Protective effect of quercetin loaded on bifunctional periodic mesoporous organosilica against damage induced by irradiation on the male reproductive system
Abstract Preserving fertility is important in men under radiation therapy because healthy cells are also affected by radiation. Supplementation with antioxidants is a controversial issue in this process. Designing a biocompatible delivery system containing hydrophobic antioxidants to release control...
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| Format: | Article |
| Language: | English |
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Springer
2025-01-01
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| Series: | Journal of Materials Science: Materials in Medicine |
| Online Access: | https://doi.org/10.1007/s10856-024-06857-0 |
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| author | S. F. Mirtaheri S. N. Mousavi Z. Abdi E. Hosseini M. S. Seyed Dorraji F. Kabiri Esfahani M. Gholami |
| author_facet | S. F. Mirtaheri S. N. Mousavi Z. Abdi E. Hosseini M. S. Seyed Dorraji F. Kabiri Esfahani M. Gholami |
| author_sort | S. F. Mirtaheri |
| collection | DOAJ |
| description | Abstract Preserving fertility is important in men under radiation therapy because healthy cells are also affected by radiation. Supplementation with antioxidants is a controversial issue in this process. Designing a biocompatible delivery system containing hydrophobic antioxidants to release control may solve these disagreements. Herein, a bifunctional periodic mesoporous organosilica (PMO) was designed to load quercetin (Quer) and its application was studied on damaged cells induced by irradiation on the male reproductive system. Quercetin-loaded on PMO significantly improved the length and width of the testis after irradiation compared to the Quer, alone (p < 0.001 and p < 0.001, respectively). Sperm viability was significantly higher in the Quer-loaded on PMO than Quer, alone after irradiation (p < 0.001). Irradiation significantly decreased the sperm count (p = 0.01), however, Quer and Quer-loaded on PMO could not increase them to the normal ranges. Quer alone and loaded on PMO significantly reduced the sperm with abnormal morphology after irradiation (p < 0.001). Quer alone, and loaded on PMO significantly increased daily production of sperm after irradiation (p < 0.001). The number of apoptotic cells significantly increased after irradiation (p < 0.001). After irradiation, Quer loaded on PMO significantly decreased the apoptotic cells compared to the irradiated (p < 0.001) and Quer, alone groups (p < 0.001). The novel synthesized PMO containing Quer reduced the side effects of irradiation on the male reproductive system. Graphical Abstract |
| format | Article |
| id | doaj-art-3e8fa98087ad47a0af81af6368d74624 |
| institution | Kabale University |
| issn | 1573-4838 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Springer |
| record_format | Article |
| series | Journal of Materials Science: Materials in Medicine |
| spelling | doaj-art-3e8fa98087ad47a0af81af6368d746242025-01-19T12:08:11ZengSpringerJournal of Materials Science: Materials in Medicine1573-48382025-01-013611810.1007/s10856-024-06857-0Protective effect of quercetin loaded on bifunctional periodic mesoporous organosilica against damage induced by irradiation on the male reproductive systemS. F. Mirtaheri0S. N. Mousavi1Z. Abdi2E. Hosseini3M. S. Seyed Dorraji4F. Kabiri Esfahani5M. Gholami6Applied Chemistry Research Laboratory, Department of Chemistry, Faculty of Science, University of ZanjanDepartment of Nutrition, School of Public Health, Zanjan University of Medical SciencesDepartment of Anatomical Sciences, School of Medicine, Zanjan University of Medical SciencesZanjan Metabolic Diseases Research Center, Health and Metabolic Diseases Research Institute, Zanjan University of Medical SciencesApplied Chemistry Research Laboratory, Department of Chemistry, Faculty of Science, University of ZanjanApplied Chemistry Research Laboratory, Department of Chemistry, Faculty of Science, University of ZanjanApplied Chemistry Research Laboratory, Department of Chemistry, Faculty of Science, University of ZanjanAbstract Preserving fertility is important in men under radiation therapy because healthy cells are also affected by radiation. Supplementation with antioxidants is a controversial issue in this process. Designing a biocompatible delivery system containing hydrophobic antioxidants to release control may solve these disagreements. Herein, a bifunctional periodic mesoporous organosilica (PMO) was designed to load quercetin (Quer) and its application was studied on damaged cells induced by irradiation on the male reproductive system. Quercetin-loaded on PMO significantly improved the length and width of the testis after irradiation compared to the Quer, alone (p < 0.001 and p < 0.001, respectively). Sperm viability was significantly higher in the Quer-loaded on PMO than Quer, alone after irradiation (p < 0.001). Irradiation significantly decreased the sperm count (p = 0.01), however, Quer and Quer-loaded on PMO could not increase them to the normal ranges. Quer alone and loaded on PMO significantly reduced the sperm with abnormal morphology after irradiation (p < 0.001). Quer alone, and loaded on PMO significantly increased daily production of sperm after irradiation (p < 0.001). The number of apoptotic cells significantly increased after irradiation (p < 0.001). After irradiation, Quer loaded on PMO significantly decreased the apoptotic cells compared to the irradiated (p < 0.001) and Quer, alone groups (p < 0.001). The novel synthesized PMO containing Quer reduced the side effects of irradiation on the male reproductive system. Graphical Abstracthttps://doi.org/10.1007/s10856-024-06857-0 |
| spellingShingle | S. F. Mirtaheri S. N. Mousavi Z. Abdi E. Hosseini M. S. Seyed Dorraji F. Kabiri Esfahani M. Gholami Protective effect of quercetin loaded on bifunctional periodic mesoporous organosilica against damage induced by irradiation on the male reproductive system Journal of Materials Science: Materials in Medicine |
| title | Protective effect of quercetin loaded on bifunctional periodic mesoporous organosilica against damage induced by irradiation on the male reproductive system |
| title_full | Protective effect of quercetin loaded on bifunctional periodic mesoporous organosilica against damage induced by irradiation on the male reproductive system |
| title_fullStr | Protective effect of quercetin loaded on bifunctional periodic mesoporous organosilica against damage induced by irradiation on the male reproductive system |
| title_full_unstemmed | Protective effect of quercetin loaded on bifunctional periodic mesoporous organosilica against damage induced by irradiation on the male reproductive system |
| title_short | Protective effect of quercetin loaded on bifunctional periodic mesoporous organosilica against damage induced by irradiation on the male reproductive system |
| title_sort | protective effect of quercetin loaded on bifunctional periodic mesoporous organosilica against damage induced by irradiation on the male reproductive system |
| url | https://doi.org/10.1007/s10856-024-06857-0 |
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