Exploration of differential expression and biological significance of amino acid metabolism genes in osteoarthritis

Exploration of differential expression and biological significance of amino acid metabolism genes in osteoarthritis

BackgroundOsteoarthritis (OA) is a widespread disorder affecting joints, recognized for cartilage wear and inflammatory responses, which substantially affects patients’ quality of life. This research aim to discover amino acid metabolism-related differentially expressed genes (AAMRDEGs) and clarify...

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Main Authors: Zhenghuan Zhu, Jiaqing Meng, Junfeng Hu, Lingmin Hu, Wenge Ding, Wanchao Zhang, Chuang Zhao, Lin Feng, Kejie Wang
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-07-01
Series:Frontiers in Immunology
Subjects:
osteoarthritis
amino acid metabolism genes
weighted gene co-expression network analysis
immunity-related genes
immune infiltration
lasso regression
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2025.1588072/full
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