Unraveling pathogenesis and potential biomarkers for autism spectrum disorder associated with HIF1A pathway based on machine learning and experiment validation

Unraveling pathogenesis and potential biomarkers for autism spectrum disorder associated with HIF1A pathway based on machine learning and experiment validation

Background: Autism spectrum disorder (ASD) is a neurodevelopmental disorder with a high social burden and limited treatments. Hypoxic condition of the brain is considered an important pathological mechanism of ASD. HIF1A is a key participant in brain hypoxia, but its contribution to the pathophysiol...

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Bibliographic Details
Main Authors: Jinru Cui, Heli Li, Cong Hu, Feiyan Zhang, Yunjie Li, Ying Weng, Liping Yang, Yingying Li, Minglan Yao, Hao Li, Xiaoping Luo, Yan Hao
Format: Article
Language:English
Published: Elsevier 2025-01-01
Series:Neurobiology of Disease
Subjects:
Autism spectrum disorder
HIF1A
Machine learning
Microglia
Frontal cortex
IL-6
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996124003656
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