Evaluation of oxidative stress in dogs and cats with chronic kidney disease
Abstract Background Oxidative stress is a potential contributor to chronic kidney disease (CKD) progression but has not been evaluated in dogs and cats with CKD. Hypothesis Oxidative stress is higher in animals with CKD compared with healthy controls and decreases with the advancing CKD stage. The a...
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Wiley
2024-11-01
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| Series: | Journal of Veterinary Internal Medicine |
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| Online Access: | https://doi.org/10.1111/jvim.17230 |
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| author | Hilla Chen Gilad Segev |
| author_facet | Hilla Chen Gilad Segev |
| author_sort | Hilla Chen |
| collection | DOAJ |
| description | Abstract Background Oxidative stress is a potential contributor to chronic kidney disease (CKD) progression but has not been evaluated in dogs and cats with CKD. Hypothesis Oxidative stress is higher in animals with CKD compared with healthy controls and decreases with the advancing CKD stage. The aim of this study was to determine the presence and intensity of oxidative stress in dogs and cats at different CKD stages. Animals Sixty dogs and 30 cats with naturally acquired CKD; 10 dogs and 14 cats, healthy controls. Methods Analytical cross‐sectional study. Oxidative stress was evaluated by measuring the urinary concentration of F2‐isoprostane (uF2‐IsoPs) normalized to urinary creatinine. Results Urinary F2‐isoprostanes normalized to urinary creatinine of healthy dogs and of dogs with CKD Stages 1 to 4 was 3.3 ng/mg, 4.7 ng/mg (range, 1.0‐73.4), 2.4 ng/mg (range, 0.4‐7.8), 0.52 ng/mg (range, 0.01‐2.9), and 0.37 ng/mg (range, 0.01‐0.6), respectively. Urinary F2‐isoprostanes differed among CKD stages (P < .001), but not compared with controls. uF2‐IsoPs of healthy cats and cats with CKD Stages 1 to 4 was 0.68 ng/mg (range, 0.2‐1.4), 0.97 ng/mg (range, 0.4‐1.8), 0.6 ng/mg (range, 0.002‐2.0), 0.94 ng/mg (range, 0.3‐2.3), and 0.2 ng/mg (range, 0.01‐0.4). Urinary F2‐isoprostanes differed among stages (P = .05) but not compared with healthy controls. Conclusion and Clinical Importance Oxidative stress might be present in dogs and cats with CKD. Its magnitude declines as the disease progresses, therefore, it should be considered a potential therapeutic target mostly at the early stages of the disease. |
| format | Article |
| id | doaj-art-3e855e0da54e43c19be2035d7189539f |
| institution | OA Journals |
| issn | 0891-6640 1939-1676 |
| language | English |
| publishDate | 2024-11-01 |
| publisher | Wiley |
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| series | Journal of Veterinary Internal Medicine |
| spelling | doaj-art-3e855e0da54e43c19be2035d7189539f2025-08-20T02:23:40ZengWileyJournal of Veterinary Internal Medicine0891-66401939-16762024-11-013863105311010.1111/jvim.17230Evaluation of oxidative stress in dogs and cats with chronic kidney diseaseHilla Chen0Gilad Segev1Department of Small Animal Internal Medicine Koret School of Veterinary Medicine, The Hebrew University of Jerusalem Rehovot IsraelDepartment of Small Animal Internal Medicine Koret School of Veterinary Medicine, The Hebrew University of Jerusalem Rehovot IsraelAbstract Background Oxidative stress is a potential contributor to chronic kidney disease (CKD) progression but has not been evaluated in dogs and cats with CKD. Hypothesis Oxidative stress is higher in animals with CKD compared with healthy controls and decreases with the advancing CKD stage. The aim of this study was to determine the presence and intensity of oxidative stress in dogs and cats at different CKD stages. Animals Sixty dogs and 30 cats with naturally acquired CKD; 10 dogs and 14 cats, healthy controls. Methods Analytical cross‐sectional study. Oxidative stress was evaluated by measuring the urinary concentration of F2‐isoprostane (uF2‐IsoPs) normalized to urinary creatinine. Results Urinary F2‐isoprostanes normalized to urinary creatinine of healthy dogs and of dogs with CKD Stages 1 to 4 was 3.3 ng/mg, 4.7 ng/mg (range, 1.0‐73.4), 2.4 ng/mg (range, 0.4‐7.8), 0.52 ng/mg (range, 0.01‐2.9), and 0.37 ng/mg (range, 0.01‐0.6), respectively. Urinary F2‐isoprostanes differed among CKD stages (P < .001), but not compared with controls. uF2‐IsoPs of healthy cats and cats with CKD Stages 1 to 4 was 0.68 ng/mg (range, 0.2‐1.4), 0.97 ng/mg (range, 0.4‐1.8), 0.6 ng/mg (range, 0.002‐2.0), 0.94 ng/mg (range, 0.3‐2.3), and 0.2 ng/mg (range, 0.01‐0.4). Urinary F2‐isoprostanes differed among stages (P = .05) but not compared with healthy controls. Conclusion and Clinical Importance Oxidative stress might be present in dogs and cats with CKD. Its magnitude declines as the disease progresses, therefore, it should be considered a potential therapeutic target mostly at the early stages of the disease.https://doi.org/10.1111/jvim.17230biomarkersCKD progressionF2‐isprostanesproteinuriarenal diet |
| spellingShingle | Hilla Chen Gilad Segev Evaluation of oxidative stress in dogs and cats with chronic kidney disease Journal of Veterinary Internal Medicine biomarkers CKD progression F2‐isprostanes proteinuria renal diet |
| title | Evaluation of oxidative stress in dogs and cats with chronic kidney disease |
| title_full | Evaluation of oxidative stress in dogs and cats with chronic kidney disease |
| title_fullStr | Evaluation of oxidative stress in dogs and cats with chronic kidney disease |
| title_full_unstemmed | Evaluation of oxidative stress in dogs and cats with chronic kidney disease |
| title_short | Evaluation of oxidative stress in dogs and cats with chronic kidney disease |
| title_sort | evaluation of oxidative stress in dogs and cats with chronic kidney disease |
| topic | biomarkers CKD progression F2‐isprostanes proteinuria renal diet |
| url | https://doi.org/10.1111/jvim.17230 |
| work_keys_str_mv | AT hillachen evaluationofoxidativestressindogsandcatswithchronickidneydisease AT giladsegev evaluationofoxidativestressindogsandcatswithchronickidneydisease |