Article |
| id | doaj-art-3e90085f9e4d40ac9b4c36881974be6d |
| institution | Kabale University |
| issn | 3060-6268 |
| language | English |
| publishDate | 2024-07-01 |
| publisher | Tabriz: Hamid Allahverdipour, 2024- |
| record_format | Article |
| series | BioSocial Health Journal |
| spelling | doaj-art-3e90085f9e4d40ac9b4c36881974be6d2025-02-06T10:33:12ZengTabriz: Hamid Allahverdipour, 2024-BioSocial Health Journal3060-62682024-07-0112616310.34172/bshj.20bshj-20Exploiting CRISPR/Cas system in controlling antibiotic resistance of bacteriaPourya Gholizadeh0Elnaz Faghfuri1Khudaverdi Ganbarov2Hossein Samadi Kafil3Digestive Disease Research Center, Ardabil University of Medical Sciences, Ardabil, IranDigestive Disease Research Center, Ardabil University of Medical Sciences, Ardabil, IranResearch laboratory of Microbiology and Virology, Baku State University, Baku, AzerbaijanDrug Applied Research Center, Tabriz University of Medical Sciences, Tabriz, IranThe emergence and spread of antimicrobial resistance is a threat to human health, therefore there is a need to explore new strategies to combat antibiotic-resistant bacteria. Antimicrobial resistance genes are mainly transmitted through horizontal gene transfer (HGT) mediated by transposable elements, phages, and plasmids, which leads to the emergence of multidrug-resistant bacteria. Clustered Regularly interspaced Short Palindromic Repeats (CRISPR) and CRISPR-associated proteins (Cas) protect archaebacteria and eubacteria from potentially harmful foreign DNA such as plasmids, transposable elements, and phages. Several studies have introduced the CRISPR/Cas system as an innovative and effective strategy to trigger antibiotic resistance and virulent genes in bacteria. Therefore, this study aimed to introduce the CRISPR-Cas system in controlling antibiotic resistance of bacteria. We hope exploiting CRISPR/Cas could provide a bright future for the treatment of disastrous infections with resistant and virulent organisms.https://biosocialhealthjournal.com/PDF/bshj-1-61.pdfcrispr/cas systemantibiotic-resistant bacteriagenome editingresensitization |
| spellingShingle | Pourya Gholizadeh Elnaz Faghfuri Khudaverdi Ganbarov Hossein Samadi Kafil Exploiting CRISPR/Cas system in controlling antibiotic resistance of bacteria BioSocial Health Journal crispr/cas system antibiotic-resistant bacteria genome editing resensitization |
| title | Exploiting CRISPR/Cas system in controlling antibiotic resistance of bacteria |
| title_full | Exploiting CRISPR/Cas system in controlling antibiotic resistance of bacteria |
| title_fullStr | Exploiting CRISPR/Cas system in controlling antibiotic resistance of bacteria |
| title_full_unstemmed | Exploiting CRISPR/Cas system in controlling antibiotic resistance of bacteria |
| title_short | Exploiting CRISPR/Cas system in controlling antibiotic resistance of bacteria |
| title_sort | exploiting crispr cas system in controlling antibiotic resistance of bacteria |
| topic | crispr/cas system antibiotic-resistant bacteria genome editing resensitization |
| url | https://biosocialhealthjournal.com/PDF/bshj-1-61.pdf |
| work_keys_str_mv | AT pouryagholizadeh exploitingcrisprcassystemincontrollingantibioticresistanceofbacteria AT elnazfaghfuri exploitingcrisprcassystemincontrollingantibioticresistanceofbacteria AT khudaverdiganbarov exploitingcrisprcassystemincontrollingantibioticresistanceofbacteria AT hosseinsamadikafil exploitingcrisprcassystemincontrollingantibioticresistanceofbacteria |