Polycythemia vera with acute coronary syndrome and bleeding as initial presentation: A case report and literature review
Polycythemia vera (PV) is a chronic myeloproliferative disorder characterized by increased red blood cell mass, leading to a heightened risk for thrombosis and hemorrhage. While thrombotic complications such as stroke, deep vein thrombosis, and pulmonary embolism are commonly associated with PV, cor...
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| Format: | Article |
| Language: | English |
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Elsevier
2025-02-01
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| Series: | Radiology Case Reports |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S1930043324012172 |
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| author | Rabia Iqbal, MBBS Aemen Shafqat Bazaz, MBBS Ahmad Taimoor Bajwa, MBBS Hnin Nadi Linn, MD Nyan Linn Htet, MD Sabrin Marowa, MD Asmat Ullah, MD |
| author_facet | Rabia Iqbal, MBBS Aemen Shafqat Bazaz, MBBS Ahmad Taimoor Bajwa, MBBS Hnin Nadi Linn, MD Nyan Linn Htet, MD Sabrin Marowa, MD Asmat Ullah, MD |
| author_sort | Rabia Iqbal, MBBS |
| collection | DOAJ |
| description | Polycythemia vera (PV) is a chronic myeloproliferative disorder characterized by increased red blood cell mass, leading to a heightened risk for thrombosis and hemorrhage. While thrombotic complications such as stroke, deep vein thrombosis, and pulmonary embolism are commonly associated with PV, coronary artery syndromes, as the initial presentation, are rare. Here, we present the case of a 73-year-old male who presented with severe chest pain and was diagnosed with non-ST–elevation myocardial infarction (NSTEMI). During his hospitalization, the patient experienced spontaneous psoas muscle hemorrhage, which prompted further investigation. Laboratory workup revealed elevated hemoglobin levels and a positive JAK2 V617F mutation, confirming a diagnosis of polycythemia vera. This case highlights the importance of considering myeloproliferative disorders in patients with atypical thrombotic and hemorrhagic events. It emphasizes the need for early diagnosis and appropriate treatment to optimize patient outcomes. |
| format | Article |
| id | doaj-art-3e892de419d84abaa503b89fd9fb500c |
| institution | OA Journals |
| issn | 1930-0433 |
| language | English |
| publishDate | 2025-02-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Radiology Case Reports |
| spelling | doaj-art-3e892de419d84abaa503b89fd9fb500c2025-08-20T01:57:55ZengElsevierRadiology Case Reports1930-04332025-02-0120290991510.1016/j.radcr.2024.10.109Polycythemia vera with acute coronary syndrome and bleeding as initial presentation: A case report and literature reviewRabia Iqbal, MBBS0Aemen Shafqat Bazaz, MBBS1Ahmad Taimoor Bajwa, MBBS2Hnin Nadi Linn, MD3Nyan Linn Htet, MD4Sabrin Marowa, MD5Asmat Ullah, MD6Department of Internal Medicine, The Brooklyn Hospital Center, New York, NY, USARawalpindi Medical University, Rawalpindi, PakistanDepartment of Internal Medicine, The Brooklyn Hospital Center, New York, NY, USADepartment of Internal Medicine, The Brooklyn Hospital Center, New York, NY, USADepartment of Internal Medicine, The Brooklyn Hospital Center, New York, NY, USAZainul Haque Sikder Women's Medical College and Hospital, Dhaka, Bangladesh; Corresponding author.Department of Hematology and Oncology, The Brooklyn Hospital Center, New York, NY, USAPolycythemia vera (PV) is a chronic myeloproliferative disorder characterized by increased red blood cell mass, leading to a heightened risk for thrombosis and hemorrhage. While thrombotic complications such as stroke, deep vein thrombosis, and pulmonary embolism are commonly associated with PV, coronary artery syndromes, as the initial presentation, are rare. Here, we present the case of a 73-year-old male who presented with severe chest pain and was diagnosed with non-ST–elevation myocardial infarction (NSTEMI). During his hospitalization, the patient experienced spontaneous psoas muscle hemorrhage, which prompted further investigation. Laboratory workup revealed elevated hemoglobin levels and a positive JAK2 V617F mutation, confirming a diagnosis of polycythemia vera. This case highlights the importance of considering myeloproliferative disorders in patients with atypical thrombotic and hemorrhagic events. It emphasizes the need for early diagnosis and appropriate treatment to optimize patient outcomes.http://www.sciencedirect.com/science/article/pii/S1930043324012172Polycythemia veraAcute coronary syndromeMyeloproliferative disordersThromboembolic events |
| spellingShingle | Rabia Iqbal, MBBS Aemen Shafqat Bazaz, MBBS Ahmad Taimoor Bajwa, MBBS Hnin Nadi Linn, MD Nyan Linn Htet, MD Sabrin Marowa, MD Asmat Ullah, MD Polycythemia vera with acute coronary syndrome and bleeding as initial presentation: A case report and literature review Radiology Case Reports Polycythemia vera Acute coronary syndrome Myeloproliferative disorders Thromboembolic events |
| title | Polycythemia vera with acute coronary syndrome and bleeding as initial presentation: A case report and literature review |
| title_full | Polycythemia vera with acute coronary syndrome and bleeding as initial presentation: A case report and literature review |
| title_fullStr | Polycythemia vera with acute coronary syndrome and bleeding as initial presentation: A case report and literature review |
| title_full_unstemmed | Polycythemia vera with acute coronary syndrome and bleeding as initial presentation: A case report and literature review |
| title_short | Polycythemia vera with acute coronary syndrome and bleeding as initial presentation: A case report and literature review |
| title_sort | polycythemia vera with acute coronary syndrome and bleeding as initial presentation a case report and literature review |
| topic | Polycythemia vera Acute coronary syndrome Myeloproliferative disorders Thromboembolic events |
| url | http://www.sciencedirect.com/science/article/pii/S1930043324012172 |
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