MODERN TREATMENT OF DRUG-RESISTANT EPILEPSY, AVAILABLE IN RUSSIAN
Treatment of drug-resistant epilepsy is an extremely difficult task. Unfortunately, in Russia there are no regulations containing the algorithm of actions to help the practical neurologist in management of drug-resistant patients. It is obvious that there is an urgent need to establish a network of...
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| Format: | Article |
| Language: | Russian |
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IRBIS LLC
2016-06-01
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| Series: | Эпилепсия и пароксизмальные состояния |
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| Online Access: | https://www.epilepsia.su/jour/article/view/68 |
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| author | S. O. Ayvazyan Yu. S. Shiryaev |
| author_facet | S. O. Ayvazyan Yu. S. Shiryaev |
| author_sort | S. O. Ayvazyan |
| collection | DOAJ |
| description | Treatment of drug-resistant epilepsy is an extremely difficult task. Unfortunately, in Russia there are no regulations containing the algorithm of actions to help the practical neurologist in management of drug-resistant patients. It is obvious that there is an urgent need to establish a network of specialized epilepsy centers of level 4 (classification of the National Association of Epilepsy Centers, USA) in the territory of the Russian Federation, united by a common ideology and methodology.Objective: to increase the quality of care for patients with refractory forms of epilepsy, by combined use of non-drug treatments such as surgery, ketogenic diet and chronic vagus nerve stimulation (VNS Therapy).Material and methods. We observed 168 patients aged 1 to 18 years with refractory epilepsy.Results. Surgical treatment was performed in 63 patients, ketogenic diet — 73, VNS therapy — 32 patients. Analysis of the combined effectiveness showed the following results: complete seizure control was observed in 59 (35.1%) patients; reducing the number of seizures of more than 75% — in 19 (11.3%), 50% — and 53 (31.5%), no effect, — 37 (22%). Thus, the significant improvement was observed on the whole in 131 (78%) patients of 168. Conclusions. An integrated approach, involving a differentiated choice of a non-drug treatment allows to achieve significant positive results, despite the resistance of epilepsy to drug therapy. |
| format | Article |
| id | doaj-art-3e7c8a5e764e4324adf971f95f018012 |
| institution | DOAJ |
| issn | 2077-8333 2311-4088 |
| language | Russian |
| publishDate | 2016-06-01 |
| publisher | IRBIS LLC |
| record_format | Article |
| series | Эпилепсия и пароксизмальные состояния |
| spelling | doaj-art-3e7c8a5e764e4324adf971f95f0180122025-08-20T03:19:34ZrusIRBIS LLCЭпилепсия и пароксизмальные состояния2077-83332311-40882016-06-0181222810.17749/2077-8333.2016.8.1.022-02867MODERN TREATMENT OF DRUG-RESISTANT EPILEPSY, AVAILABLE IN RUSSIANS. O. Ayvazyan0Yu. S. Shiryaev1Scientific-Practical Center of Medical Care of Children, Moscow Health Department Medical Center «Nevromed», MoscowScientific-Practical Center of Medical Care of Children, Moscow Health DepartmentTreatment of drug-resistant epilepsy is an extremely difficult task. Unfortunately, in Russia there are no regulations containing the algorithm of actions to help the practical neurologist in management of drug-resistant patients. It is obvious that there is an urgent need to establish a network of specialized epilepsy centers of level 4 (classification of the National Association of Epilepsy Centers, USA) in the territory of the Russian Federation, united by a common ideology and methodology.Objective: to increase the quality of care for patients with refractory forms of epilepsy, by combined use of non-drug treatments such as surgery, ketogenic diet and chronic vagus nerve stimulation (VNS Therapy).Material and methods. We observed 168 patients aged 1 to 18 years with refractory epilepsy.Results. Surgical treatment was performed in 63 patients, ketogenic diet — 73, VNS therapy — 32 patients. Analysis of the combined effectiveness showed the following results: complete seizure control was observed in 59 (35.1%) patients; reducing the number of seizures of more than 75% — in 19 (11.3%), 50% — and 53 (31.5%), no effect, — 37 (22%). Thus, the significant improvement was observed on the whole in 131 (78%) patients of 168. Conclusions. An integrated approach, involving a differentiated choice of a non-drug treatment allows to achieve significant positive results, despite the resistance of epilepsy to drug therapy.https://www.epilepsia.su/jour/article/view/68drug-resistant epilepsy in childrenepilepsy surgeryketogenic dietvagus nerve stimulation |
| spellingShingle | S. O. Ayvazyan Yu. S. Shiryaev MODERN TREATMENT OF DRUG-RESISTANT EPILEPSY, AVAILABLE IN RUSSIAN Эпилепсия и пароксизмальные состояния drug-resistant epilepsy in children epilepsy surgery ketogenic diet vagus nerve stimulation |
| title | MODERN TREATMENT OF DRUG-RESISTANT EPILEPSY, AVAILABLE IN RUSSIAN |
| title_full | MODERN TREATMENT OF DRUG-RESISTANT EPILEPSY, AVAILABLE IN RUSSIAN |
| title_fullStr | MODERN TREATMENT OF DRUG-RESISTANT EPILEPSY, AVAILABLE IN RUSSIAN |
| title_full_unstemmed | MODERN TREATMENT OF DRUG-RESISTANT EPILEPSY, AVAILABLE IN RUSSIAN |
| title_short | MODERN TREATMENT OF DRUG-RESISTANT EPILEPSY, AVAILABLE IN RUSSIAN |
| title_sort | modern treatment of drug resistant epilepsy available in russian |
| topic | drug-resistant epilepsy in children epilepsy surgery ketogenic diet vagus nerve stimulation |
| url | https://www.epilepsia.su/jour/article/view/68 |
| work_keys_str_mv | AT soayvazyan moderntreatmentofdrugresistantepilepsyavailableinrussian AT yusshiryaev moderntreatmentofdrugresistantepilepsyavailableinrussian |