Salivary Antibody Responses to Potentially Waterborne and Environmentally Transmitted Infections Among Two Tribal Nations in the Southwest United States
Abstract Purpose Tribal Nations disproportionately lack access to safe drinking water and can be adversely affected by other water quality and environmental concerns. Such conditions could lead to an increase in the transmission of waterborne, environmental and hygiene related infections. We collect...
Saved in:
| Main Authors: | , , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Springer
2024-11-01
|
| Series: | Journal of Epidemiology and Global Health |
| Subjects: | |
| Online Access: | https://doi.org/10.1007/s44197-024-00315-4 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1850254195976830976 |
|---|---|
| author | Timothy J. Wade Jatin H. Mistry Swinburne A. J. Augustine Shannon M. Griffin Jason Kobylanski Jennifer Styles Elizabeth Sams Edward Hudgens Megan Kowalcyk Wesley Cochran Honorine Ward Andrey Egorov |
| author_facet | Timothy J. Wade Jatin H. Mistry Swinburne A. J. Augustine Shannon M. Griffin Jason Kobylanski Jennifer Styles Elizabeth Sams Edward Hudgens Megan Kowalcyk Wesley Cochran Honorine Ward Andrey Egorov |
| author_sort | Timothy J. Wade |
| collection | DOAJ |
| description | Abstract Purpose Tribal Nations disproportionately lack access to safe drinking water and can be adversely affected by other water quality and environmental concerns. Such conditions could lead to an increase in the transmission of waterborne, environmental and hygiene related infections. We collected saliva samples from attendees at two Tribal Nation annual festivals and tested them for salivary immunoglobulin G (IgG) responses to selected common infections using an in-house multiplex immunoassay. Antibody responses were compared to responses from a previously conducted study in the midwestern United States. Methods We collected and tested 531 samples from Tribal Nation sites and used data on 453 previously analyzed samples from the Midwest site. Logistic and linear regression models were used to model a binary classification of seropositivity and the intensity of the antibody response, respectively. Results Seroprevalence of chronic infections (Helicobacter pylori and Toxoplasma gondii) were generally consistent with estimates from population-based studies. Compared to the Midwest site, one of the Tribal Nation sites had consistently higher median antibody responses to several noroviruses. The Tribal Nation sites had a lower seroprevalence of hepatitis E virus antibodies. At the Tribal Nation sites, farm residents had higher antibody responses to Cryptosporidium spp., bottled water consumption was associated with lower responses to Cryptosporidium spp., animal contact was associated with T. gondii seropositivity, and recent diarrhea was associated with higher norovirus antibody responses. Helicobacter pylori seropositivity was associated with reduced odds of reporting allergies. Conclusion This study demonstrated the application of a multiplex salivary immunoassay in Tribal Nations to provide insights regarding selected common pathogens which are transmitted through different transmission pathways including person-to-person contacts, contaminated food, soil and drinking water. |
| format | Article |
| id | doaj-art-3e833d80ef79415cb06812018ed3b5f7 |
| institution | OA Journals |
| issn | 2210-6014 |
| language | English |
| publishDate | 2024-11-01 |
| publisher | Springer |
| record_format | Article |
| series | Journal of Epidemiology and Global Health |
| spelling | doaj-art-3e833d80ef79415cb06812018ed3b5f72025-08-20T01:57:11ZengSpringerJournal of Epidemiology and Global Health2210-60142024-11-011441619163210.1007/s44197-024-00315-4Salivary Antibody Responses to Potentially Waterborne and Environmentally Transmitted Infections Among Two Tribal Nations in the Southwest United StatesTimothy J. Wade0Jatin H. Mistry1Swinburne A. J. Augustine2Shannon M. Griffin3Jason Kobylanski4Jennifer Styles5Elizabeth Sams6Edward Hudgens7Megan Kowalcyk8Wesley Cochran9Honorine Ward10Andrey Egorov11Office of Research and Development, United States Environmental Protection AgencyRegion 6, United States Environmental Protection AgencyOffice of Research and Development, United States Environmental Protection AgencyOffice of Research and Development, United States Environmental Protection AgencyORAU Student Services Contractor, United States Environmental Protection AgencyORAU Student Services Contractor, United States Environmental Protection AgencyOffice of Research and Development, United States Environmental Protection AgencyOffice of Research and Development, United States Environmental Protection AgencyORAU Student Services Contractor, United States Environmental Protection AgencyORAU Student Services Contractor, United States Environmental Protection AgencyTufts Medical CenterOffice of Research and Development, United States Environmental Protection AgencyAbstract Purpose Tribal Nations disproportionately lack access to safe drinking water and can be adversely affected by other water quality and environmental concerns. Such conditions could lead to an increase in the transmission of waterborne, environmental and hygiene related infections. We collected saliva samples from attendees at two Tribal Nation annual festivals and tested them for salivary immunoglobulin G (IgG) responses to selected common infections using an in-house multiplex immunoassay. Antibody responses were compared to responses from a previously conducted study in the midwestern United States. Methods We collected and tested 531 samples from Tribal Nation sites and used data on 453 previously analyzed samples from the Midwest site. Logistic and linear regression models were used to model a binary classification of seropositivity and the intensity of the antibody response, respectively. Results Seroprevalence of chronic infections (Helicobacter pylori and Toxoplasma gondii) were generally consistent with estimates from population-based studies. Compared to the Midwest site, one of the Tribal Nation sites had consistently higher median antibody responses to several noroviruses. The Tribal Nation sites had a lower seroprevalence of hepatitis E virus antibodies. At the Tribal Nation sites, farm residents had higher antibody responses to Cryptosporidium spp., bottled water consumption was associated with lower responses to Cryptosporidium spp., animal contact was associated with T. gondii seropositivity, and recent diarrhea was associated with higher norovirus antibody responses. Helicobacter pylori seropositivity was associated with reduced odds of reporting allergies. Conclusion This study demonstrated the application of a multiplex salivary immunoassay in Tribal Nations to provide insights regarding selected common pathogens which are transmitted through different transmission pathways including person-to-person contacts, contaminated food, soil and drinking water.https://doi.org/10.1007/s44197-024-00315-4Tribal NationsDrinking waterAntibody responseSalivaEpidemiology study |
| spellingShingle | Timothy J. Wade Jatin H. Mistry Swinburne A. J. Augustine Shannon M. Griffin Jason Kobylanski Jennifer Styles Elizabeth Sams Edward Hudgens Megan Kowalcyk Wesley Cochran Honorine Ward Andrey Egorov Salivary Antibody Responses to Potentially Waterborne and Environmentally Transmitted Infections Among Two Tribal Nations in the Southwest United States Journal of Epidemiology and Global Health Tribal Nations Drinking water Antibody response Saliva Epidemiology study |
| title | Salivary Antibody Responses to Potentially Waterborne and Environmentally Transmitted Infections Among Two Tribal Nations in the Southwest United States |
| title_full | Salivary Antibody Responses to Potentially Waterborne and Environmentally Transmitted Infections Among Two Tribal Nations in the Southwest United States |
| title_fullStr | Salivary Antibody Responses to Potentially Waterborne and Environmentally Transmitted Infections Among Two Tribal Nations in the Southwest United States |
| title_full_unstemmed | Salivary Antibody Responses to Potentially Waterborne and Environmentally Transmitted Infections Among Two Tribal Nations in the Southwest United States |
| title_short | Salivary Antibody Responses to Potentially Waterborne and Environmentally Transmitted Infections Among Two Tribal Nations in the Southwest United States |
| title_sort | salivary antibody responses to potentially waterborne and environmentally transmitted infections among two tribal nations in the southwest united states |
| topic | Tribal Nations Drinking water Antibody response Saliva Epidemiology study |
| url | https://doi.org/10.1007/s44197-024-00315-4 |
| work_keys_str_mv | AT timothyjwade salivaryantibodyresponsestopotentiallywaterborneandenvironmentallytransmittedinfectionsamongtwotribalnationsinthesouthwestunitedstates AT jatinhmistry salivaryantibodyresponsestopotentiallywaterborneandenvironmentallytransmittedinfectionsamongtwotribalnationsinthesouthwestunitedstates AT swinburneajaugustine salivaryantibodyresponsestopotentiallywaterborneandenvironmentallytransmittedinfectionsamongtwotribalnationsinthesouthwestunitedstates AT shannonmgriffin salivaryantibodyresponsestopotentiallywaterborneandenvironmentallytransmittedinfectionsamongtwotribalnationsinthesouthwestunitedstates AT jasonkobylanski salivaryantibodyresponsestopotentiallywaterborneandenvironmentallytransmittedinfectionsamongtwotribalnationsinthesouthwestunitedstates AT jenniferstyles salivaryantibodyresponsestopotentiallywaterborneandenvironmentallytransmittedinfectionsamongtwotribalnationsinthesouthwestunitedstates AT elizabethsams salivaryantibodyresponsestopotentiallywaterborneandenvironmentallytransmittedinfectionsamongtwotribalnationsinthesouthwestunitedstates AT edwardhudgens salivaryantibodyresponsestopotentiallywaterborneandenvironmentallytransmittedinfectionsamongtwotribalnationsinthesouthwestunitedstates AT megankowalcyk salivaryantibodyresponsestopotentiallywaterborneandenvironmentallytransmittedinfectionsamongtwotribalnationsinthesouthwestunitedstates AT wesleycochran salivaryantibodyresponsestopotentiallywaterborneandenvironmentallytransmittedinfectionsamongtwotribalnationsinthesouthwestunitedstates AT honorineward salivaryantibodyresponsestopotentiallywaterborneandenvironmentallytransmittedinfectionsamongtwotribalnationsinthesouthwestunitedstates AT andreyegorov salivaryantibodyresponsestopotentiallywaterborneandenvironmentallytransmittedinfectionsamongtwotribalnationsinthesouthwestunitedstates |