The PB2 I714S mutation influenced mammalian adaptation of the H3N2 canine influenza virus by interfering with nuclear import efficiency and RNP complex assembly

The PB2 I714S mutation influenced mammalian adaptation of the H3N2 canine influenza virus by interfering with nuclear import efficiency and RNP complex assembly

Avian influenza viruses (AIVs) are the origin of multiple mammal influenza viruses. The genetic determinants of AIVs adapted to humans have been widely elucidated, however, the molecular mechanism of cross-species transmission and adaptation of AIVs to canines are still poorly understood. In this st...

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Bibliographic Details
Main Authors: Xueyun Li, Tingting Jia, Kele Wang, Liangliang Wang, Lijuan Zhou, Mao Li, Wenfei Zhu, Yuelong Shu, Yongkun Chen
Format: Article
Language:English
Published: Taylor & Francis Group 2024-12-01
Series:Emerging Microbes and Infections
Subjects:
PB2
I714S mutation
H3N2 canine influenza virus
nuclear import efficiency
RNP complex assembly
Online Access:https://www.tandfonline.com/doi/10.1080/22221751.2024.2387439
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