Identification of broad-spectrum Mpro inhibitors: a focus on high-risk coronaviruses and conserved interactions

Identification of broad-spectrum Mpro inhibitors: a focus on high-risk coronaviruses and conserved interactions

The COVID-19 pandemic underscores the urgent need to develop broad-spectrum antivirals against coronaviruses (CoVs) to prepare for future outbreaks. In this study, we presented a systematic approach to developing broad-spectrum Mpro inhibitors, with a focus on high-risk CoVs. We optimised S-217622 a...

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Main Authors: Man Liu, Li Zhao, Xupeng Huang, Zhenhao Tang, Yihang Zhong, Mengrong Yan, Shun Liu, Shunjing Wang, Zeyun Sun, Zixuan Rao, Linyi Yu, Yuying Fang, Wei Zhang, Hongbo Zhang, Wei Peng
Format: Article
Language:English
Published: Taylor & Francis Group 2025-12-01
Series:Journal of Enzyme Inhibition and Medicinal Chemistry
Subjects:
Broad-spectrum
conserved interactions
Mpro inhibitors
Online Access:https://www.tandfonline.com/doi/10.1080/14756366.2025.2503961
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